2 research outputs found
Role of proton pump inhibitors dosage and duration in Helicobacter pylori eradication treatment: Results from the European Registry on H. pylori management
Background: Management of Helicobacter pylori (H. pylori) infection requires co-treatment with proton pump inhibitors (PPIs) and the use of antibiotics to achieve successful eradication.Aim: To evaluate the role of dosage of PPIs and the duration of therapy in the effectiveness of H. pylori eradication treatments based on the 'European Registry on Helicobacter pylori management' (Hp-EuReg).Methods: Hp-EuReg is a multicentre, prospective, non-interventionist, international registry on the routine clinical practice of H. pylori management by European gastroenterologists. All infected adult patients were systematically registered from 2013 to 2022.Results: Overall, 36,579 patients from five countries with more than 1000 patients were analysed. Optimal (>= 90%) first-line-modified intention-to-treat effectiveness was achieved with the following treatments: (1) 14-day therapies with clarithromycin-amoxicillin-bismuth and metronidazole-tetracycline-bismuth, both independently of the PPI dose prescribed; (2) All 10-day (except 10-day standard triple therapy) and 14-day therapies with high-dose PPIs; and (3) 10-day quadruple therapies with clarithromycin-amoxicillin-bismuth, metronidazole-tetracycline-bismuth, and clarithromycin-amoxicillin-metronidazole (sequential), all with standard-dose PPIs. In first-line treatment, optimal effectiveness was obtained with high-dose PPIs in all 14-day treatments, in 10- and 14-day bismuth quadruple therapies and in 10-day sequential with standard-dose PPIs. Optimal second-line effectiveness was achieved with (1) metronidazole-tetracycline-bismuth quadruple therapy for 14- and 10 days with standard and high-dose PPIs, respectively; and (2) levofloxacin-amoxicillin triple therapy for 14 days with high-dose PPIs. None of the 7-day therapies in both treatment lines achieved optimal effectiveness.Conclusions: We recommend, in first-line treatment, the use of high-dose PPIs in 14-day triple therapy and in 10-or 14-day quadruple concomitant therapy in first-line treatment, while standard-dose PPIs would be sufficient in 10-day bismuth quadruple therapies. On the other hand, in second-line treatment, high-dose PPIs would be more beneficial in 14-day triple therapy with levofloxacin and amoxicillin or in 10-day bismuth quadruple therapy either as a three-in-one single capsule or in the traditional scheme
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Search for supersymmetry in hadronic final states with missing transverse energy using the variables αT and b-quark multiplicity in pp collisions at √s = 8 TeV
Submitted by Vitor Silverio Rodrigues ([email protected]) on 2014-05-27T11:30:34Z
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Previous issue date: 2013-09-01
An inclusive search for supersymmetric processes that produce final states with jets and missing transverse energy is performed in pp collisions at a centre-of-mass energy of 8 TeV. The data sample corresponds to an integrated luminosity of 11.7 fb-1 collected by the CMS experiment at the LHC. In this search, a dimensionless kinematic variable, αT, is used to discriminate between events with genuine and misreconstructed missing transverse energy. The search is based on an examination of the number of reconstructed jets per event, the scalar sum of transverse energies of these jets, and the number of these jets identified as originating from bottom quarks. No significant excess of events over the standard model expectation is found. Exclusion limits are set in the parameter space of simplified models, with a special emphasis on both compressed-spectrum scenarios and direct or gluino-induced production of third-generation squarks. For the case of gluino-mediated squark production, gluino masses up to 950-1125 GeV are excluded depending on the assumed model. For the direct pair-production of squarks, masses up to 450 GeV are excluded for a single light first- or second-generation squark, increasing to 600 GeV for bottom squarks. © 2013 CERN for the benefit of the CMS collaboration.
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Yerevan Physics Institute, Yerevan
Institut für Hochenergiephysik der OeAW, Wien
National Centre for Particle and High Energy Physics, Minsk
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Vrije Universiteit Brussel, Brussel
Université Libre de Bruxelles, Bruxelles
Ghent University, Ghent
Université Catholique de Louvain, Louvain-la-Neuve
Université de Mons, Mons
Centro Brasileiro de Pesquisas Fisicas, Rio de Janeiro
Universidade do Estado do Rio de Janeiro, Rio de Janeiro
Universidade Estadual Paulista, São Paulo
Universidade Federal do ABC, São Paulo
Institute for Nuclear Research and Nuclear Energy, Sofia
University of Sofia, Sofia
Institute of High Energy Physics, Beijing
State Key Laboratory of Nuclear Physics and Technology Peking University, Beijing
Universidad de Los Andes, Bogota
Technical University of Split, Split
University of Split, Split
Institute Rudjer Boskovic, Zagreb
University of Cyprus, Nicosia
Charles University, Prague
Academy of Scientific Research and Technology of the Arab Republic of Egypt Egyptian Network of High Energy Physics, Cairo
National Institute of Chemical Physics and Biophysics, Tallinn
Department of Physics University of Helsinki, Helsinki
Helsinki Institute of Physics, Helsinki
Lappeenranta University of Technology, Lappeenranta
DSM/IRFU CEA/Saclay, Gif-sur-Yvette
Laboratoire Leprince-Ringuet, Ecole Polytechnique IN2P3-CNRS, Palaiseau
Institut Pluridisciplinaire Hubert Curien, Universite de Strasbourg, Universite de Haute Alsace Mulh CNRS/IN2P3, Strasbourg
CNRS-IN2P3, Institut de Physique Nucléaire de Lyon Université de Lyon, Université Claude Bernard Lyon 1, Villeurbanne
Institute of High Energy Physics and Informatization Tbilisi State University, Tbilisi
I. Physikalisches Institut RWTH Aachen University, Aachen
III. Physikalisches Institut A RWTH Aachen University, Aachen
III. Physikalisches Institut B RWTH Aachen University, Aachen
Deutsches Elektronen-Synchrotron, Hamburg
University of Hamburg, Hamburg
Institut für Experimentelle Kernphysik, Karlsruhe
Institute of Nuclear and Particle Physics (INPP) NCSR Demokritos, Aghia Paraskevi
University of Athens, Athens
University of Ioánnina, Ioánnina
KFKI Research Institute for Particle and Nuclear Physics, Budapest
Institute of Nuclear Research ATOMKI, Debrecen
University of Debrecen, Debrecen
Panjab University, Chandigarh
University of Delhi, Delhi
Saha Institute of Nuclear Physics, Kolkata
Bhabha Atomic Research Centre, Mumbai
Tata Institute of Fundamental Research - EHEP, Mumbai
Tata Institute of Fundamental Research - HECR, Mumbai
Institute for Research in Fundamental Sciences (IPM), Tehran
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Politecnico di Bari, Bari
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Università del Piemonte Orientale (Novara), Torino
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Università di Trieste, Trieste
Kangwon National University, Chunchon
Kyungpook National University, Daegu
Institute for Universe and Elementary Particles Chonnam National University, Kwangju
Korea University, Seoul
University of Seoul, Seoul
Sungkyunkwan University, Suwon
Vilnius University, Vilnius
Centro de Investigacion y de Estudios Avanzados del IPN, Mexico City
Universidad Iberoamericana, Mexico City
Benemerita Universidad Autonoma de Puebla, Puebla
Universidad Autónoma de San Luis Potosí, San Luis Potosí
University of Auckland, Auckland
University of Canterbury, Christchurch
National Centre for Physics Quaid-I-Azam University, Islamabad
National Centre for Nuclear Research, Swierk
Institute of Experimental Physics, Faculty of Physics University of Warsaw, Warsaw
Laboratório de Instrumentação e Física Experimental de Partículas, Lisboa
Joint Institute for Nuclear Research, Dubna
Petersburg Nuclear Physics Institute, Gatchina (St. Petersburg)
Institute for Nuclear Research, Moscow
Institute for Theoretical and Experimental Physics, Moscow
P.N. Lebedev Physical Institute, Moscow
Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State University, Moscow
State Research Center of Russian Federation Institute for High Energy Physics, Protvino
Faculty of Physics and Vinca Institute of Nuclear Sciences University of Belgrade, Belgrade
Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Madrid
Universidad Autónoma de Madrid, Madrid
Universidad de Oviedo, Oviedo
Instituto de Física de Cantabria (IFCA) CSIC-Universidad de Cantabria, Santander
European Organization for Nuclear Research CERN, Geneva
Paul Scherrer Institut, Villigen
Institute for Particle Physics ETH Zurich, Zurich
Universität Zürich, Zurich
National Central University, Chung-Li
National Taiwan University (NTU), Taipei
Chulalongkorn University, Bangkok
Cukurova University, Adana
Physics Department Middle East Technical University, Ankara
Bogazici University, Istanbul
Istanbul Technical University, Istanbul
National Scientific Center Kharkov Institute of Physics and Technology, Kharkov
University of Bristol, Bristol
Rutherford Appleton Laboratory, Didcot
Imperial College, London
Brunel University, Uxbridge
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Brown University, Providence
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California Institute of Technology, Pasadena
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Fermi National Accelerator Laboratory, Batavia
University of Florida, Gainesville
Florida International University, Miami
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