27 research outputs found
5-Azacytidine Acts Directly on Both Erythroid Precursors and Progenitors to Increase Production of Fetal Hemoglobin
Get PDFAbstract The effect of 5-azacytidine on erythroid precursors and progenitors was studied in nine patients with sickle cell anemia or severe thalassemia. Each patient received the drug intravenously for 5 or 7 d. 5-Azacytidine caused a four-to sixfold increase in y-messenger RNA concentration in bone marrow cells of eight of the nine patients and decreased the methylation frequency of a specific cytosine residue in th
Laboratory Evaluation of Differential White Blood Cell Count Information from the Coulter S-Plus IV® and Technicon H-1® in Patient Populations Requiring Rapid “Turnaround” Time
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