Impact of Customer Self Concept and Life Style on Luxury Goods Purchases: A Case of Females of Karachi

Luxuries are now being necessities for people day by day because people wants to be improve their life styles and by the utilization of luxury products they can fulfilled their self -concept by having a better social appreciation from society . The core reason of this research paper was to  examined Impact of customer self concept and life style on luxury goods purchases a case of females of Karachi. In today's competitive world companies tried  their best to make customer satisfied as customer satisfaction is very important because customer is the back bone of the organization. Companies knows that customer want quality, authenticity and a needs the history of a brand. The luxury brands are completely different offers and needed a very detailed approach to marketing and brand management. Quantitative research is used in this research paper and we have targeted females of Karachi  who aged between 25-30 years. 200 is sample size of this research paper. The answers of the individuals were geted both electronically and manually. Frequency tables and pie charts were used to checked the result with the help of SPSS. On the basis of result it has been accomplished that there is a positive significant  impact of self -concept and life style of customer on  purchases of luxury goods Keywords: Luxury goods, Self concept, Life styl

Impact of Body Weight on Self-Esteem among Undergraduate Young Adult Students of Doctor of Physiotherapy, Karachi

Objectives: To determine the recurrence of body disappointment, loss of control and self- related wellbeing in interpose the relationship among body weight and impairments in self-esteem among students of Doctor of Physiotherapy (DPT) Material and Methods: The research was among youthful understudies of the two sexes (boys and girls) of Doctor of Physiotherapy in both campuses—removed for blind review---. Concluded an overview through the questionnaire (Rosenberg Self-Esteem Scale according to the sample size of 298 computed through online programming Open Epi. The survey was acknowledged globally and it was standardized questionnaire. The data was assembled by figuring the BMI among body weight understudies of (DPT) and to check the level of self-esteem by Rosenberg Self-Esteem Scale. The survey conducted from January 2019 to February 2019. Results: Normal weight was adjusted to 18.50 till 24.90 – a total of 81 respondents, Overweight was adjusted to 25.00 till 29.90 of 35 respondents, obese category was adjusted to 30.00 or more a total of 17 respondents were adjudged to be in this category as per weigh ranges BMI. After analyzing the Chi-Square tabulation, it was found that the highest self-esteem was found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. As the table shows that girls have more self-esteem as compared to the boys, although the girl’s respondents are more so than boys are. Conclusion: It has been conclude that the proportion of the highest self-esteem were found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. Keywords: Body Mass Index, Stress, Obesity, Body image, Depression and Self-esteem

Impact of Body Weight on Self-Esteem among Undergraduate Young Adult Students of Doctor of Physiotherapy, Karachi

Objectives: To determine the recurrence of body disappointment, loss of control and self- related wellbeing in interpose the relationship among body weight and impairments in self-esteem among students of Doctor of Physiotherapy (DPT) Material and Methods: The research was among youthful understudies of the two sexes (boys and girls) of Doctor of Physiotherapy in both campuses—removed for blind review---. Concluded an overview through the questionnaire (Rosenberg Self-Esteem Scale according to the sample size of 298 computed through online programming Open Epi. The survey was acknowledged globally and it was standardized questionnaire. The data was assembled by figuring the BMI among body weight understudies of (DPT) and to check the level of self-esteem by Rosenberg Self-Esteem Scale. The survey conducted from January 2019 to February 2019. Results: Normal weight was adjusted to 18.50 till 24.90 – a total of 81 respondents, Overweight was adjusted to 25.00 till 29.90 of 35 respondents, obese category was adjusted to 30.00 or more a total of 17 respondents were adjudged to be in this category as per weigh ranges BMI. After analyzing the Chi-Square tabulation, it was found that the highest self-esteem was found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. As the table shows that girls have more self-esteem as compared to the boys, although the girl’s respondents are more so than boys are. Conclusion: It has been conclude that the proportion of the highest self-esteem were found in the normal weight BMI category respondents followed by the overweight category and the lowest self-esteem was found in obese category. Keywords: Body Mass Index, Stress, Obesity, Body image, Depression and Self-esteem

Prevalence and Associated factors Of Temporomandibular Joint Dysfunction among Young Adults in Karachi

ABSTRACT Objective: The objective of the study was to determine the prevalence and associated factors for temporomandibular joint dysfunction among young adult in Karachi. Material and Methods: A cross-sectional study was carried out in (n=383) subjects with (n=165) males and (n=218) females aged between 18–30 years. The subjects were requested to answer Fonseca’s questionnaires, consisted on ten questions. The collected data sets were analyzed statistically through using the SPSS version 22. Result: A total (n=383) participants, the prevalence of TMD is 66.6%. The participant with TMD (66.6%) show 54.0% mild TMD, 12.0% moderate and 0.5% severe. Women with 61% showing TMD, as compare to men 73.93%. When considering only severe TMD, only women are affected 0.5%. Participant with any level of TMD show marked characteristics: 12.53% considered themselves tense people; 17.5% reported to clench or grind their teeth; 8.88% reported clicking of the temporomandibular joint; 24.28% reported frequent headache. Conclusion: The result of the study concluded that the TMD a high prevalence among young adult in Karachi, among participant with TMD most of the participants had mild TMD which reveals that in young population about half of the participants presented with mild TMD. Key Points: Temporomandibular disorders (TMDs), Mastication, Helkimo's indexes, Fonseca anamnestic Index (FAI

X-linked agammaglobulinemia - first case with bruton tyrosine kinase mutation from Pakistan

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency with more than 600 mutations in Bruton tyrosine kinase (Bkt) gene which are responsible for early-onset agammaglobulinemia and repeated infections. Herein we present a case of a 3-year-old boy with history of repeated diarrhoea and an episode of meningoencephalitis with hemiplegia. The workup showed extremely low levels of immunoglobulin with low CD+19 cells. Genetic analysis showed Btk mutation 18 c.1883delCp.T628fs. To the best of our knowledge this is the first report of a case of XLA confirmed by molecular technique from Pakistan

The spectrum of primary immunodeficiencies at a tertiary care hospital in Pakistan

Background: Primary Immunodeficiency Disorders (PIDs) are well-known disorders in the West. but the recognition and diagnosis of these disorders is challenging in developing countries. We present the spectrum of PIDs seen at a tertiary care center in Pakistan, identified using clinical case definitions and molecular methods.Methods: A retrospective chart review of children suspected to have PID was conducted at the Aga Khan University Hospital (AKUH) Karachi, Pakistan from 2010 to 2016. Data on demographics, clinical features, family history of consanguinity, sibling death, details of laboratory workup done for PID and molecular tests targeted panel next generation sequencing (NGS) or whole exome sequencing (WES) performed at the Geha laboratory at Boston Children\u27s Hospital, USA was collected. The study was exempted from the Ethical Review Committee of AKUH.Results: A total of 43 children visited the hospital with suspected PID during the study period. Genetic testing was performed in 31/43 (72.1%) children. A confirmed diagnosis of PID was established in 20/43 (46.5%) children. A pathogenic gene variant was identified in 17(85%) of the 20 confirmed cases (Table 1). Twelve (60%) of the confirmed cases of PID were male. The most common presenting symptom was recurrent diarrhea 11/20 (55%). The mean (±S.D) age of the cases at the time of diagnosis was 4.2 (±4.1) years. Chronic granulomatous disease (CGD) was the most common 6/20 (30%) disorder, followed by severe combined immunodeficiency (SCID) 3/20 (15%), leukocyte adhesion deficiency (LAD) 3/20 (15%), agammaglobulinemia/hypogammaglobulinemia 3/20 (15%), and Hermansky-Pudlak Syndrome (HPS) 2/20 (10%). Wiskott-Aldrich Syndrome, Immunodeficiency Centromeric Instability and Facial Anomalies Syndrome (ICF 2), Trichohepatoenteric syndrome (TRES), and C3 deficiency were each diagnosed once {1/20 (4.3%) each} (Table 1). Of these 20 confirmed cases, almost all 19/20 (95%) had a family history of consanguinity. Sibling death was reported in 5/20 (25%) of these cases. Five out of the 20 (25%) children died over the 7-year period for various reasons.Conclusion: PIDs are not uncommon in Pakistan; their diagnosis may be missed or delayed due to the overlapping of clinical features of PID with other diseases and a lack of diagnostic facilities. There is a need to build capacity for early recognition and diagnosis of PIDs to decrease morbidity and mortality

The safety and efficacy of Houtou Jianweiling tablet in patients with chronic non-atrophic gastritis: a double-blind, non-inferiority, randomized controlled trial

Background: Common symptoms of Chronic Non-atrophic Gastritis (CNAG) include nausea, stomach distension, and abdominal pain. The Houtou Jianweiling Tablet (HTJWT) is a chinese patent medicine (CN1368229A) and it has been used clinically for more than 20 years with proven clinical efficacy in treating CNAG, prompted us to establish the clinical efficacy and safety of HTJWT on patients with mild to moderate CNAG symptoms in Pakistani population.Methods: This phase II, double-blind, randomized, parallel-controlled trial was conducted in a single center between November 2022 and February 2023 in Pakistan. In a ratio of 1:1, total 240 CNAG patients with erosion identified by pathological biopsy and gastroscopy were randomly assigned to control (Omeprazole) group (n = 120) and the treatment (HTJWT) group (n = 120). Patients in the treatment group received orally four HTJWT (0.38g/tablet), three times a day and one placebo of Omeprazole enteric-coated tablet prior to breakfast, daily. On the other hand, patients in the control group received one Omeprazole enteric-coated tablet (20 mg/tablet) prior to breakfast and four placebo of HTJWT, thrice a day. The patients consumed the investigated drugs (i.e., treatment and control) treatment regimen was followed for a duration of 28 days. The safety of the patients were evaluated through adverse events, serious adverse events and laboratory tests such as blood biochemistry, urine analysis, liver and renal function tests. Vital signs like; blood pressure, pulse rate, body temperature, respiratory rate for all the patients were recorded. The cardiac status of the patients were assessed through electrocardiogram (ECG). The primary efficacy indicators were the improvement rate of gastric distention and gastralgia as the main clinical symptoms. Secondary indicators were visual analogue score (VAS); improvement rate of secondary clinical symptoms and signs; improvement rate of total clinical signs and symptoms; the disappearance/remission rate of Gastric pain and, remission/disappearance time of gastric distension; and the negative conversion rate of Helicobacter pylori (H. pylori). The outcomes among each group were compared using the chi-square test.Results: Patients in both groups had good drug compliance (80%–120%), and there was no statistically significant difference in the patients’ baseline characteristics. The clinical improvement rate was found to be 91.1% in the treatment group and 91.0% in the control group with negligible variation among the two groups (p = 0.9824; 95% confidence interval: -0.0781–0.0798). Similarly, hardly no difference was found in the negative conversion rate of H. pylori between the treatment group and the control group (i.e., 70.1% and 71.8% respectively, p = 0.8125). There were no significant differences in respiratory rate, vital signs, blood pressure, laboratory results for blood biochemistry, urine analysis, liver and renal function tests between the two groups. The ECG assessment carried out for the treatment and control group revealed no considerable difference. Margin variation in the disappearance time of gastric pain (p = 0.1860) and remission rate (p = 0.5784) between the two groups were observed. The control group exhibited a faster remission period for gastrointestinal discomfort indications as compared to treatment group (p = 0.0430). Only one patient in the control group experienced mild to moderate adverse events, namely,; epigastric pain and dyspepsia. The results were consistent with the intention-to-treat and per-protocol analysis that included patients who were 100% compliant to the assigned therapy.Conclusion: The lower limit of confidence interval (CI, 95%) for the differences in the effective rate between the treatment and the control groups was found to be −0.0781 which is greater than −0.15, hence the treatment group is non-inferior to the control group. The therapeutic dosage used in the trial and treatment period did not cause any significant adverse event, and there were no obvious changes in the ECG profile, vital signs and biochemistry of the patients. Based on the clinical efficacy evaluation and reported adverse events, it can be concluded that the HTJWT is a safe and effective traditional chinese medicine for the treatment of patients suffering from chronic non-atrophic gastritis with mild to moderate symptoms.Clinical Trial Registration: [www.clinicaltrials.gov], identifier [NCT04672018]

A randomized, double-blind, positive-controlled, Phase-II clinical trial to evaluate efficacy and safety of Fuke Qianjin capsule in Pakistani patients with pelvic inflammatory disease

Ethnopharmacological relevance: Pelvic inflammatory disease (PID) is a frequently occurring gynecological disorder mainly caused by the inflammation of a woman’s upper genital tract. Generally, antibiotics are used for treating PID, but prolonged use poses potential risks of gut bacterial imbalance, bacterial resistance, super bacteria production, and associated adverse reactions. Traditional Chinese medicine (TCM) has shown unique advantages in various ailments and has received widespread clinical research attention. Fuke Qianjin (FUKE) capsule is an approved National Medical Products Administration (NMPA License No. Z20020024) Chinese herbal prescription that has been widely used individually or in combination with other Western medicines for the treatment of various gynecological inflammatory diseases, including chronic cervicitis, endometritis, and chronic PID.Aim: This clinical trial was designed to assess the safety and efficacy of FUKE capsule in mild-to-moderate symptomatic PID patients.Materials and methods: This phase 2, randomized, double-blind, positive controlled clinical trial was conducted in mild-to-moderate symptomatic PID patients at a single center in Pakistan from 21 September 2021 to 11 March 2022. Eligible female participants were randomly assigned to a test and a control group with a ratio of 1:1. The test group subjects received two metronidazole (METRO) tablets and one doxycycline hyclate (DOXY) simulant at a time, twice daily for 14 days, and two Fuke Qianjin (FUKE) capsules, three times a day after a meal for 28 days. Subjects in the control group received two METRO tablets and one DOXY tablet at a time, twice daily for 14 days, and two FUKE simulant capsules, three times a day after meal for 28 days. The primary efficacy outcome was an improvement in pelvic pain symptoms assessed through a visual analog scale (VAS). The secondary outcomes were the improvement in secondary efficacy symptoms like local physical signs, clinical assessment of leucorrhea and cervical secretions through laboratory examination, and improvement in the maximum area of pelvic effusion assessed through gynecological ultrasound after the treatment. The safety outcomes were assessed through vital signs, laboratory tests, electrocardiogram findings, and adverse events/serious adverse events.Results: A total of 198 subjects with active PID were randomly assigned to a test group (n = 99) and a control group (n = 99). The baseline characteristics of the subjects in the two groups were similar. In the intention-to-treat analysis, the primary efficacy was 84.9% for the test group and 71.6% for the control group, with a statistically significant difference (p = 0.0370; 95% CI −0.2568 to −0.0088). The secondary clinical efficacy was 88.4% for the test group and 82.7% for the control group, with no significant difference (p = 0.2977; 95% CI −0.1632 to 0.0501). The improvement in local physical signs was 95.8% for the test group and 76.9% for the control group, with no significant difference (p = 0.0542; 95% CI −0.3697 to −0.0085). The inter-group non-inferiority comparison showed that the upper limit of the 95% CI was less than 0.15 and thus met the non-inferiority requirements of the test group to the control group. The results of clinical signs of leucorrhea and cervical secretions showed that there was no difference in the rate of improvement between the test and control groups, indicating that FUKE was non-inferior to DOXY. A total of 14 adverse events in eight subjects were observed in the trial, with an incidence rate of 4.7%. Four subjects in each group experienced seven adverse events with 4.5% and 4.8% incidence rates of adverse reactions in the test and control groups, with no statistically significant differences (p = 0.2001). No serious adverse events occurred in the trial.Conclusion: The results of this trial indicate that the test drug (Fuke Qianjin capsule) is non-inferior to the control drug (doxycycline hyclate tablet) in treating mild-to-moderate PID patients with comparable efficacy, safety, and tolerability to the control drug.Clinical Trial Registration:www.clinicaltrials.gov, identifier NCT04723069