Phytochemicals and Antioxidant Activity Investigation of Butea monosperma Lam. Leaves Ethanol Extract

The aim of this study was to investigate phytochemicals and antioxidant activity of plant Butea monosperma Lam. leaves ethanol extract. The different extracts of this plant were reported the rich source contents of bioactive phytochemicals in the leaves and afford for various pharmacological activities. The ethanol extract of leaves was subjected to investigate phytochemicals and antioxidant activity by using DPPH in vitro system. The provided evidence of results concluded that the ethanol extract of Butea monosperma Lam. leaves are potential sources of natural bioactive phytochemicals and showed potent in vitro antioxidant activity with their IC50 value of 44.16 μg/ml. Therefore phytochemical investigation of plant leaves ethanol extract was noted various bioactive phytochemicals, which may serve as a potent source of natural antioxidants

ANALYSIS OF BIOLOGICAL ACTIVITY AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY STUDY OF CONVENTIONAL EXTRACTION OF VITEX NEGUNDO LINN. LEAVES

Objective: The main objective of the present work is to carry out the biological activity, gas chromatography-mass spectrometry (GC-MS) studies for the possible compounds present in Vitex negundo.Methods: The aqueous extract of V. negundo Linn. was screened for biological activities such as antimicrobial, antituberculosis (TB), antimalarial, and antioxidant activities. The GC-MS analysis was carried out.Results: The result shows that leaf extract is effective against Escherichia Coli and Bacillus subtitus while negative results for anti-TB and anti-malarial activity. The antioxidant activity of the leave extract is excellent.Conclusion: The compounds present in the leaf extract of V. negundo are responsible for possessing the biological activity

Biosynthesis Of Silver Nanoparticle Using Aqueous Extract Of Hibiscus Rosasinensis Leaves

The present study is for the green formation of silver nanoparticles by Hibiscus rosasinensis  leaves extract. After successful formation of silver nanoparticles, Confirmation of Ag nanoparticles has carried out by using various characterizations techniques viz. structural by FT-IR, X-Ray Diffraction (XRD), morphological by Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and elemental by Energy Dispersive X-ray Spectroscopy (EDX). The silver nanoparticles are also characterized for antibacterial activity. Staphylococi aures, Strepotococci pyogens, Salmonella typhy

PHYTOCHEMICAL AND PHYSICOCHEMICAL ANALYSIS OF MICROWAVE-ASSISTED EXTRACTION CORIANDRUM SATIVUM L. LEAVES AND ITS BIOLOGICAL EVALUATION

Objective: The main objective of the present work is to carry out the phytochemical constituent present and physicochemical analysis of microwave-assisted extract (MAE) of Coriandrum sativum leaves and to investigate its antibacterial activity. Methods: The powdered samples of the leaves were extracted and analyzed for physicochemical properties. Extraction was carried out for C. sativum using different solvents and used for phytochemical investigation. Infrared (IR) spectrum and antibacterial activity of MAE were carried out. Results: The results show that the percentage extract is different in the different solvents and also differs in phytochemical constituents. Phytochemicals present in the MAE also confirmed by IR spectroscopy. MAE is active against bacteria. Conclusion: The phytochemicals present in C. sativum is confirmed by IR spectrum and these phytochemicals responsible for antibacterial activity

Design, Synthesis, Cytotoxicity and Molecular docking studies of 1-(4-methoxyphenyl)-N-substituted phenyl-1H-1,2,3-triazole-4-carboxamide derivatives

Abstract A new series of 1-(4-methoxyphenyl)-N-substituted phenyl-1H-1,2,3-triazole-4-carboxamide derivates (4A-4N) have been synthesized in excellent yields and structures were characterized by spectral techniques like 1H-NMR, 13C-NMR, LC-MS &amp; FT-IR. The newly synthesized derivatives were evaluated for anticancer activity against breast cancer cell lines MCF-7 and MDA-MB-231. Among them, compound 4H (IC50 = 13.11 µM and 23.61 µM) and compound 4M (IC50 = 11.55µM to 31.87µM) shows good cytotoxicity activity toward both cell line, while compounds 4B (IC50 = 9.48 µM), 4I (IC50 = 7.11 µM), and 4J (IC50 = 8.27 µM) showed promising cytotoxicity against MCF-7 cell line as compared with standard (Doxorubicin). Also explored docking study with binding mode of interactions and active site in EGFR tyrosinse (PDB ID: 2J5F) proteins and molecular docking study shows very good interaction with the tyrosinse kinase active site. In addition of this targeted compounds were studied the pharmacokinetic and the compounds were follow Lipinski’s rule of five as well as compounds have acceptable good drug-likeness score properties.</jats:p