CODATA and global challenges in data-driven science

This synthesis report presents the scientific results of the international conference "Global Challenges and Data-Driven Science" which took place in St. Petersburg, Russian Federation from 8 October to 13 October 2017. This event facilitated multidisciplinary scientific dialogue between leading scientists, data managers and experts, as well as Big Data researchers of various fields of knowledge. The St. Petersburg conference covered a wide range of topics related to data science. It featured discussions covering the collection and processing of large amounts of data, the implementation of system analysis methods into data science, machine learning, data mining, pattern recognition, decision-making robotics and algorithms of artificial intelligence. The conference was an outstanding event in the field of scientific diplomacy and brought together more than 150 participants from 35 countries. It's success ensured the effective data science dialog between nations and continents and established a new platform for future collaboration

Dry skin syndrom (DSS)

The aim of the study - to consider the clinical aspects of dry skin, as well as methods for moisturizing and rehabilitating the skin in accordance with the international methodological standard of dermatovenereology and cosmetology.Цель исследования - рассмотреть клинические аспекты сухости кожи, а также методы ее увлажнения и реабилитации кожных покровов в соответствии с международным методологическим стандартом дерматовенерологии и косметологии

Comparison of adherent and non-adherent cell phenotypes of breast carcinoma cultures. Ural medical journal

The aim of the study was to determine the effect of the method of culturing BC cells on the ability of cells to preserve the epithelial phenotype.Цель исследования – определить влияние методики культивирования клеток КМЖ на способность клеток сохранять эпителиальный фенотип

Fixed-dose combinations in the treatment of hypertension to increase adherence

Despite a wide range of antihypertensive drugs, blood pressure (BP) control often remains unsatisfactory, and every year the number of people with uncontrolled high BP increases. One of the strategies aimed at improving medical adherence is the use of fixed-dose combinations of 2 antihypertensive drugs for starting therapy, and, if necessary, 3 drugs. Initiation of therapy with 2 drugs in one tablet is recommended for most patients. A review of algorithms for choosing combinations of antihypertensive drugs in different clinical situations, including in patients with various comorbid conditions, is presented. Simplification of treatment regimens makes it possible to choose the most optimal solutions in various clinical situations, in particular, with stage I-II hypertension, with a combination of hypertension with chronic kidney disease, as well as with a combination of hypertension with coronary artery disease and a number of other diseases

Myofascial pain syndrome: risk factors, diagnosis and local therapy

One of the main reasons for seeking medical help is myofascial syndrome (MFS), which is manifested by local inflammation with elements of degenerative changes in the affected tissue, pain and muscle spasm due to dysfunctional disorders in the nociceptive system and a decrease in the quality of life. This review discusses etiopathogenesis in detail, taking into account the factors predisposing to the development of MFS, which are divided into anatomical, ergonomic, medical and psychosocial, and also provides diagnostic criteria for pain MFS, including 5 large and 3 small criteria necessary for diagnosis. The second part of the review examines the indications, efficacy, safety, and benefits of topical forms of nonsteroidal anti-inflammatory drugs (NSAIDs), which have a moderate effect on pain, but have a much better safety profile due to reduced systemic absorption. The use of topical drugs allows you to create an effective concentration of the drug directly in the lesion and avoid undesirable systemic effects. Experts strongly recommend prescribing primarily topical, rather than oral, NSAIDs to patients aged 65 years and older who have concomitant cardiovascular and renal pathology, as well as diseases of the gastrointestinal tract. In more detail, the review examines topical forms of diclofenac, which differ in the maximum degree of transdermal penetration compared to other NSAIDs and the effect of slow release of the active substance into the surrounding tissues

ANALYSIS OF CHEESES MADE BY WASTE-FREE TECHNOLOGY

The growing scarcity of resources and insufficient consumption of protein products by the majority of the world's population contributes to the rational use of all resources. Secondary milk raw materials are a source of protein and require mandatory processing. The study was aimed at developing a rational waste-free technology for processing raw milk into cheeses with high nutritional value and low cost. For research, three samples of cheeses were made: sample 1 - based on milk; sample 2 - based on cheese whey (0.3% citric acid solution was used for coagulation); sample 3 (caramel) - from a mixture of milk and whey (without curdling). Standard methods were used to determine organoleptic, physicochemical parameters. The nutritional value of the products was calculated according to the physicochemical parameters established during the study (mass fraction of proteins, fats, and carbohydrates). The proposed waste-free technology can be implemented in any cheese factory for the production of soft and hard cheeses. Products derived from whey are somewhat inferior in amino acid composition but have a relatively high value and organoleptic properties inherent in cheeses made from milk. The use of a citric acid solution for curdling makes it possible to reduce the duration of the process by 30 minutes and increase the yield of cheese by 5–7%. An evaluation of the organoleptic characteristics of the property showed that the cheese made from milk and whey does not differ. Cheese made from milk contains the largest mass fraction of proteins (17.2 g / 100g) and fats (20 g / 100g), the largest amount of carbohydrates is cheese based on a mixture of whey and milk (49 g / 100g). Cheese is made from whey and has the lowest energy value (88.14 kcal). At the same time, the mass fraction of proteins in this cheese is higher than in cheese made from a mixture of whey and milk (sample 3). The results of the study of the amino acid composition showed that all cheeses have the same qualitative amino acid composition. According to the quantitative composition of amino acids, cheeses made from milk have the highest biological value

Association of high-sensitivity C-reactive protein with fatal and non-fatal cardiovascular events in working-age people: data from the ESSE-RF study

Aim. To study the relationship of different levels of high-sensitivity C-reactive protein (hs-CRP) with cardiovascular events and assess its contribution to the development of outcomes in Russian regions.Material and methods. The work used the data from the multicenter study ESSE-RF — a representative sample of male and female population aged 25-64 years. All participants signed informed consent. The study included 10421 people (women, 6399 (61,4%)). The cohort was followed up from 2012 to 2019 (median follow-up period, 5,5 years). A hard endpoint (cardiovascular mortality and nonfatal myocardial infarction (MI)) was determined in 187 people, while a soft endpoint (nonfatal MI, stroke, revascularization, heart failure progression and cardiovascular mortality) — in 319 people.Results. The results showed that hs-CRP is significantly associated with the main risk factors (with the exception of low-density lipoproteins). At the same time, it was found that optimal hs-CRP level for predicting the risk of cardiovascular events (CVE) in Russian population is significantly lower than 3 mg/L, but higher than 1 mg/L (1,54/1,89 mg/dL for men and women, respectively). Adding hs-CRP to sex and age significantly improved risk prediction (AUC, 79,7; 95% CI, 77,8-81,7). At the same time, adding a wide list of confounders to hs-CRP, sex and age does not improve the model’s predictive value (AUC, 79,7; 78,2-82,1).Conclusion. This study for the first time showed a significant independent contribution of hs-CRP to CVEs development in the Russian population, and the addition of hs-CRP to sex and age significantly increased the predictive value of model