Formulasi Dan Karakteristik Fisik Sediaan Plester Hidrogel Ekstrak Daun Ciplukan (Physalis angulata L.) Dan Batang Kayu Manis (Cinnamomum burmannii)

Diabetes mellitus is a degenerative disease caused by the damage of beta pancreatic cells. This caused many complication such as diabetic ulcer which left untreated can cause an open wound hard to heal thereby reducing the quality of life. Treatment of diabetic ulcer despite using antidiabetic also using an antibiotic therapy like Mupirocin. In its development, the use of natural ingredients is known to be used as adjuvant therapy for diabetic ulcer such as Ciplukan leaves and Kayu Manis bark. Both of the plant contain phytochemical compound like sinamaldehid, tannin, polyphenol and flavonoid which can work as wound healer. To increase its efficacy then Ciplukan leaves and Kayu Manis bark were formulated as hydrogel patch. Hydrogel patch are known has advantages like better penetration, hygienic and easy to administered Ciplukan (Physalis angulata L.) leaves and Kayu Manis (Cinnamomum burmannii) Bark extracted with maceration technique. The extracts then made into matrix type hydrogel patch with 10% HPMC and 5% PVA as backing patch. The backing patch and extract then placed on a square cast and dried under room temperature for 24 hours. The hydrogel patch then evaluated for physical characteristic including organoleptic aspect, weight uniformity, moisture content and pH. The results showed that Ciplukan leaves and Kayu Manis Bark hydrogel patch have a semi solid consistency, transparent greenish color and distinctive smell. The average pH is 5,5 and have average weight around 1,18 grams. The moisture contens of hydrogel patch is 2,42%. The Ciplukan leaves and Kayu Manis bark is able to formulated into hydrogel patch. The hydrogel patch is showing good appearance and having good properties as topical dosage form. The pH of the hydrogel patch is suitable with pH of the skin and have no intention to irritate the skin. Hydrogel patch also giving a cooling sensations in wound area thus increase patients convenience and acceptability.  Keywords: Diabetes mellitus, extract, drug delivery system, hydrogel patch, adjuvant therap

Lactuca sativa Sebagai Terapi Alternatif Terapi Pada Pasien Dengan Gangguan Tidur

Tidur merupakan salah satu masalah kesehatan yang sangat penting. Untuk melakukan aktivitas normal, seorang manusia membutuhkan kualitas dan jumlah tidur yang cukup. Selain itu, tidur juga memiliki peran yang sangat kompleks dalam membantu penyembuhan tubuh baik secara fisik maupun secara emosional. Pengobatan pada penderita gangguan tidur selama ini dilakukan dengan menggunakan agen farmakologis seperti benzodiazepin. Namun, penggunaan obat ini secara jangka panjang dapat menyebabkan efek samping, metode nonfarmakologis menggunakan bahan alami dari tanaman pada saat ini telah banyak diamati dan disarankan sebagai salah satu pendekatan alternatif tetapi dengan efek samping yang lebih ringan dibandingkan obat konvensional. Pada penelitian ini dibahas mengenai potensi Lactuca sativa sebagai obat alternatif pada pasien dengan gangguan tidu

Review Artikel : Desain dan Karakteristik Self Nano Emulsifying Drug Delivery System (SNEDDS)

Objective: Sistem Nanoemulsi Penghantaran Obat (Self-Nanoemulsifying Drug Delivery System/SNEDDS) merupakan salah satu pendekatan inovatif dalam penghantaran obat yang bertujuan meningkatkan kelarutan dan bioavailabilitas obat-obatan yang sulit larut dalam air. Bioavalabilitas merupakan kunci penting dalam penyerapan obat dari saluran pencernaan sehingga peningkatan bioavailabilitas dapat memperbaiki profil kinetika obat dalam tubuh. Review terhadap SNEDDS pada artikel ini bertujuan untuk mengulas mengenai keunggulan SNEDDS, desain formulasi dan memahami karakteristik SNEDDS yang baik sebagai sebuah bentuk sistem pengahantaran obat. Methods: jenis metode penelitian yang digunakan pada artikel ini adalah literature review dengan cara mengumpulkan artikel dalam bentuk jurnal mengenai topik desain formulasi dan karakteristik SNEDDS. Results: SNEDDS dibuat dengan menggabungkan berbagai minyak, surfaktan, dan co-surfaktan. Keberhasilan formulasi dari SNEDDS membutuhkan ketelitian yang besar dalam pemilihan komposisi formulasi. Studi preformulasi seperti solubilitas, efisiensi emulsifikasi harus dilakukan untuk menentukan pilihan yang tepat dalam formulasi SNEDDS. Conclusion: Dalam rentang tahun 2005-2020, penelitian dan pengembangan SNEDDS telah menunjukkan potensinya dalam meningkatkan kelarutan dan bioavailabilitas obat-obat yang sulit larut dalam air. Meskipun masih ada tantangan yang perlu diatasi, SNEDDS memiliki potensi yang besar dalam meningkatkan efisiensi terapi obat

ANALISIS PERSENTASE AGGREGASI PLATELET PADA PASIEN DENGAN PENYAKIT JANTUNG KORONER DENGAN PEMBERIAN KOMBINASI ANTIPLATELET TICAGRELOR-ASPIRIN (Penelitian Dilakukan DI PPJT RSUD Dr Soetomo Surabaya)

In this study, the percentage analysis of platelet aggregation was carried out in patients with a diagnosis of coronary heart disease who received a combination of ticagrelor-aspirin therapy. The maintenance dose of ticagrelor used is 90 mg every 12 hours, combined with low-dose aspirin which is 100 mg given every 24 hours. The percentage of platelet aggregation in this study was measured using the Light Transmission Aggregometry (LTA) tool using the addition of a selected agonist, ADP

Phytochemical analysis and antioxidant activities using DPPH (1,1-Diphenyl-2-Picrylhydrazine) assay of Averrhoa bilimbi L. growing in Indonesia

To investigate Averrhoa bilimbi L. growing in Indonesia by phytochemical analysis and antioxidant activities using the 2,2-diphenyl-1-picrylhydrazine (DPPH) test. Methods: extraction was carried out by sequential maceration with n-hexane, chloroform, and methanol as solvent. Meanwhile, phytochemical analysis was carried out by various chemical tests that have been investigated in different in vitro methods. Furthermore, its antioxidant activity was assessed by the 2,2-diphenyl-1-picrylhydrazine (DPPH) test

Phytochemical Screening and Evaluation of Red Ginger Extracts on Aphrodisiac Activity

One of the breeding processes is influenced by reproduction factors. Herbal therapy can relieve male infertility, such as red ginger. This study aimed to determine the effect of red ginger extract on aphrodisiac activity. Methods: This study was designed to evaluate the effect of red ginger extract on aphrodisiac activity in Wistar rats. Twenty-five male Wistar rats and fifteen two-month-old females weighing 150-200 g were purchased and placed in cages at the Faculty of Health Sciences, University of Muhammadiyah Surabaya