Electronic transport, ionic activation energy and trapping phenomena in a polymer-hybrid halide perovskite composite

Abstract The exploitation of methylammonium lead iodide perovskite-polymer composites is a promising strategy for the preparation of photoactive thin layers for solar cells. The preparation of these composites is a simple fabrication method with improved moisture stability when compared to that of pristine perovskite films. To deepen the understanding of the charge transport properties of these films, we investigated charge carrier mobility, traps, and ion migration. For this purpose, we applied a combinatory measurement approach that proves how such composites can still retain an ambipolar charge transport nature and the same mobility values of the related perovskite. Furthermore, thermally stimulated current measurements revealed that the polymer influenced the creation of additional defects during film formation without affecting charge mobility. Finally, impedance spectroscopy measurements suggested the addition of starch may hinder ion migration, which would require larger activation energies to move ions in composite films. These results pave the way for new strategies of polymer-assisted perovskite film development

Is the Mandibular Condyle Involved in Medication-Related Osteonecrosis of the Jaw? Audit of a Single Tertiary Referral Center and Literature Review

Background: Medication-related osteonecrosis of the jaw (MRONJ) may manifest as exposed mandible bone. Recent reviews of the incidence of MRONJ report primarily as exposed cortical bone of the mandibular body, ramus, and symphysis with no reports of condylar involvement. Objective: The aim of this study is to analyze the topographical incidence of MRONJ, comorbidities, demographics data, and clinical characteristics of patients diagnosed with MRONJ between 2014 and 2019 in the Maxillo-Facial Surgery Department University of Campania "Luigi Vanvitelli", and compare these results with published reports. Methods: Data on 179 patients were collected for the study, including gender, age, underlying malignancy, medical history, and specific lesion location-identifying premaxilla and posterior sectors area involvement for the maxilla and symphysis, body, ramus, and condyle area for the mandible. A literature review was performed in order to compare our results with similar or higher sample sizes and find if any condylar involvement was ever reported. The research was carried out on PubMed database identifying articles from January 2003 to November 2020, where MRONJ site distribution was discussed, and data were examined to scan for condylar localization reports. Results: 30 patients had maxillary MRONJ, 136 patients had mandibular MRONJ, and 13 patients had lesions located in both maxilla and mandible. None of the patients reported condylar involvement, neither as a single site nor as an additional localization. Literature review results were coherent to our findings showing no mention of condylar MRONJ. Conclusion: Results do not show reports of condylar involvement in MRONJ. Although the pathophysiology of the disease has not been fully elucidated, two possible explanations were developed: the first one based on the condyle embryogenetic origin; the second one based on the bisphosphonate and anti-resorptive medications effects on the different vascular patterns of the mandible areas

Update on COVID-19 and Effectiveness of a Vaccination Campaign in a Global Context

The COVID-19 pandemic caused by SARS-CoV-2 remains a significant issue for global health, the economy, and society. When SARS-CoV-2 began to spread, the most recent serious infectious disease of this century around the world, with its high morbidity and mortality rates, it is understandable why such infections have generally been spread in the past, mainly from international travel movements. This perspective review aimed to provide an update for clinicians on the recent developments related to the microbiological perspectives in pandemics, diagnostics, prevention (such as the spread of a virus), vaccination campaigns, treatment options, and health consequences for COVID-19 based on the current literature. In this way, the authors attempt to raise awareness on the transversal nature of these challenges by identifying the main risk/vulnerability factors that the scientific community must face including our current knowledge on the virus capacity of the mechanism of entry into the cells, the current classifications of viral variants, the knowledge of the mathematical model on the spread of viruses (the possible routes of transmission), and the effectiveness of vaccination campaigns in a global context of pandemic, particularly from COVID-19, with a look at new or future vaccines

Post-surgery fluids promote transition of cancer stem cell- to-endothelial and AKT/mTOR activity, contributing to relapse of giant cell tumors of bone

Giant cell tumors of bone (GCTB) are rare sarcomas with a high rate of unpredictable local relapse. Studies suggest that surgical methods affect recurrence, supporting the idea that local disease develops from re-growth of residual cancer cells. To identify early prognostic markers of individual risk of recurrence, we evaluated the effect of post-surgery fluids from a cohort of GCTB patients on growth of primary and established sarcoma cell lines, and mice xenographts. Post-surgery fluids increased cell growth and enhanced expression of CD44++, the principal receptor for the extracellular matrix component hyaluronan and the mesenchymal stem marker CD117+. Cancer cells became highly invasive and tumorigenic, acquiring stemness properties, and activated AKT/mTOR pathway. Prolonged stimulation with post-surgery fluids down-regulated the mesenchymal gene TWIST1 and Vimentin protein, and transdifferentiated cells into tubule-like structures positive to the endothelial markers VE-Cadherin and CD31+. In mice, post-surgery fluids gave rise to larger and more vascularized tumors than control, while in patients AKT/mTOR pathway activation was associated with recurrence by logistic regression (Kaplan-Meier; P<0.001). These findings indicate that post-surgery fluids are an adjuvant in mechanisms of tumor regrowth, increasing stem cell growth and AKT/mTOR activity

Knowing the Biosphere: Documentation, Specimens, Archives, and Names Reveal Environmental Change and Emerging Pathogens

One Health programs and trajectories are now the apparent standard for exploring the occurrence and distribution of emerging pathogens and disease. By definition, One Health has been characterized as a broadly inclusive, collaborative, and transdisciplinary approach with connectivity across local to global scales, which integrates the medical and veterinary community to recognize health outcomes emerging at the environmental nexus for people, animals, plants, and their shared landscapes. One Health has been an incomplete model, conceptually and operationally, focused on reactive and response-based foundations, to limit the impact of emerging pathogens and emerging infectious diseases and, as such, lacks a powerful proactive capacity. A proactive, predictive One Health is necessary, emanating in part from geographically/taxonomically broad and temporally deep biological collections of pathogen-host assemblages. The DAMA protocol (Document, Assess, Monitor, Act), the operational extension of the Stockholm paradigm (SP), accomplishes this task by encompassing holistic and strategic biological sampling of reservoir host assemblages and pathogens at environmental interfaces and more extensively through resurveys, with development of informatics resources digitally linked to physical specimens held in publicly accessible museum biorepositories. Archives of specimens are the foundations for accumulating interrelated archives of information (the baselines against which change can be identified and tracked), with collections serving as fundamental resources for biodiversity informatics under the conceptual evolutionary and ecological umbrella of the SP. A cultural and conceptual transformation is essential among the diverse practitioners in the One Health community, one that recognizes the necessity of placing pathogens in an evolutionary, ecological, and environmental context by integrating specimens and associated informatics into an infrastructure and networks for actionable information. As a community, it is essential to abandon response-based business as usual while looking forward toward proactive transboundary approaches that maximize our conceptual and taxonomic view of diversity across interconnected planetary scales that influence the complexity of pathogen-host interfaces. Evolution, where the past always influences the present and the future, defines our trajectory, as the need for sustained archives that describe the biosphere becomes more acute with each passing day

Modeling the 2010 blast wave of the symbiotic-like nova V407 Cygni

(Abridged) The symbiotic-like binary Mira and nova V407 Cyg was observed in outburst on March 2010 and monitored in several wavelength bands. Here we report on multi-dimensional hydrodynamic simulations describing the 2010 outburst of V407 Cyg, exploring the first 60 days of evolution. The model takes into account thermal conduction and radiative cooling; the pre-explosion system conditions included the companion star and a circumbinary density enhancement. The simulations showed that the blast and the ejecta distribution are both aspherical due to the inhomogeneous circumstellar medium in which they expand; in particular they are significantly collimated in polar directions (producing a bipolar shock morphology) if the circumstellar envelope is characterized by an equatorial density enhancement. The blast is partially shielded by the Mira companion, producing a wake with dense and hot post-shock plasma on the rear side of the companion star; most of the X-ray emission produced during the evolution of the blast arises from this plasma structure. The observed X-ray lightcurve can be reproduced, assuming values of outburst energy and ejected mass similar to those of RS Oph and U Sco, if a circumbinary gas density enhancement is included in the model. In this case, the 2010 blast propagated through a circumbinary gas density enhancement with radius of the order of 40 AU and gas density \approx 10^6 cm^{-3} and the mass of ejecta in the outburst was M_{ej} \approx 2\times 10^{-7} M_{\odot} with an explosion energy E_{0} \approx 2\times 10^{44} erg. Alternatively, the model can produce a similar X-ray lightcurve without the need of a circumbinary gas density enhancement only if the outburst energy and ejected mass were similar to those at the upper end of ranges for classical novae, namely M_{ej} \approx 5\times 10^{-5} M_{\odot} and E_{0} \approx 5\times 10^{46} erg.Comment: 10 pages, 6 Figures; accepted for publication on MNRAS. Version with full resolution images can be found at http://www.astropa.unipa.it/~orlando/PREPRINTS/sorlando_v407cyg.pd

Two-step MAPbI3 deposition by low-vacuum proximity-space-effusion for high-efficiency inverted semitransparent perovskite solar cells

The innovative two-step Low Vacuum-Proximity Space Effusion (LV-PSE) method exploits the conversion of a textured PbI2 layer into MAPbI3 by adsorption–incorporation–migration of energetic MAI molecules, thus enabling a best efficiency of 17.5% in 150 nm thick layers

Marine climate change and environmental indicators from the Marine Core Service

In the framework of the Mediterranean Operational Oceanography Network (MOON, http://www.moon-oceanforecasting.eu) The Mediterranean Forecasting System (Pinardi et al., 2003) has started the design and development of services that include the routine production of environmental and climate indicators. A process of identifying user requirements has been started in collaboration with European Environment Agency and the indicators definition and implementation aim to take user requirements into account. The indicators are extensively used by EEA (EEA web page on indicators: http://themes.eea.europa.eu/indicators/). INGV has carried out an analysis on the possible improvements of existing indicators in use by EEA and on the development of new indicators based on Marine Core Services (MCS) products. The list of indicators includes: Temperature, Chlorophyll-a (from ocean colour), Ocean Currents and Transport, Salinity, Transparency, Sea Level, Sea Ice and Density. A critical analysis has been carried out to identify the relevance of the above-mentioned indicators for EU policies, their spatial and temporal coverage, their accuracy and their availability (Coppini et al., 2008). INGV in collaboration with CNR-ISAC are directly involved on the development of the indicators in the Mediterranean region and European Seas region the Temperature and Chlorophyll-a (Chl-a) products are the most suitable for an indicator development test phase. In particular the OO Chl-a product, deduced from satellite data, is able to contribute to the further development of the EEA Chl-a indicator on eutrohpication that is based on in-situ measurements (CSI023). For this indicator a development phase has been undertaken in 2008 and 2009 within the European Topic Center for Water (ETC-W) for EEA. The temperature indicators, developed with the support of MyOcean and Operational Oceanography community, consist of long time series (1870-Today) of SST anomaly able to describe ocean temperature increase due to climate change in the European Seas and on SST trends map of the last 25 years for the European Seas. These last two indicators have been included in the last 2008 EEA report on Impacts of Climate change in the European Seas (http://www.eea.europa.eu/publications/eea_report_2008_4). Moreover MFS re-analysis have been produced for the Mediterranean Sea and it consists of daily output of MFS-OPA hydrodinamic model (1/16 of degree horizontal resolution) that assimilates all available in situ and satellite observation for 1985 to 2007. This reanalysis product is used to detect temperature anomalies over the last 20 years in the coastal zone that could be related with environmental stresses. In addition to that we have also identified a Density indicator that appears relevant for the ecosystem health assessment in the coastal waters.PublishedBerlin, Germany3.7. Dinamica del clima e dell'oceanoope

Effectiveness and safety of filgotinib in rheumatoid arthritis: a real-life multicentre experience

Objectives: We investigated the effectiveness and safety of filgotinib in a real-life multicentre cohort of rheumatoid arthritis (RA) patients. Methods: RA patients were evaluated at baseline and after 12 and 24 weeks and were stratified based on previous treatments as biologic disease-modifying anti-rheumatic drug (bDMARD)-naive and bDMARD-insufficient responders (IR). Concomitant usage of methotrexate (MTX) and oral glucocorticoids (GC) was recorded. At each timepoint we recorded disease activity, laboratory parameters and adverse events. Results: 126 patients were enrolled. 15.8% were bDMARD-naive (G0), while 84% were bDMARD-IR (G1). In G0, 45% of patients were in monotherapy (G2) and 55% were taken MTX (G3). In G1, 50% of patients were in monotherapy (G4) and 50% used MTX (G5).A significant reduction in all parameters at 12 weeks was observed; in the extension to 24 weeks the significant reduction was maintained for patient global assessment (PGA), examiner global assessment (EGA), visual analogue scale (VAS) pain, VAS fatigue, disease activity score (DAS)28- C-reactive protein (CRP) and CRP values. Filgotinib in monotherapy showed better outcomes in bDMARD-naive patients, with significant differences for patient reported outcomes (PROs) and DAS28-CRP. At 12 weeks, low disease activity (LDA) and remission were achieved in a percentage of 37.2 % and 10.7 % by simplified disease activity index (SDAI), 42.6 % and 5.7 % by clinical disease activity index (CDAI), 26.8 % and 25.2 % by DAS28-CRP, respectively. A significant decrease in steroid dose was evidenced in all patients. We observed a major adverse cardiovascular event in one patient and an increase in transaminase in another. No infections from Herpes Zoster were reported. Conclusions: Our real-world data confirm the effectiveness and safety of filgotinib in the management of RA, especially in bDMARD-naive patients