The SST multidecadal variability in the Atlantic-Mediterranean region and its relation to AMO

Abstract Two sea surface temperature (SST) time series, the Extended Reconstructed SST version 3 (ERSST.v3) and the Hadley Centre Sea Ice and Sea Surface Temperature dataset (HadISST), are used to investigate SST multidecadal variability in the Mediterranean Sea and to explore possible connections with other regions of the global ocean. The consistency between these two time series and the original International Comprehensive Ocean–Atmosphere Dataset version 2.5 (ICOADS 2.5) over the Mediterranean Sea is investigated, evaluating differences from monthly to multidecadal scales. From annual to longer time scales, the two time series consistently describe the same trends and multidecadal oscillations and agree with Mediterranean ICOADS SSTs. At monthly time scales the two time series are less consistent with each other because of the evident annual cycle that characterizes their difference. The subsequent analysis of the Mediterranean annual SST time series, based on lagged-correlation analysis, multitaper method (MTM), and singular spectral analysis (SSA), revealed the presence of a significant oscillation with a period of about 70 yr, very close to that of the Atlantic multidecadal oscillation (AMO). An extension of the analysis to other World Ocean regions confirmed that the predominance of this multidecadal signal with respect to longer period trends is a unique feature of the Mediterranean and North Atlantic Ocean, where it reaches its maximum at subpolar latitudes. Signatures of multidecadal oscillations are also found in the global SST time series after removing centennial and longer-term components. The analysis also reveals that Mediterranean SST and North Atlantic indices are significantly correlated and coherent for periods longer than about 40 yr. For time scales in the range 40–55 yr the coherence between the Mediterranean and subpolar gyre temperatures is higher than the coherence between the Mediterranean SST and North Atlantic Oscillation (NAO) or AMO. Finally, the results of the analysis are discussed in the light of possible climate mechanisms that can couple the Mediterranean Sea with the North Atlantic and the Global Ocean

Air–Sea Interaction in the Central Mediterranean Sea: Assessment of Reanalysis and Satellite Observations

Air–sea heat fluxes are essential climate variables, required for understanding air–sea interactions, local, regional and global climate, the hydrological cycle and atmospheric and oceanic circulation. In situ measurements of fluxes over the ocean are sparse and model reanalysis and satellite data can provide estimates at different scales. The accuracy of such estimates is therefore essential to obtain a reliable description of the occurring phenomena and changes. In this work, air–sea radiative fluxes derived from the SEVIRI sensor onboard the MSG satellite and from ERA5 reanalysis have been compared to direct high quality measurements performed over a complete annual cycle at the ENEA oceanographic observatory, near the island of Lampedusa in the Central Mediterranean Sea. Our analysis reveals that satellite derived products overestimate in situ direct observations of the downwelling short-wave (bias of 6.1 W/m2) and longwave (bias of 6.6 W/m2) irradiances. ERA5 reanalysis data show a negligible positive bias (+1.0 W/m2) for the shortwave irradiance and a large negative bias (−17 W/m2) for the longwave irradiance with respect to in situ observations. ERA5 meteorological variables, which are needed to calculate the air–sea heat flux using bulk formulae, have been compared with in situ measurements made at the oceanographic observatory. The two meteorological datasets show a very good agreement, with some underestimate of the wind speed by ERA5 for high wind conditions. We investigated the impact of different determinations of heat fluxes on the near surface sea temperature (1 m depth), as determined by calculations with a one-dimensional numerical model, the General Ocean Turbulence Model (GOTM). The sensitivity of the model to the different forcing was measured in terms of differences with respect to in situ temperature measurements made during the period under investigation. All simulations reproduced the true seasonal cycle and all high frequency variabilities. The best results on the overall seasonal cycle were obtained when using meteorological variables in the bulk formulae formulations used by the model itself. The derived overall annual net heat flux values were between +1.6 and 40.4 W/m2, depending on the used dataset. The large variability obtained with different datasets suggests that current determinations of the heat flux components and, in particular, of the longwave irradiance, need to be improved. The ENEA oceanographic observatory provides a complete, long-term, high resolution time series of high quality in situ observations. In the future, more similar sites worldwide will be needed for model and satellite validations and to improve the determination of the air–sea exchange and the understanding of related processes

Processing techniques for metrological improvement of low-cost smart meter hardware solution for IEC 61000-4-7 Class I harmonics measurements

The work investigates the feasibility of harmonic analysis implementation on smart meter microcontroller devices, according to IEC 61000-4-30 Class A and IEC 61000-4-7 Class I requirements. The final aim was to evaluate to what extent Class I harmonic analysis can be integrated into existing low-cost hardware platforms for smart metering, which normally have limited hardware features, especially concerning the ADC and the possibility of varying the sampling frequency with high resolution, according to the power system signal frequency. An extended experimental characterization is carried out on a case study device, aimed at analyzing its performances in terms of both measurement accuracy and computational burden. To increase metrological ADC behavior and decrease computational costs, sampling strategies and optimized interpolation algorithm have been implemented and tested verifying the feasibility of harmonic analysis implementation on smart meter microcontroller devices, according to IEC 61000-4-30 Class A and IEC 61000-4-7 Class I requirements

Thin-shell plastic lenses for space and laboratory applications

We have identified an inexpensive, readily available, mechanically stable, extremely smooth, elastic, and mechanically uniform plastic suitable for thin film X-ray optics. Polyethylene terephthalate (PET) is easily deformed without losing its elastic properties or surface smoothness. Most important, PET can be coated with mono- or multilayers that reflect X-rays at grazing incidence. We have used these properties to produce X-ray optics made either as a concentric nest of cylinders or as a spiral. We have produced accurately formed shells in precisely machined vacuum mandresl or used a pin and wheel structure to form a continuously wound spiral. The wide range of medical, industrial and scientific applications for our technology includes: a monochromatic X-ray collimater for medical diagnostics, a relay optic to transport an X-ray beam from the target in a scanning electron microscop0e to a lithium-drifted silicon and microcalorimeter detectors and a satellite mounted telescope to collect celestial X-rays. A wide variety of mono- and multilayer coatings allow X-rays up to ~100 keV to be reflected. Our paper presents data from a variety of diagnostic measurements on the properties of the PET foil and imaging results form single- and multi-shell lenses

Thin-shell plastic lenses for space and laboratory applications

We have identified an inexpensive, readily available, mechanically stable, extremely smooth, elastic, and mechanically uniform plastic suitable for thin film X-ray optics. Polyethylene terephthalate (PET) is easily deformed without losing its elastic properties or surface smoothness. Most important, PET can be coated with mono- or multilayers that reflect X-rays at grazing incidence. We have used these properties to produce X-ray optics made either as a concentric nest of cylinders or as a spiral. We have produced accurately formed shells in precisely machined vacuum mandresl or used a pin and wheel structure to form a continuously wound spiral. The wide range of medical, industrial and scientific applications for our technology includes: a monochromatic X-ray collimater for medical diagnostics, a relay optic to transport an X-ray beam from the target in a scanning electron microscop0e to a lithium-drifted silicon and microcalorimeter detectors and a satellite mounted telescope to collect celestial X-rays. A wide variety of mono- and multilayer coatings allow X-rays up to ~100 keV to be reflected. Our paper presents data from a variety of diagnostic measurements on the properties of the PET foil and imaging results form single- and multi-shell lenses

Sea surface temperature intercomparison in the framework of the Copernicus Climate Change Service (C3S)

A joint effort between the Copernicus Climate Change Service (C3S) and the Group for High Resolution Sea Surface Temperature (GHRSST) has been dedicated to an intercomparison study of eight global gap-free Sea Surface Temperature (SST) products to assess their accurate representation of the SST relevant to climate analysis. In general, all SST products show consistent spatial patterns and temporal variability during the overlapping time period (2003-2018). The main differences between each product are located in western boundary current and Antarctic Circumpolar Current regions. Linear trends display consistent SST spatial patterns among all products and exhibit a strong warming trend from 2012 to 2018 with the Pacific Ocean basin as the main contributor. SST discrepancy between all SST products is very small compared to the significant warming trend. Spatial power spectral density shows that the interpolation into 1o spatial resolution has negligible impacts on our results. The global mean SST time series reveals larger differences among all SST products during the early period of the satellite era (1982-2002) when there were fewer observations, indicating that the observation frequency is the main constraint of the SST climatology. The maturity matrix scores, which present the maturity of each product in terms of documentation, storage, and dissemination but not the scientific quality, demonstrate that ESA-CCI and OSTIA SST are well documented for users' convenience. Improvements could be made for MGDSST and BoM SST. Finally, we have recommended that these SST products can be used for fundamental climate applications and climate studies (e.g. El Nino)

Adjuvant capecitabine in triple negative breast cancer patients with residual disease after neoadjuvant treatment: real-world evidence from CaRe, a multicentric, observational study

Background: In triple negative breast cancer patients treated with neoadjuvant chemotherapy, residual disease at surgery is the most relevant unfavorable prognostic factor. Current guidelines consider the use of adjuvant capecitabine, based on the results of the randomized CREATE-X study, carried out in Asian patients and including a small subset of triple negative tumors. Thus far, evidence on Caucasian patients is limited, and no real-world data are available. Methods: We carried out a multicenter, observational study, involving 44 oncologic centres. Triple negative breast cancer patients with residual disease, treated with adjuvant capecitabine from January 2017 through June 2021, were recruited. We primarily focused on treatment tolerability, with toxicity being reported as potential cause of treatment discontinuation. Secondarily, we assessed effectiveness in the overall study population and in a subset having a minimum follow-up of 2 years. Results: Overall, 270 patients were retrospectively identified. The 50.4% of the patients had residual node positive disease, 7.8% and 81.9% had large or G3 residual tumor, respectively, and 80.4% a Ki-67 >20%. Toxicity-related treatment discontinuation was observed only in 10.4% of the patients. In the whole population, at a median follow-up of 15 months, 2-year disease-free survival was 62%, 2 and 3-year overall survival 84.0% and 76.2%, respectively. In 129 patients with a median follow-up of 25 months, 2-year disease-free survival was 43.4%, 2 and 3-year overall survival 78.0% and 70.8%, respectively. Six or more cycles of capecitabine were associated with more favourable outcomes compared with less than six cycles. Conclusion: The CaRe study shows an unexpectedly good tolerance of adjuvant capecitabine in a real-world setting, although effectiveness appears to be lower than that observed in the CREATE-X study. Methodological differences between the two studies impose significant limits to comparability concerning effectiveness, and strongly invite further research

Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor–Targeted Therapy in Metastatic Colorectal Cancer

The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth factor receptor (EGFR) have expanded the range of treatment options for metastatic colorectal cancer. Initial evaluation of these agents as monotherapy in patients with EGFR-expressing chemotherapy-refractory tumors yielded response rates of approximately 10%. The realization that detection of positive EGFR expression by immunostaining does not reliably predict clinical outcome of EGFR-targeted treatment has led to an intense search for alternative predictive biomarkers. Oncogenic activation of signaling pathways downstream of the EGFR, such as mutation of KRAS, BRAF, or PIK3CA oncogenes, or inactivation of the PTEN tumor suppressor gene is central to the progression of colorectal cancer. Tumor KRAS mutations, which may be present in 35%–45% of patients with colorectal cancer, have emerged as an important predictive marker of resistance to panitumumab or cetuximab treatment. In addition, among colorectal tumors carrying wild-type KRAS, mutation of BRAF or PIK3CA or loss of PTEN expression may be associated with resistance to EGFR-targeted monoclonal antibody treatment, although these additional biomarkers require further validation before incorporation into clinical practice. Additional knowledge of the molecular basis for sensitivity or resistance to EGFR-targeted monoclonal antibodies will allow the development of new treatment algorithms to identify patients who are most likely to respond to treatment and could also provide rationale for combining therapies to overcome primary resistance. The use of KRAS mutations as a selection biomarker for anti-EGFR monoclonal antibody (eg, panitumumab or cetuximab) treatment is the first major step toward individualized treatment for patients with metastatic colorectal cancer