Empirical Evidence of the Metacognitive Model of Rumination and Depression in Clinical and Nonclinical Samples: A Systematic Review and Meta-Analysis

Rumination is considered a cognitive vulnerability factor in the development and maintenance of depression. The metacognitive model of rumination and depression suggests that the development of rumination and its association with depression partly depends on metacognitive beliefs. Two metacognitive beliefs about rumination have been identified: positive beliefs about its utility and negative beliefs about the uncontrollability and its negative social consequences. We conducted a systematic review and meta-analysis aimed: (1) to analyze the associations between metacognitive beliefs and rumination and depression; (2) to test the metacognitive model, using a Two-Stage Structural Equation Modeling approach (TSSEM). Literature search retrieved 41 studies. These 41 studies (N = 10,607) were included in the narrative synthesis and meta-analysis, and 16 studies (N = 4477) were comprised for the TSSEM. Results indicated metacognitive beliefs are associated with rumination and depression. Measures on metacognitive beliefs about rumination indicated that positive beliefs showed moderate associations with rumination (r = 0.50), and low with depression (r = 0.27); whereas negative beliefs showed moderate associations with both rumination (r = 0.46) and depression (r = 0.49). These results were consistent across studies using different instruments to measure metacognitive beliefs, and in both clinical and nonclinical samples. Moreover, results of the TSSEM analyses showed that the metacognitive model had a good fit. In sum, our results are in line with the metacognitive model of rumination and depression, highlighting that metacognitive beliefs are relevant factors to understand why people ruminate and get depressed. Future directions and clinical implications are discussed

Major depressive disorder following terrorist attacks: A systematic review of prevalence, course and correlates

<p>Abstract</p> <p>Background</p> <p>Terrorist attacks are traumatic events that may result in a wide range of psychological disorders for people exposed. This review aimed to systematically assess the current evidence on major depressive disorder (MDD) after terrorist attacks.</p> <p>Methods</p> <p>A systematic review was performed. Studies included assessed the impact of human-made, intentional, terrorist attacks in direct victims and/or persons in general population and evaluated MDD based on diagnostic criteria.</p> <p>Results</p> <p>A total of 567 reports were identified, 11 of which were eligible for this review: 6 carried out with direct victims, 4 with persons in general population, and 1 with victims and general population. The reviewed literature suggests that the risk of MDD ranges between 20 and 30% in direct victims and between 4 and 10% in the general population in the first few months after terrorist attacks. Characteristics that tend to increase risk of MDD after a terrorist attack are female gender, having experienced more stressful situations before or after the attack, peritraumatic reactions during the attack, loss of psychosocial resources, and low social support. The course of MDD after terrorist attacks is less clear due to the scarcity of longitudinal studies.</p> <p>Conclusions</p> <p>Methodological limitations in the literature of this field are considered and potentially important areas for future research such as the assessment of the course of MDD, the study of correlates of MDD or the comorbidity between MDD and other mental health problems are discussed.</p

Improved Photocatalytic H2 Evolution by Cobaloxime-Tethered Imidazole-Functionalized Periodic Mesoporous Organosilica

Molecular cobaloxime-based heterogeneous systems have attracted great interest during the last decades in light-driven hydrogen production. Here, we present a novel cobaloxime-tethered periodic mesoporous organosilica (PMO) hybrid (Im-EtPMO-Co) prepared through the immobilization of a molecular cobaloxime complex on the imidazole groups present in ethylene-bridged PMO. The successful assembly of a molecular cobaloxime catalyst via cobalt-imidazole axial ligation has been evidenced by several techniques, such as 13C NMR, Raman spectroscopy, ICP-MS, and XPS. The catalytic performance of Im-EtPMO-Co catalyst was essayed on the hydrogen evolution reaction (HER) under visible light in presence of a photosensitizer (Eosin Y) and an electron donor (TEOA). It showed an excellent hydrogen production of 95 mmol hydrogen at 2.5 h, which corresponded to a TON of 138. These results reflect an improved photocatalytic activity with respect to its homogenous counterpart [Co(dmgH)2(Im)Cl] as well as a previous cobaloxime-PMO system with pyridine axial ligation to the cobaloxime complex

Copper-complexed dipyridyl-pyridazine functionalized periodic mesoporous organosilica as heterogeneous catalyst for styrene epoxidation

A new heterogenous catalyst has been synthesized by immobilization of a copper complex on dipyridyl-pyridazine functionalized periodic mesoporous organosilica (dppz-vPMO). This ordered support was firstly prepared by a co-condensation reaction between vinyltriethoxysilane and 1,2-bis(trimethoxysilyl)ethane and further post-functionalized through a hetero Diels-Alder reaction with 3,6-di-2-pyridyl-1,2,4,5-tetrazine. Techniques such as XRD, N2 isotherms, TEM, 13C NMR, XPS and DRIFT, among others, were employed to characterize the surface functionalized materials. These results have proven the ordered mesostructure of the materials as well as the presence of novel nitrogen-chelating heterocyclic compounds in the pore surface after the post-modification process. Additionally, it has been confirmed the successful anchoring of a copper complex on the dipyridyl-pyridazine (dppz) ligands. The resulting material was evaluated as heterogenous catalyst in the epoxidation of styrene using tert-butylhydroperoxide (TBHP) as oxidant. Under optimized reaction conditions, Cu@dppz-vPMO showed a high styrene conversion (86.0 %) and a remarkable selectivity to styrene oxide (41.9 %). Indeed, this catalyst provided excellent catalytic results in terms of stability, reaction rate, conversion and selectivity compared to other bipyridine-like copper catalysts

Recomendaciones para la informatización de los servicios de neonatología

El objetivo es proporcionar el marco para la recopilación de datos en el área de la salud de los recién nacidos que permitan la armonización de la asistencia sea cual sea su lugar de nacimiento. Para ello es necesario conocer la población atendida y la mayor dificultad es la ausencia de un sistema de recopilación de datos y de unos estándares asistenciales para todas las condiciones del recién nacido. Es imprescindible disponer de un registro único en el que se recojan los principales datos perinatales y neonatales de todos los recién nacidos. La Sociedad Española de Neonatología (SEN) debe ser el depositario y responsable de la base de datos, que debe cumplir todas las exigencias legales de privacidad y confidencialidad. A nivel de cada centro es posible conocer el peso relativo de la afección atendida por grupos de diagnósticos relacionados (DRG) y los resultados desde el aspecto de calidad asistencial. Mediante análisis comparativos (estudios de benchmarking,. . .) es posible establecer las pautas de diagnóstico y tratamiento. Es necesario conocer la población de recién nacidos atendida y definir criterios de diagnóstico y tratamiento para mejorar la calidad asistencial. La SEN desea dirigirse a los responsables asistenciales de los centros hospitalarios para pedirles su apoyo y colaboración en la puesta en marcha de estas recomendaciones

Protective Effect of Oral BCG and Inactivated Mycobacterium bovis Vaccines in European Badgers (Meles meles) Experimentally Infected With M. bovis

[EN] In Europe, badgers (Meles meles) are recognized as major tuberculosis (TB) reservoir hosts with the potential to transmit infection to associated cattle herds. Recent studies in Spain have demonstrated that vaccination with a heat-inactivated Mycobacterium bovis vaccine (HIMB) successfully protects captive wild boar and red deer against progressive disease. The aim of this study was to evaluate the efficacy of two oral vaccines against TB in a badger model: the live-attenuated M. bovis bacillus Calmette-Guérin BCG vaccine (Danish strain) and a HIMB vaccine. Twenty-four badgers were separated in three treatment groups: oral vaccinated with live BCG (108 CFU, n = 5), oral vaccinated with HIMB (107 CFU, n = 7), and unvaccinated controls (n = 12). All badgers were experimentally infected with M. bovis (103 CFU) by the endobronchial route targeting the right middle lung lobe. Throughout the study, clinical, immunological, pathological, and bacteriological parameters of infection were measured. Both vaccines conferred protection against experimental TB in badger, as measured by a reduction of the severity and lesion volumes. Based on these data, HIMB vaccination appears to be a promising TB oral vaccine candidate for badgers in endemic countries.SIThis study was funded by a grant from Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), reference number RTA2014-00002-C02 (FEDER co-funded), the Principado de Asturias, PCTI 2018–2020 (GRUPIN: IDI2018-000237 and FEDER), and Departamento de Desarrollo Económico e Infraestructuras del Gobierno Vasco. This study was also funded by Ministerio de Ciencia, Innovación y Universidades (MCIU), the Agencia Estatal de Investigación (AEI) reference project RTI2018-096010-B-C21 and Fondo Europeo de Desarrollo Regional (FEDER). DEFRA also funded APHA staff for their participation in the study and for the purchase of BCG from Statens Serum Institute (Copenhagen, Denmark).Authors thank Cristina Blanco Vázquez, Miriam Martínez de Egidua, Xeider Gerrikagoitia, Valentin Wacheux, Amaia Etxezarreta, Olalla Torrontegui, Si Palmer, Bernat Pérez de Val, and Enric Vidal for their collaboration during the processing of samples, Gareth Williams for providing BCG and Colin Birch for helping in calculating the disease burden scores. Authors also thank Kevin P. Dalton for critically reviewing the manuscript