2,522 research outputs found
Coating thickness and coverage effects on the forces between silica nanoparticles in water
The structure and interactions of coated silica nanoparticles have been
studied in water using molecular dynamics simulations. For 5 nm diameter
amorphous silica nanoparticles we studied the effects of varying the chain
length and grafting density of polyethylene oxide (PEO) on the nanoparticle
coating's shape and on nanoparticle-nanoparticle effective forces. For short
ligands of length and repeat units, the coatings are radially
symmetric while for longer chains () the coatings are highly
anisotropic. This anisotropy appears to be governed primarily by chain length,
with coverage playing a secondary role. For the largest chain lengths
considered, the strongly anisotropic shape makes fitting to a simple radial
force model impossible. For shorter ligands, where the coatings are isotropic,
we found that the force between pairs of nanoparticles is purely repulsive and
can be fit to the form where is the separation
between the center of the nanoparticles, is the radius of the
silica core, and is measured to be between 2.3 and 4.1.Comment: 20 pages, 6 figure
The Role of Cardiac Magnetic Resonance in the Evaluation of Patients Presenting with Suspected or Confirmed Acute Coronary Syndrome
Cardiac magnetic resonance imaging (CMR) has an important emerging role in the evaluation and management of patients who present with symptoms concerning for acute coronary syndrome (ACS). This paper discusses the role of CMR in the emergency department setting, where CMR can aid in the early and accurate diagnosis of non-ST elevation ACS in low and intermediate risk patients. For those with confirmed myocardial infarction (MI), CMR provides comprehensive prognostic information and can readily diagnose structural complications related to MI. Furthermore, the pattern of late gadolinium enhancement (LGE) seen on CMR can help determine the etiology of cardiac injury in the subset of patients presenting with ACS who do not have obstructive coronary artery disease by angiography
T1 Mapping Basic Techniques and Clinical Applications
AbstractIn cardiac magnetic resonance (CMR) imaging, the T1 relaxation time for the 1H magnetization in myocardial tissue may represent a valuable biomarker for a variety of pathological conditions. This possibility has driven the growing interest in quantifying T1, rather than just relying on its effect on image contrast. The techniques have advanced to where pixel-level myocardial T1 mapping has become a routine component of CMR examinations. Combined with the use of contrast agents, T1 mapping has led an expansive investigation of interstitial remodeling in ischemic and nonischemic heart disease. The purpose of this review was to introduce the reader to the physical principles of T1 mapping, the imaging techniques developed for T1 mapping, the pathophysiological markers accessible by T1 mapping, and its clinical uses
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