MAM14 Immunotherapy New Modality Treat Autoimmune Disorder

There is no safe single treatment for autoimmune disorders until this writing. This new modality is challenging this notion with safe no toxic method named MAM14 immunotherapy. This new method have been tried on several types of autoimmune disorders in the last 25 years in our lab at Kuwait University Faculty of Medicine. In this article we demonstrate the difference of MAM14 on four out of the 14 autoimmune disorder studied compared to control who received conventional chemotherapy.  Data accumulated of 1400 patients compared to 1400 controls. For the present article the sample we chose 10 patients treated with MAM14 for each disease studied compared to 10 control- patients from the same sickness but treated by conventional immunosuppressant chemotherapy, Cyclosporine, Methotrexate ,Tacrolimus or steroid.  MAM14 immunotherapy In brief is vaccination of patients by allogeneic stressed peripheral blood lymphocytes.   Peripheral Blood Lymphocytes isolated from venous whole blood on Ficoll-Paque centrifugation.Cultured for 24 hours in sterile physiological enriched media. Vaccinated subcutaneously into forearm of patients. Vaccination given every 4 weeks for four visits.  4 autoimmune disorder included in this study namely insulin dependent diabetes mellitus, rheumatoid arthritis, multiple sclerosis and anterior uveitis. Total 40 patients-  treated by MAM14 method 10 patients of each disease compared to 10 control patients of the same disorder but on conventional chemotherapy. Prism Graph pad biostatistical package was used for data analysis.  Data accumulated showed significant improvement in signs and symptoms of the present autoimmune disorders studied. Namely insulin dependent diabetes mellitus, rheumatoid arthritis, multiple sclerosis and anterior uveitis.  MAM14 immunotherapy showed superior improvement and safety on the long run compared to control patients who receive conventional immunosuppressant.Mechanism postulated that culturing cells in vitro cause shedding of antigens, these antigens direct autoreactive pathogenic T cells convert to regulatory protective T cells in the presence of peripheral stem cells leading to restoring tolerance and switching off autoimmunity reaction.

IgA Nephropathy Improved by a New Modality: MAM14 Immunotherapy: A Case Report in Kuwait

A 45 Year-old- Kuwaiti female with a case of IgA nephropathy (IgA N) was studied from 2002 to 2014 at Mubarak Hospital. The chief complaint was hematuria. In the first year she was given a conventional corticosteroid regimen. Her parameters at this stage are used as controls for the remainder of the study. She was treated with FK506 immunosuppressant capsules in the second year and vaccinated with allogeneic peripheral blood lymphocytes (PBL) in the third year. This study includes the following parameters: serum creatinine, serum albumin, IgA level, and 24-hour urine protein. In the first year the patient was only on corticosteroid, in the second year only FK506, and in the third year was treated only with PBL vaccination. A booster dose of vaccine was administered after approximately 5 years. The patient’s significant improvements after PBL vaccination have persisted for 9 years. The mechanism postulated for this kind of immunotherapy is induction of novel therapeutic antigens, including heat shock protein (HSP), that interact with autoreactive T or B cells in the recipient. The result is T regulatory cells (T-reg) claimed to be responsible for shifting T-cell detrimental function to regulatory function, hence preventing the pathological production and deposition of IgA in the kidney. Data accumulated from our lab, but not yet published, demonstrates that MAM14 immunotherapy ameliorates symptoms and signs of certain autoimmune disorders

MAM14 Immunotherapy Protocol: The Dream of Ophthalmologist, Became at Your Door. This Protocol Can Treat Autoimmune Uveitis.

Uveitis doesn't have to involve a lifelong treatment course (C Stephen Foster). In this article we replaced conventional steroid and other immunosuppressant treatment by safe and new immunomodulation called MAM14 immunotherapy protocol, designed to treat uveitis. Our objective is to replace steroid and other immunosuppresant with safe effective immunomodulation method.   As a first trial to study this protocol, we choose one hundred twelve female uveitis patients called: experimental group; their age range between 13-15 years old, treated by MAM14 immunotherapy, which is briefly, paternal stressed allogeneic lymphocyte vaccination given subcutaneously to their daughters. Compared to 120 female control group uveitis patients age range between 12-16 years old received routine prednisone eye drops (Pred Forte). Results for the Slit lamp microscope showed that the experimental group demonstrates remarkable improvement duration of treatment four to nine months. Improvement lasted for ten years. No side effect noted during experiment and until this writing compared to control. Pachymeter showed no degradation of cornea and slit lamp showed no lymphocyte infiltration. On the other hand, symptoms and signs of control group patients is up and down. Lymphocyte infiltration is variable and degradation of cornea is prominent. As a conclusion we can say that it is time for autoimmune uveitis attack to be controlled immunologically

Why do Saudi Nurses Leave Bedside Nursing: Findings from a Pilot Study

Aim: To explore the salient factors that account for Saudi nurses leaving bedside nursing to work in other fields of nursing.   Method: A non-experimental descriptive quantitative design was used to answer the research question of this pilot study. A valid and reliable questionnaire was used as an instrument for data collection. A snowball / purposive sample was used to collect the data from 46 Saudi nurses who had left bedside nursing in three hospitals in the Aseer region in southwest of Saudi Arabia. Data were analyzed by a professional statistician using descriptive statistics.   Findings: The salient factors for Saudi nurses’ decision to leave bedside nursing that were identified included: income (including allowances and financial incentives), administrative regulations, job satisfaction, and other miscellaneous factors   Conclusion: Although this pilot study has several limitations, the findings indicate that health care planners and policy staff, and nursing leaders in the Kingdom of Saudi Arabia need to develop strategies to address the issues expressed by Saudi nurses in regard to bedside nursing, particularly the need to improve (a) financial allowances and incentive systems, (b) the bedside work environment (e.g., by decreasing weekly working hours), and (c) the image of bedside Saudi nurses in the eyes of Saudi society.   Keywords: Saudi Nurses, Pilot Study, Bedside Nursing &nbsp

Isolation of filter passing bacteria from a range of dental clinic surfaces

Filter passing bacteria have been isolated from a variety of natural environments, appearing as a mixture of Gram-positive and Gram-negative, as well as nano-forms and wall-free species. In this study, filter passing bacteria were isolated from surfaces located in various dental departments at the College of Dentistry, King Saud University Hospital. Surface samples were obtained by using Q-tip swabs, with ten different surfaces being sampled in each clinic during pre-patient and post-patient visits. Filterable bacteria (using 0.4 and 0.2 micron filters, but not 0.1 micron filter) were isolated, being mainly Gram-positive cocci. Isolation results of filterable bacteria were compared before and after patient treatment in the clinic. More frequently, filter passing bacteria were isolated on clinic surfaces after patient treatment. The results show that dental settings are contaminated with filterable bacteria which may act as a reservoir for the wider contamination of hospital environments

Anesthesia with Respiratory Therapist, Nursing and Radiology Team Participation in Dental Practice: Review

The use of general anesthesia can make it easier for dental professionals to treat patients who, in the absence of this therapy, would be unable to obtain dental care themselves. Furthermore, the readiology team and the respiratory therapist, in conjunction with the nursing staff, will work together to ensure that the dental operation is carried out in a comfortable and risk-free manner. According to the opinions and preferences of dental practitioners, the type of local anesthetic that was most generally desired was lidocaine. On the other hand, the type of topical anesthetic that was most preferred was benzocaine in gel form. Furthermore, among Saudi dentists, the precise body weight was the factor that was utilized the most frequently in the process of determining the dosage of local anesthesia

Clinical Laboratory Test And Radiological Methods In Diagnosis Of Orthopedics Condition: Role Of Nurses In Facilitating These Procedures: Review

Despite the fact that the fields of radiological imaging, pathology, and laboratory analysis appear to be very different from one another, the medical diagnostic information that these sources provide has a great deal in common with one another. This information can be utilized effectively by encouraging the sharing of quantitative and qualitative results through the utilization of modern information technology processes. Developing the capacities of informatics to coordinate the analysis of pictures produced by clinical radiological imaging, anatomic cellular and molecular pathology, and data gained from the analysis of biomarkers in the laboratory; this method is based on the development of these capabilities. This skill helps to stimulate the formation of novel "integrated diagnostics" in orthopedic disorders, and nursing plays an important part in the technical aspects of many orthopedic operations

Importance And Roles Of Clinical Pharmacist, Nurses And Social Workers, Dietitian With The Psychologist In Performing Excellent Patient Care

Professionals in the healthcare industry have a favorable attitude toward psychological cases, as well as the role of clinical pharmacists in the right therapeutic management and education of patients, as well as a vital part in optimizing the dosage of psychotic drugs. On the other hand, there is a potential area for improvement that is connected to the empowerment of the clinical service with privilege and personnel, as well as the elevation of consciousness regarding the growth of the service in ambulatory settings. In addition, the significant roles that social workers and dietitians play in the management of patients, in conjunction with the function that psychologists play

Inverse Correlation between Stress and Adaptive Coping in Medical Students

BACKGROUND: Medical students in their academic years are generally under stress but very few studies revealed the relationship between the stress and how the students manage to adapt these stressful conditions. AIM: The aim of the study was to investigate the levels of stress and their adaptive coping in the 1st 3 years medical students and also to determine the factors associated with adaptive coping strategies. METHODS: This is a descriptive cross-sectional study conducted on 441 medical students of Qassim University from September-October 2019. First 3 years medical students were randomly selected and their stress levels or adaptive coping strategies were determined by general health questionnaire (GHQ-12) and strategies coping mechanisms (SCM), respectively. The 5-points Likert scale was used for scoring and the data obtained were further validated by DASS and Brief COPE scales. RESULTS: Out of 441 medical students, 39.2% agreed to participate. The data showed that the level of stress among students was highest during their 1st year academic blocks, followed by 2nd and 3rd year students. Interesting, the adaptive coping among them was found highest during the academic blocks of 3rd year students, followed by the 2nd and 1st year students. Importantly, female students showed better adaptation against stress. Students living with their parents avoided stress in better ways as compared to those who were living alone. CONCLUSION: This is the first study that shows an inverse correlation between the stress and adaptive coping in medical students of Qassim University. The data concluded that adaptation of stress in the 3rd-year students was the highest followed by 2nd and 1st year medical students. Moreover, female students adapted well against stress and students living alone showed worse adaptation of stress

Efficacy Of Digital Operating Room Technology , Role Of Nursing, Anesthesia And Radiology Team In OR Safety

Nowadays, operating rooms (ORs) are inefficient and overcrowded, and the turnover between cases is frequently lengthy and varied. In addition, the turnover rate is not consistent. The introduction of new technologies and devices into an environment that is already technologically complex is frequently done in a completely random manner. Both the data and photographs pertaining to patients are not integrated effectively or displayed in a timely manner. The system is put under additional strain as a result of the lack of integration of technology and information, which leads to further decreases in both efficiency and effectiveness. As a consequence, this may have an effect on the prices and the safety of patients. In order to improve efficiency, enhance safety, and lower the cost of care, it is vital to strengthen the integration of high technology, as well as to engage in teamwork, improve communication and coordination among services, providers, and personnel. Despite the fact that these daily realities are present, the conventional operating room is undergoing a transformation as a result of the introduction of new technology and paradigms into the clinical setting. Nursing, anesthesia and radiology team play a very important role in OR safety, as they form an excellent team in all aspects of collaboration