12 research outputs found
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
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- Alexandru TM
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- Alonso Martin JJ
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- Ruiz RLF
- Saaiman JA
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- Sabatino K
- Sabbah E
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- Sakagami S
- Sakalyte G
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- Saminsk K
- Sanabria Perez ES
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- Sheldon W
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- Shetty S
- Shi X
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- Shinde R
- Shinke T
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- Shoukfeh M
- Shustov S
- Shvarts Y
- Sijbrands EJG
- Sikic J
- Silva PGMDB
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- Silveira JA
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- Sime I
- Simic D
- Simon T
- Simonis G
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- Singsaas EG
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- Sionis D
- Sirisena T
- Siu DCW
- Skonieczny G
- Skorski M
- Skoumas I
- Slapikas R
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- Soopold U
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- Sotty M
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- Souza WKSB
- Soward A
- Sparby JA
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- Spinar J
- Sporn D
- Spriggs D
- Sritara P
- Stambuk K
- Staneta P
- Stanislavchuk M
- Stankovic A
- Starcevic B
- Starmer G
- Stasek J
- Stasiewski A
- Steg PG
- Steg PG
- Steiner S
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- Stewart R
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- Stratmann M
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- Subkovas E
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- Suligoj NC
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- Sumner A
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- Sundelin T
- Sundram PS
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- Sussex B
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- Sy RAG
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- Taguchi S
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- Tesloianu DN
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- Thao H
- Thew S
- Tirador L
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- Todorov GV
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- Tomala T
- Tomulic V
- Tonnessen G
- Torstensson I
- Toursarkissian N
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- Treasure C
- Tretyakova TV
- Trevelyan J
- Triana MAU
- Tricoci P
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- Trotter C
- Tsai W-C
- Tse H-F
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- Ungi I
- Ural E
- Ushakov O
- Utsu N
- Vahula V
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- Valdivielso P
- Valdovinos PCM
- Valdovinos PCM
- Valgimigli M
- Valiris J
- Vallejo GS
- Vallejos JA
- Van Der Wal RMA
- Van Der Zwaan CC
- Van Diepen SFP
- Van Huysduynen-Monraats PSH
- Van Zyl LJ
- Vardas P
- Vardi G
- Vargas Gonzales RJ
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- Vatutin M
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- Vejar M
- Velcheva ES
- Verdel GJE
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- Vico ML
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- Videbaek L
- Vidotti MH
- Vidovich M
- Viergever EP
- Viigimaa M
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- Vikman S
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- Vincendet M
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- Vishnevsky AY
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- Vo A
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- Voevoda MI
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- Vrolix MCM
- Vulic D
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- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
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- Weissbrodt M
- Welka S
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- Westerhausen D
- Whitaker J
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- Wilkinson P
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- Winkelmann B
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- Xu Y
- Yagensky A
- Yakushin S
- Yan AT-K
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- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zapata G
- Zdravko B
- Zea Nunez CA
- Zeiher AM
- Zeiher AM
- Zhang R
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheleznyy V
- Zheng Y
- Zheng Z
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- Zhu C
- Zhu H
- Zhu J
- Zirlik A
- Zizka J
- Zobouyan I
- Zong W
- Zrazhevsky K
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Policy mobilities and the sociomateriality of U.S. offshore aquaculture governance
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
A survey of 460 supernumerary teeth in Brazilian children and adolescents
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Characterization of electrocardiogram changes throughout a marathon
- Author
- A Lucia
- AJ Siegel
- BD Nearing
- BD Nearing
- BD Nearing
- BD Nearing
- Clifton Callaway
- D Webner
- David Hostler
- David Salcido
- DR Adam
- E Hynynen
- EA Raeder
- EB Fortescue
- EF Chakravarty
- H Heidbuchel
- H Tsuji
- J Abdulla
- JE Smith
- JH Kim
- JM Pastore
- K Martinmaki
- M Chinushi
- M Malik
- MP Tulppo
- MP Tulppo
- N Mousavi
- NA Estes 3rd
- NG Kavesh
- PJ Schwartz
- R Perini
- RE Kleiger
- RL Verrier
- RL Verrier
- Ronald Roth
- S Sarna
- Serina McEntire
- SM Narayan
- T Nieminen
- Task Force of the European Society of Cardiology the North American Society of Pacing Electrophysiology
- TG Neilan
- Vanessa Franco
- Y Yamamoto
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Achieving urban food security through a hybrid public-private food provisioning system: the case of Nanjing, China
- Author
- A Goldman
- A Morales
- A Morales
- A Morales
- A Swindale
- A Veeck
- B Lowery
- C Huang
- C Mele
- C Poulton
- C Rocha
- C Rocha
- C Slade
- DA Freedman
- DD Weatherspoon
- E Hulbrock
- E Rouviere
- G Salcido
- J Battersby
- J Crush
- J Huang
- J Humphrey
- JJL Candel
- Jonathan Crush
- K Pothukuchi
- M Marsilio
- M Pensado-Leglise
- MG Martinez
- MHURD (Ministry of Housing and Urban-Rural Development of China)
- MR Islam
- MSM Sharif
- N Fava
- National Research Council (US)
- NB Kurland
- QF Zhang
- RC Sadler
- RE Walker
- S Peyton
- S Scott
- S-C Ho
- Steffanie Scott
- T Reardon
- T Reardon
- T Zhong
- Taiyang Zhong
- V McCracken
- V Ruelas
- VFD Corte
- WH Hamm
- X Ma
- Xianjin Huang
- YY Ang
- Z Si
- Z Si
- Zhenzhong Si
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Probiotic Potential of Lactobacillus paracasei CT12 Isolated from Water Kefir Grains (Tibicos)
- Author
- A Baumgartner
- A Gil-RodrĂguez
- A Jeronymo-Ceneviva
- A Kumar
- A Lo Curto
- A Marroki
- A Pospiech
- AA Argyri
- Adrián Hernández-Mendoza
- Audry Peredo-Lovillo
- B Halliwell
- B Kos
- B Ou
- C Kotzamanidis
- C Wu
- D Castro-RodrĂguez
- D Hill
- D Laureys
- D Martarelli
- D Relman
- EFSA-FEEDAP
- F Nejati
- FA Ayeni
- G Blandino
- Gloria Dávila-Ortiz
- H Jonsson
- Haydee Eliza Romero-Luna
- HE Romero-Luna
- HE Romero-Luna
- Humberto Hernández-Sánchez
- I Rowland
- J Takebayashi
- JE Aguilar-Toalá
- K Angmo
- K Nishiyama
- K Nishiyama
- K Ramiah
- M Begley
- M Pineiro
- M Yang
- MP Arena
- MS Silva
- NM de la Fuente-Salcido
- O Cortés-Zavaleta
- P HĂĽtt
- Patricia Isidra Cauich-Sánchez
- R Georgieva
- R Re
- R Thombre
- Rosa MarĂa Ribas-Aparicio
- VD Valeriano
- W Charteris
- X Ma
- Y Tuo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Assessment of goat milk-derived potential probiotic L. lactis AMD17 and its application for preparation of dahi using honey
- Author
- A Arvouet-Grand
- A Duda-Chodak
- A Meda
- A Monteagudo-Mera
- Ajay Kumar Manhar
- AK Manhar
- Anindhya S. Das
- Anjan Borah
- B Re Del
- C Dunne
- Charu Lata Mahanta
- CS Brennan
- Devabrata Saikia
- F Addeo
- F Ferreres
- G Floros
- G Moorthy
- H Li
- H Yadav
- H Yadav
- HTH Nguyen
- I Bustos
- J Felsenstein
- J Ren
- J Yang
- JK Kaushik
- K Lisak
- K Tamura
- K Todoriki
- Kuldeep Gupta
- L Varga
- M Al-Mamary
- M Kimura
- Manabendra Mandal
- MC Collado
- MEC Whetstine
- N Gheldof
- N Ishibashi
- N Shah
- NK Lee
- NM Fuente-Salcido De la
- NP Shah
- P Andrade
- P Duboc
- PA Maragkoudakis
- PJ Agaliya
- PS Handley
- R Singh
- Raju Roy
- RPS Oliveira
- Rupak Mukhopadhyay
- S Ahmad
- S Ammor
- S Kaewnopparat
- S Mitra
- SVN Vijayendra
- T Faye
- T GarcĂa-Cayuela
- V Xanthopoulos
- VL Singleton
- W Brand-Williams
- W Wang
- WJ Kelly
- Z Tong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ship breaking or scuttling? A review of environmental, economic and forensic issues for decision support
- Author
- A Tewari
- AB Andersen
- AB Hasan
- B Kirkpatrick
- B Kudłak
- B Singh
- BE Scarfe
- Briac Beilvert
- C Diego
- C Kelse
- C Morales-Caselles
- C Xue
- CD MacDonald
- CJ Brown
- D Goto
- D Langlet
- D Wilhelmsson
- DA Devault
- DA Feary
- Damien A. Devault
- DC Reed
- DF Rocha Da
- DJ Sheehy
- DS Saini
- ER Pianka
- F Bulleri
- F Demaria
- F Guichard
- FW Oehme
- G Hodgson
- G Kowalewska
- G Muller
- G Neser
- G Richards
- G Tiwary
- G Ulfstein
- H Davis
- H Misra
- H Schuhmacher
- HA Simon
- HM Abdullah
- I Allegrini
- I Khan
- ID Macleod
- J Burt
- J Burt
- J Cunningham
- J Rogowska
- J-M Thierry
- JA Bohnsack
- JA Bohnsack
- JA Tørnes
- JJ Polovina
- JK McElroy
- JK Petersen
- JM Gonzalez-Correa
- JN Huckins
- K Ho
- K Pazdro
- K Tomioka
- KG Shirlal
- L Oldenski
- L-G Faksness
- LP Jager
- LV Harris
- LW Kelly
- M Aktaruzzaman
- M Baine
- M Biggeri
- M Bogdaniuk
- M Bunderson-Schelvan
- M Cohen
- M Hoch
- M Kara
- M Kara
- M Odabasi
- M Srinivasa Reddy
- M Srinivasa Reddy
- M Stammers
- M Umeyama
- M Voorde Ten
- MA Hixon
- MD Needham
- MG Chapman
- MJ Kaiser
- ML Wells
- MN Courtice
- MO Rivett
- MS Hossain
- N Akten
- N Selmi
- N Watanuki
- N Zaidi
- OE Frihy
- OE Williamson
- P Garud
- P Ghosh
- P Pandey
- P Rousmaniere
- P Treeck Van
- P Treeck Van
- PA Olsvik
- PAG Nazareno
- PD Petersen
- Peter Winterton
- PI Macreadie
- PM D'Costa
- PRD Williams
- PWJ Bartrip
- R Chester
- R Chowdhury
- R Naagarajan
- R Ranasinghe
- R Tiwari
- R Weber
- RA Mowatt
- RB Ditton
- RC Fitzhardinge
- RE Brock
- RE Brown
- RE Salcido
- RF Bopp
- RJ Diaz
- RM Mridula
- S Basha
- S Bhattacharjee
- S Jadhav
- S Karim
- S Karim
- S Knapp
- S Singh
- S Sonak
- S Vaselli
- SF Ho
- SJ Boc
- SW Karickhoff
- T Matilainen
- T Missiaen
- T Shibata
- TC Haab
- TG Puthucherril
- TK Vyas
- TM Glasby
- V Patel
- V Rossi
- VR Leeworthy
- W Davison
- WA Lewis
- WS Beckett
- Y-C Chang
- YM Aydin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Acne Models
- Author
- A Chatelus
- A Howard
- A Weissmann
- A Weissmann
- AJ Morgan
- AM Kligman
- AM Kligman
- AW Lucky
- BC Beehler
- C Luderschmidt
- CC Zouboulis
- CC Zouboulis
- CC Zouboulis
- CC Zouboulis
- CC Zouboulis
- CG Burkhart
- CH Lapière
- D Lecaque
- E Kaszynski
- EG Weirich
- F Bernerd
- F Bernerd
- F Neumann
- F Ye
- FG Ferguson
- FJG Ebling
- G Noto
- G Noto
- G Plewig
- G Plewig
- GB Marit
- H Akamatsu
- H Gollnick
- H Matsumura
- H Uno
- HPM Gollnick
- J Karasek
- JA Mezick
- JJ Loux
- JJ Yourick
- JP Sundberg
- JR Matias
- JR Matias
- K Chakrabarty
- K Fukuda
- K Motoyoshi
- K Motoyoshi
- K Motoyoshi
- KM Tramposch
- L Fort-Lacoste
- L Xia
- LH Kligman
- LM Young De
- LM Young De
- LS Sauter
- M Aricò
- M Bouclier
- M Fritsch
- M González-Diddi
- M Ito
- M Ito
- M Morohashi
- M Seiberg
- M Shamoto
- M Tsukada
- MI Foreman
- MJ Petersen
- N Goto
- N Hunziker
- N Orentreich
- OG Mitchell
- OH Mills
- P Zheng
- PA Wuest
- PJ Wauben-Penris
- R Guy
- R Guy
- R Salcido
- R Stadler
- RA Ferrari
- RE Ashton
- RH Lesnik
- RL Rosenfield
- RL Rosenfield
- RM Schwartzman
- S González
- S González
- S Imakado
- SH Mann
- SL Yankell
- SL Yankell
- T Battmann
- T Kimura
- T Maeda
- T Seki
- T Seki
- TI Doran
- TI Doran
- TJ Franz
- W Voigt
- X Feng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study