Heme oxygenase-1 as a modulator of intestinal inflammation development and progression

Indexación: Scopus.Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease. © 2018 Sebastián, Salazar, Coronado-Arrázola, Schultz, Vallejos, Berkowitz, álvarez-Lobos, Riedel, Kalergis and Bueno.https://www.frontiersin.org/articles/10.3389/fimmu.2018.01956/ful

Biosorción de Cd (II) y Pb (II) de soluciones acousas en residuos agrícolas de Phaseolus vulgaris L.: optimización, cinética, isotermas y desorción

Industrial activities are the most common cause of water contamination by heavy metals, which endanger the quality of water resources and human health, due to their bioaccumulation capacity and consequent biomagnification. For this reason, the removal of metals from e uents before their discharge into the receiving water bodies is of crucial importance. This is why, in the present investigation, the biosorption processes of Cd (II) and Pb (II) in Phaseolus vulgaris L. (bean) agricultural residues (stems, leaves and leaf sheaths) were optimized. The influence of pH, biosorbent doses and initial concentration levels of metallic ions was evaluated using the response surface methodology (RSM). Quadratic models were developed for the percent removal of Cd (II) and Pb (II). Optimal biosorption conditions were attained at pH = 4.3, a 7.4 g/L biosorbent dose and an initial 9.14 mg/L concentration of each metal, achieving percent removals of 87.70 and 95.58% for Cd (II) and Pb (II), respectively. The FT-IR characterization showed that the functional groups involved in adsorption would be in the range of 2300 to 2400 cm-1. The biosorption kinetics were described by the pseudo first order model and the equilibrium data was adjusted to the Freundlich isotherm. An approximate desorption of 98% of Cd (II) and Pb (II) was achieved. The Phaseolus vulgaris L. residue showed a great biosorption capacity of Cd (II) and Pb (II) simultaneously.Las actividades industriales son la fuente más común de contaminación del agua por metales pesados que resultan ser un peligro para la calidad de los recursos hídricos y la salud humana, debido a su capacidad de bioacumulación y consecuente biomagnificación, por tal motivo, la remoción de metales de efluentes antes de ser vertidos a los cuerpos receptores es de crucial importancia. Razón por la cual, en la presente investigación se optimizó el proceso de biosorción de Cd (II) y Pb (II) en residuos agrícolas de Phaseolus vulgaris L. (frejol) que constó de tallos, hojas y vainas. Se evaluó la influencia del pH, dosis de biosorbente y concentración inicial del ion metálico mediante la metodología de superficie de respuesta (RSM). Se desarrollaron modelos cuadráticos para las remociones porcentuales de Cd (II) y Pb (II). Las condiciones óptimas de biosorción fueron pH=4.3, dosis de biosorbente 7.4 g/L y una concentración inicial de cada metal de 9.14 mg/L logrando remociones de 87.70 y 95.58% para Cd (II) y Pb (II), respectivamente. La caracterización por FT-IR mostró que, los grupos funcionales involucrados en la adsorción estarían en el rango de 2300 a 2400 cm-1. La cinética de biosorción fue descrita por el modelo de pseudo primer orden y los datos en equilibrio se ajustaron a la isoterma de Freundlich. Se logró una desorción aproximada de 98% de Cd (II) y Pb (II). El residuo de Phaseolus vulgaris L. mostró gran capacidad de biosorción de Cd (II) y Pb (II) simultáneamente.Campus Arequip

Petrografia, geoquímica e geocronologia dos granitos patrimônio Santo Antônio e São Domingos (Suíte Cunhaporanga, Paraná, Sudeste do Brasil)

The Patrimônio Santo Antônio and São Domingos Granites are located in the northwest portion of the Itaiacoca Belt, which is part of the Apiaí Terrane (or tectonic domain), a segment of the southern Ribeira Belt, the major tectonic unit of the Mantiqueira Province (Southeast Brazil). These granites are related to the Cunhaporanga Granitic Suite and are intrusive into metasedimentary rocks of the Itaiacoca Group. The plutons are represented mainly by porphyritic monzogranites, with rare occurrences of syenogranites. The porphyritic monzogranites are ferroan to magnesian, high-K, alkali-calcic, and metaluminous to peraluminous. Trace elements patterns of the granites, which have been locally affected by hydrothermal alteration, suggest an association with magmas emplaced in a late- to post-tectonic setting. The geochemical signatures suggest a mantle source enriched in incompatible elements remobilized from the oceanic crust during subduction. The geochronological age of the Patrimônio Santo Antônio Granite (589 ± 6 Ma, zircon, U-Pb SHRIMP) indicates that the magmatism associated with these plutons occurred between the final stages of evolution of the Cunhaporanga Granitic Suite (ca. 650 to 590 Ma) and the emplacement of the post-orogenic and anorogenic plutons of the Apiaí Domain (ca. 590 to 570 Ma).Os Granitos Patrimônio Santo Antônio e São Domingos localizam-se na porção noroeste da Faixa Itaiacoca constituinte do Terreno (ou domínio tectônico) Apiaí segmento do Cinturão Ribeira Meridional da Província Mantiqueira localizada no sudoeste do Brasil. Ambos estão relacionados com a Suíte Granítica Cunhaporanga e são intrusivos em rochas metassedimentares do Grupo Itaiacoca. São constituídos por ocorrências esparsas de sienogranitos e majoritariamente por monzogranitos porfiríticos de caráter metaluminoso a peraluminoso, álcali-cálcico de alto K e comportamento ferroso a magnesiano. O comportamento dos elementos traços, por vezes afetado por alteração hidrotermal, é sugestivo de magmatismo pós a tardi-colisional, com assinaturas geoquímicas que sugerem origem a partir de manto enriquecido pela adição de elementos incompatíveis remobilizados de crosta oceânica durante subducção. A idade geocronológica obtida para o Granito Patrimônio Santo Antônio (589 ± 6 Ma, zircões, U-Pb, SHRIMP) situa o magmatismo destes plútons entre os estágios finais de evolução da Suíte Granítica Cunhaporanga (ca. 650 a 590 Ma) e da colocação dos plútons pós-orogênicos e anorogênicos do Domínio Apiaí (ca. 590 a 570 Ma)

Milagro limits and HAWC sensitivity for the rate-density of evaporating Primordial Black Holes

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On the sensitivity of the HAWC observatory to gamma-ray bursts

We present the sensitivity of HAWC to Gamma Ray Bursts (GRBs). HAWC is a very high-energy gamma-ray observatory currently under construction in Mexico at an altitude of 4100 m. It will observe atmospheric air showers via the water Cherenkov method. HAWC will consist of 300 large water tanks instrumented with 4 photomultipliers each. HAWC has two data acquisition (DAQ) systems. The main DAQ system reads out coincident signals in the tanks and reconstructs the direction and energy of individual atmospheric showers. The scaler DAQ counts the hits in each photomultiplier tube (PMT) in the detector and searches for a statistical excess over the noise of all PMTs. We show that HAWC has a realistic opportunity to observe the high-energy power law components of GRBs that extend at least up to 30 GeV, as it has been observed by Fermi LAT. The two DAQ systems have an energy threshold that is low enough to observe events similar to GRB 090510 and GRB 090902b with the characteristics observed by Fermi LAT. HAWC will provide information about the high-energy spectra of GRBs which in turn could help to understanding about e-pair attenuation in GRB jets, extragalactic background light absorption, as well as establishing the highest energy to which GRBs accelerate particles

Track D Social Science, Human Rights and Political Science

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd

Measurement of the cross section for isolated-photon plus jet production in pp collisions at √s=13 TeV using the ATLAS detector

The dynamics of isolated-photon production in association with a jet in proton–proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb−1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon–jet invariant mass and the scattering angle in the photon–jet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements

Measurement of the View the tt production cross-section using eμ events with b-tagged jets in pp collisions at √s = 13 TeV with the ATLAS detector

This paper describes a measurement of the inclusive top quark pair production cross-section (σtt¯) with a data sample of 3.2 fb−1 of proton–proton collisions at a centre-of-mass energy of √s = 13 TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electron–muon pair in the final state. Jets containing b-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two b-tagged jets are counted and used to determine simultaneously σtt¯ and the efficiency to reconstruct and b-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be: σtt¯ = 818 ± 8 (stat) ± 27 (syst) ± 19 (lumi) ± 12 (beam) pb, where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented

A search for resonances decaying into a Higgs boson and a new particle X in the XH → qqbb final state with the ATLAS detector

A search for heavy resonances decaying into a Higgs boson (H) and a new particle (X) is reported, utilizing 36.1 fb−1 of proton–proton collision data at collected during 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. The particle X is assumed to decay to a pair of light quarks, and the fully hadronic final state is analysed. The search considers the regime of high XH resonance masses, where the X and H bosons are both highly Lorentz-boosted and are each reconstructed using a single jet with large radius parameter. A two-dimensional phase space of XH mass versus X mass is scanned for evidence of a signal, over a range of XH resonance mass values between 1 TeV and 4 TeV, and for X particles with masses from 50 GeV to 1000 GeV. All search results are consistent with the expectations for the background due to Standard Model processes, and 95% CL upper limits are set, as a function of XH and X masses, on the production cross-section of the resonance

Search for TeV-scale gravity signatures in high-mass final states with leptons and jets with the ATLAS detector at sqrt [ s ] = 13TeV

A search for physics beyond the Standard Model, in final states with at least one high transverse momentum charged lepton (electron or muon) and two additional high transverse momentum leptons or jets, is performed using 3.2 fb−1 of proton–proton collision data recorded by the ATLAS detector at the Large Hadron Collider in 2015 at √s = 13 TeV. The upper end of the distribution of the scalar sum of the transverse momenta of leptons and jets is sensitive to the production of high-mass objects. No excess of events beyond Standard Model predictions is observed. Exclusion limits are set for models of microscopic black holes with two to six extra dimensions