Non-quasiparticle states in Co2_2MnSi evidenced through magnetic tunnel junction spectroscopy measurements

We investigate the effects of electronic correlations in the full-Heusler Co$_2$MnSi, by combining a theoretical analysis of the spin-resolved density of states with tunneling-conductance spectroscopy measurements using Co$_2$MnSi as electrode. Both experimental and theoretical results confirm the existence of so-called non-quasiparticle states and their crucial contribution to the finite-temperature spin polarisation in this material.Comment: Repalced Fig. 1. of PRL, 100, 086402 (2008), better k-space resolution for DOS around Fermi energ

Optically induced magnetization dynamics and variation of damping parameter in epitaxial Co2MnSi Heusler alloy films

Copyright © 2010 The American Physical SocietyAll-optical pump-probe measurements of magnetization dynamics have been performed upon epitaxial Co2MnSi(001) Heusler alloy thin films annealed at temperatures of 300, 400, and 450 °C. An ultrafast laser-induced modification of the magnetocrystalline anisotropy triggers precession which is detected by time-resolved magneto-optical Kerr effect measurements. From the damped oscillatory Kerr rotation, the frequency and relaxation rate of the precession is determined. Using a macrospin solution of the Landau-Lifshitz-Gilbert equation the effective fields acting upon the sample magnetization are deduced. This reveals that the magnetization is virtually independent of the annealing temperature while the fourfold magnetocrystalline anisotropy decreases dramatically with increasing annealing temperature as the film structure changes between the B2 and L21 phases. From the measured relaxation rates, the value of the apparent Gilbert damping parameter is found to depend strongly upon the static field strength and in-plane static field orientation. The variation of the apparent damping parameter is generally well reproduced by an inhomogeneous broadening model in which the presence of B2 and L21 phases leads to a large dispersion of the magnetocrystalline anisotropy. However, for the sample annealed at a temperature of 300 °C, the lack of a detailed fit to the data suggests that the apparent anisotropy of the apparent damping parameter might alternatively arise due to a network of dislocations with fourfold symmetry

Self-Similar Random Processes and Infinite-Dimensional Configuration Spaces

We discuss various infinite-dimensional configuration spaces that carry measures quasiinvariant under compactly-supported diffeomorphisms of a manifold M corresponding to a physical space. Such measures allow the construction of unitary representations of the diffeomorphism group, which are important to nonrelativistic quantum statistical physics and to the quantum theory of extended objects in d-dimensional Euclidean space. Special attention is given to measurable structure and topology underlying measures on generalized configuration spaces obtained from self-similar random processes (both for d = 1 and d > 1), which describe infinite point configurations having accumulation points

Epitaxial contact Andreev reflection spectroscopy of NbN/Co₂FeSi layered devices

We investigated the spin polarization P of Co-based Heusler alloy Co2FeSi by epitaxial contact Andreev reflection (ECAR) spectroscopy using epitaxially grown superconductor NbN and Heusler alloy Co2FeSi layered devices. Ferromagnetic Co2FeSi possesses the highest Curie temperature (TC ? 1100 K) and the largest spontaneous magnetic moment (ps ? 6 μB) in the class of Heusler alloys. The ECAR measurements revealed that the P value of Co2FeSi was 54 ± 2% with a finite barrier parameter Z, indicating that an intrinsic P value in ECAR spectroscopy would exceed reported values in point-contact Andreev reflection spectroscopy. We therefore established not only the epitaxial integration of ferromagnetic Co2FeSi with superconductor NbN on an MgO substrate but also the fabrication and evaluation techniques of their ECAR devices. This highly versatile superconducting spintronic system enables fundamental superconducting spintronic studies, and it is also a candidate for practical superconducting spintronic devices

Algorithms for locating extremely conserved elements in multiple sequence alignments

<p>Abstract</p> <p>Background</p> <p>In 2004, Bejerano <it>et al</it>. announced the startling discovery of hundreds of "ultraconserved elements", long genomic sequences perfectly conserved across human, mouse, and rat. Their announcement stimulated a flurry of subsequent research.</p> <p>Results</p> <p>We generalize the notion of ultraconserved element in a natural way from extraordinary human-rodent conservation to extraordinary conservation over an arbitrary set of species. We call these "Extremely Conserved Elements". There is a linear time algorithm to find all such Extremely Conserved Elements in any multiple sequence alignment, provided that the conservation is required to be across all the aligned species. For the general case of conservation across an arbitrary subset of the aligned species, we show that the question of whether there exists an Extremely Conserved Element is <it>NP</it>-complete. We illustrate the linear time algorithm by cataloguing all 177 Extremely Conserved Elements in the currently available 44-vertebrate whole-genome alignment, and point out some of the characteristics of these elements.</p> <p>Conclusions</p> <p>The <it>NP</it>-completeness in the case of conservation across an arbitrary subset of the aligned species implies that it is unlikely an efficient algorithm exists for this general case. Despite this fact, for the interesting case of conservation across all or most of the aligned species, our algorithm is efficient enough to be practical. The 177 Extremely Conserved Elements that we catalog demonstrate many of the characteristics of the original ultraconserved elements of Bejerano <it>et al</it>.</p

Lyso-GM2 Ganglioside: A Possible Biomarker of Tay-Sachs Disease and Sandhoff Disease

To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex) B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances

Twin and family studies indicate that the timing of primary tooth eruption is highly heritable, with estimates typically exceeding 80%. To identify variants involved in primary tooth eruption we performed a population based genome-wide association study of ‘age at first tooth’ and ‘number of teeth’ using 5998 and 6609 individuals respectively from the Avon Longitudinal Study of Parents and Children (ALSPAC) and 5403 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966). We tested 2,446,724 SNPs imputed in both studies. Analyses were controlled for the effect of gestational age, sex and age of measurement. Results from the two studies were combined using fixed effects inverse variance meta-analysis. We identified a total of fifteen independent loci, with ten loci reaching genome-wide significance (p<5x10−8) for ‘age at first tooth’ and eleven loci for ‘number of teeth’. Together these associations explain 6.06% of the variation in ‘age of first tooth’ and 4.76% of the variation in ‘number of teeth’. The identified loci included eight previously unidentified loci, some containing genes known to play a role in tooth and other developmental pathways, including a SNP in the protein-coding region of BMP4 (rs17563, P= 9.080x10−17). Three of these loci, containing the genes HMGA2, AJUBA and ADK, also showed evidence of association with craniofacial distances, particularly those indexing facial width. Our results suggest that the genome-wide association approach is a powerful strategy for detecting variants involved in tooth eruption, and potentially craniofacial growth and more generally organ development