60 research outputs found
Protective Effects of Walnut Extract Against Amyloid Beta Peptide-Induced Cell Death and Oxidative Stress in PC12 Cells
Amyloid beta-protein (AĪ²) is the major component of senile plaques and cerebrovascular amyloid deposits in individuals with Alzheimerās disease. AĪ² is known to increase free radical production in neuronal cells, leading to oxidative stress and cell death. Recently, considerable attention has been focused on dietary antioxidants that are able to scavenge reactive oxygen species (ROS), thereby offering protection against oxidative stress. Walnuts are rich in components that have anti-oxidant and anti-inflammatory properties. The inhibition of in vitro fibrillization of synthetic AĪ², and solubilization of preformed fibrillar AĪ² by walnut extract was previously reported. The present study was designed to investigate whether walnut extract can protect against AĪ²-induced oxidative damage and cytotoxicity. The effect of walnut extract on AĪ²-induced cellular damage, ROS generation and apoptosis in PC12 pheochromocytoma cells was studied. Walnut extract reduced AĪ²-mediated cell death assessed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) reduction, and release of lactate dehydrogenase (membrane damage), DNA damage (apoptosis) and generation of ROS in a concentration-dependent manner. These results suggest that walnut extract can counteract AĪ²-induced oxidative stress and associated cell death
Ćcido linolĆ©ico conjugado: efeitos no perfil lipĆdico e na composiĆ§Ć£o corporal de camundongos exercitados
An investigation on the effects of late intake valve closing and exhaust gas recirculation in a single-cylinder research diesel engine in the low-load condition
Simultaneous improvement of exhaust emissions and fuel consumption by optimization of combustion chamber shape of a diesel engine
Non-contact wide-angled visualization with chandelier-assisted scleral buckling for primary uncomplicated rhegmatogenous retinal detachment
Enzyme renaturation to higher activity driven by the sol-gel transition: Carbonic anhydrase
Improvement of dispersion stability and characterization of upconversion nanophosphors covalently modified with PEG as a fluorescence bioimaging probe
- ā¦