6 research outputs found
Human hepatocyte growth factor levels in patients undergoing thoracic operations
KISA, Ucler/0000-0002-8131-6810WOS: 000234635100013PubMed: 16387938Human hepatocyte growth factor (hHGF) is the most potent mitogen identified for alveolar type II cells, and may have other important functions in the repair of the alveolar epithelium and compensatory lung growth. A study was conducted to evaluate the changes of serum hHGF levels in patients who underwent thoracic surgical procedures. The patients comprised 17 males and 14 females with a mean age of 47.1 +/- 13.5 yrs, who underwent either lung resection (LR group) or nonlung resection (norLR group) thoracic procedures. The changes of hHGF levels were analysed in the pre- and post-operative periods in both groups. The pre-operative hHGF levels did not differ between the LR and the nonLR groups, which were 333.2 +/- 72.9 pg center dot mL(-1) and 343.6 +/- 125.3 pg center dot mL(-1), respectively. The hHGF levels in the LR group significantly increased up to 433.6 +/- 128.1 pg center dot mL(-1) and 430.8 +/- 128.2 pg center dot mL(-1) in post-operative days 1 and 3, respectively. However, the same levels in the nonLR group appeared as 333.2 +/- 77.0 pg center dot mL(-1) and 311.9 +/- 73.0 pg center dot mL(-1), respectively. In conclusion, the increases of serum human hepatocyte growth factor levels following pulmonary resection may imply the important role of human hepatocyte growth factor in lung regeneration or compensatory lung growth in humans
Analysis of pulmonary hydatidosis according to their segmentary locations
The objective of this analysis is to compare the pulmonary locations of lung hydatid cysts and their size with respect to their locations with available literature. The records of 82 patients who were operated for pulmonary hydatid cysts between January 2001 and December 2005 were retrospectively evaluated. One hundred eleven cysts detected in 82 patients were placed into 2 groups as those located in the right lung (group A, 55 cysts) and those located in the left lung (group B, 56 cysts), and the segments involved were investigated. The gender distribution of the patients was 40 male and 42 female, with a mean age of 35.2 ± 17.64 years (range: 7-82 years). No difference was detected with respect to involvement between the 2 lungs (P = 0.285). The most commonly involved segment was the posterior basal segment of the lower lobe with 15 cysts (27.3%) from group A and 20 cysts (35.7%) from group B. No involvement of the lower lobe medial basal and anteromedial basal segments was observed. The most common surgical procedures applied were cystotomy and capitonnage. The findings of the study showed that pulmonary hydatidosis were located in some segments of the lungs more frequently, primarily in the posterior segment of the lower lobe and the apicoposterior segment of the upper lobe. In addition, the higher prevalence of giant cysts in the lower lobe and their ability to produce symptoms only after being enlarged suggest a role of mechanisms other than elasticity of the lungs. © 2008 Lippincott Williams & Wilkins, Inc
Ultrastructural Changes In Pneumocyte Type Ii Cells Following Traumatic Brain Injury In Rats
Objective: We aimed to demonstrate the time-dependent ultrastructural changes in pneumocyte type II cells following brain injury, and to propose an electron microscopic scoring model for the damage. Methods: Forty Wistar-Albino female rats weighing 170-200 g were used. The rats were allocated into five groups. The first group was the control and the second was the craniotomy without trauma. The others were trauma groups. Weight-drop method was used for achieving head trauma. Samples were obtained from the right and left pulmonary lobes at 2-, 8-, and 24-h intervals after transcardiac perfusion. An electron microscopic scoring model was used to reveal the changes. Results: There were no ultrastructural pathological findings pointing to lung injury in any rat of the control groups. There was intense intracellular oedema in type II pneumocyte and interstitial oedema in the adjacent tissue in trauma groups. Oedema in mitochondria and dilatation in both smooth endoplasmic reticulum and Golgi apparatus was more evident in the 8- and 24-h trauma groups. The chromatin dispersion was disintegrated in the nucleus in all trauma groups. Scores of all trauma groups were significantly different from the controls (P < 0.05). All trauma groups were different from each other at significant levels (P < 0.05 for each trauma groups). Conclusions: The data suggested that ultrastructural damage is obvious at 2 h and deteriorates with time. The electron microscopic scoring model worked well in depicting the traumatic changes, which were supported by lipid peroxidation. Further experiments are needed to determine the exact outcome after brain death model. (C) 2004 Elsevier B.V. All rights reserved.WoSScopu