Literature and Cinema: My Doubts, My Challenges and My Hope

Panel: Writers on Fil

Purification and Analysis of Folate-dye Conjugate

The folate receptor has achieved great importance for use in targeted drug delivery and in vitro and in vivo diagnostic assays. The folate receptor (FR) is over-expressed on several cancer cell types and activated macrophages, but exists in relatively low abundance on the surface of non-cancerous tissue and non inflammatory cells. This unique attribute is the hallmark of folate-targeted methodologies allowing the diagnostic agent and/or drug to be ferried to the specific disease sites while preventing “off target” effects in normal tissues. Protein toxins, chemotherapeutic agents, radioimaging agents, magnetic resonance imaging (MRI) contrast agents liposomes with entrapped drugs, radiotherapeutic agents, and immunotherapeutic agents are all in current stages of development. Although several folate-based dyes have been reported, simple and detailed synthetic and purification methods for these conjugates have not been reported. More importantly, several new photostable dyes are now commercially available that have not been tested as folate-based imaging agents. In tandem with the synthesis of these new folate dyes, High Performance Liquid Chromatography (HPLC) purification/analysis by diode array and mass spectrometry will need to be undertaken in order to confirm the identity of the compounds. Thus, our objective is to develop a new folate-based dye and the corresponding HPLC methods for the purification and analysis of this conjugate. Once synthesized, we have several column types of varying lengths, diameters, particle sizes, (we recently acquired ~ 20 “state of the art” columns from industrial sources) and several HPLC’s at our disposal to analyze the compound (via retention time and mass spectrum)

ગુજરાતના મીની સિમેન્ટ એકમોની જુદી જુદી કામગીરીના પાસાંઓનો અભ્યાસ

Not availabl

Effectiveness of Work-Card and Programmed Learning as a Self Learning Technique with Reference to Teaching of English Grammar

There is extreme dearth of an effective teachers and better schools in our country. In the country like India, the teachers are so much over loaded with work that they cannot perform their teaching functions effectively. On the other hand, the scientific inventions have influenced every aspect of human life; even our kitchen has been mechanized. That’s way our education process could not remain untouched by it. New methods and techniques in education are increasingly making an impact on the traditional approach to teaching and learning. Among the new approaches and innovations that have gained great acceptance in recent years are works card and programmed learning. In this regard, the researcher in the present study developed the work card material and the programmed learning material as the self learning material and examined its effectiveness on English grammar achievement

A case report on generalized pemphigus vulgaris treated with rituximaba

Background: Pemphigus vulgaris has an obscure etiology; the presence of autoantibodies is coherent with an autoimmune disease. Rituximab a monoclonal antibody that specifically targets the CD20 antigen of B lymphocytes, has arisen as a novel treatment approach for pemphigus vulgaris.  Case presentation: A 39-year-old male patient presented with a three-month history of mouth ulcers, poor oral hygiene accompanied with heavy tobacco smoking and alcohol consumption. He was diagnosed with pemphigus vulgaris. The disease gradually progressed to involve other body parts. The patient had shown partial improvement after conventional therapy (oral cefuroxime, oral prednisolone with azathioprine) and was later on successfully treated with rituximab. After 90 days of follow-up, no future recurrence was observed. Conclusion: With this case, the authors would like to aware other clinicians of the potential use of rituximab in treating pemphigus vulgaris, especially when the conventional therapy fails

Medication discrepancies in late-stage chronic kidney disease.

Background: Late-stage chronic kidney disease (LS-CKD) can be defined by glomerular filtration rate (GFR) 0-30 mL/min. It is a period of risk for medication discrepancies because of frequent hospitalizations, fragmented medical care, inadequate communication and polypharmacy. In this study, we sought to characterize medication discrepancies in LS-CKD. Methods: We analyzed all patients enrolled in Northwell Health\u27s Healthy Transitions in LS-CKD program. All patients had estimated GFR 0-30 mL/min, not on dialysis. Medications were reviewed by a nurse at a home visit. Patients\u27 medication usage and practice were compared with nephrologists\u27 medication lists, and discrepancies were characterized. Patients were categorized as having either no discrepancies or one or more. Associations between patient characteristics and number of medication discrepancies were evaluated by chi-square or Fisher\u27s exact test for categorical variables, and two-sample Results: Seven hundred and thirteen patients with a median age of 70 (interquartile range 58-79) years were studied. There were 392 patients (55.0% of the study population) with at least one medication discrepancy. The therapeutic classes of medications with most frequently occurring medication discrepancies were cardiovascular, vitamins, bone and mineral disease agents, diuretics, analgesics and diabetes medications. In multivariable analysis, factors associated with higher risk of discrepancies were congestive heart failure [odds ratio (OR) 2.13; 95% confidence interval (CI) 1.44-3.16; P = 0.0002] and number of medications (OR 1.29; 95% CI 1.21-1.37; P \u3c 0.0001). Conclusions: Medication discrepancies are common in LS-CKD, affect the majority of patients and include high-risk medication classes. Congestive heart failure and total number of medications are independently associated with greater risk for multiple drug discrepancies. The frequency of medication discrepancies indicates a need for great care in medication management of these patients

Expert consensus on the management of acne in India

Acne, a common cutaneous disorder, is estimated to affect a significant proportion of the population at some point in their lifetime. It is one of the most common presentations reported in dermatological consultations in India. Treatment options for acne include topical, oral and procedural therapies. Patients with mild acne can be treated with topical therapies; however, those with moderate to severe acne require systemic cure. Oral antibiotic treatment, hormonal therapies and isotretinoin are the mainstay systemic therapies for acne. Additionally, procedural therapeutic modalities in dermatology include chemical peels, laser therapy, micro needling techniques, to name a few. Scientific advances are continually improving knowledge of acne and contributing to refinement of treatment options. Hence, it is vital for clinicians to regularly update their clinical practice patterns to reflect current standard. An experts’ panel discussion involving dermatologists from across India was conducted, to outline a practical approach for the management of acne. The present consensus document focuses on the assessment of acne, use of topical treatments, role of systemic therapy and procedures in treating acne and post-inflammatory hyperpigmentation. It also emphasizes the role of patient education and counselling on prophylactic and treatment strategies in acne management

Application Security Testing to Support Digital-Based Cultural Ecosystem in Jogja Smart Province

The Jogja Smart Province (JSP) is a framework for using IT to encourage regional cooperation to assist in resolving specific strategic challenges or difficulties. Additionally, JSP supports the growth of potential in Yogyakarta’s Special Region. Several digital apps, including mobile and web-based ones, support JSP. These applications are crucial to actualizing the five JSP aspects of smart living, culture, society, environment, and governance. However, several significant issues, such as cyberattacks on JSP applications, pose a danger to the long-term viability of JSP. To do penetration testing of JSP-owned applications, the Department of Electrical Engineering and Informatics at the Vocational College of Universitas Gadjah Mada is conducting this community participation initiative. The Communication and Informatics Office of the Special Region of Yogyakarta permitted to handle JSP apps, is a partner in this community involvement initiative. Applications including Jogja Istimewa, Visiting Jogja, e-Prima, BiroHukum, Paperless, Jogjaplan, LPSE, Peladen, Sadewa, Jogjaprov, and Simpeg2 are among those targeted for penetration testing. The potential flaws detected in JSP applications can be found by performing penetration testing on these apps. In addition, several recommendations are made to strengthen JSP applications’ resistance to future cyberattacks. Therefore, this activity can improve the security of the users’ data and directly impact the community

STUDY OF THE PRESCRIPTION PRACTICES FOR MALARIA TREATMENT AND PROPHYLAXIS AMONG GOVERNMENT AND PRIVATE MEDICAL PRACTITIONERS IN BHAVNAGAR CITY

Objective: The objectives of the stud were 1)to compare the prescription practices of government and private medical practitioners in malaria treatment and prophylaxis in light of guidelines prescribed by NIMR and NVBDCP; and 2) to document the mechanism used by Gujarat’s health department to disseminate information regarding changes in treatment guidelines for malaria Methods: Out of 68 government doctors 34 doctors were randomly selected to obtain detail for this study. 2 areas with comparative low API Sardarnagar and Chitra were selected and 2 areas with more API Kaliyabid and Vadva were selected for this study. Doctors of private sector serving in above area were selected randomly by lottery method. Total 54 private practitioners were selected for the study which gives 9, 15, 30 private practitioners of MD, MBBS, AYUSH respectively. Results: A total of 88 medical practitioners were interviewed for this study who were allied with general treatment of fever cases. Out of 88 medical practitioners 34 (38.64%) work in Government & 54 (61.37%) work in private sectors. out of 34 government doctors most of 85.29% (n=29) were prescribe antimalarials according to guideline for 14 days only 41.86% (n=18) AYUSH were follow drug policy which was much less than the allopathic practitioners who prescribe according to guideline 70.97% (n=22) of MBBS and 85.71%(n=12) of MD