A systematic study of Zr and Sn isotopes in the Relativistic Mean Field theory

The ground-state properties of Zr and Sn isotopes are studied within the relativistic mean field theory. Zr and Sn isotopes have received tremendous attention due to various reasons, including the predicted giant halos in the neutron-rich Zr isotopes, the unique feature of being robustly spherical in the region of $^{100}$Sn $\sim$ $^{132}$Sn and the particular interest of Sn isotopes to nuclear astrophysics. Furthermore, four (semi-) magic neutron numbers, 40, 50, 82 and 126, make these two isotopic chains particularly important to test the pairing correlations and the deformations in a microscopic model. In the present work, we carry out a systematic study of Zr and Sn isotopes from the proton drip line to the neutron drip line with deformation effects, pairing correlations and blocking effects for nuclei with odd number of neutrons properly treated. A constrained calculation with quadrupole deformations is performed to find the absolute minimum for each nucleus on the deformation surface. All ground-state properties, including the separation energies, the odd-even staggerings, the nuclear radii, the deformations and the single-particle spectra are analyzed and discussed in detail.Comment: the final version to appear in Modern Physics Letters A. more figures, discussions, and references added. the data remain unchange

Evaluation of the Total Design Method in a survey of Japanese dentists

BACKGROUND: This study assessed the application of the Total Design Method (TDM) in a mail survey of Japanese dentists. The TDM was chosen because survey response rates in Japan are unacceptably low and the TDM had previously been used in a general population survey. METHODS: Four hundred and seventy eight dentist members of the Okayama Medical and Dental Practitioner's Association were surveyed. The nine-page, 27-item questionnaire covered dentist job satisfaction, physical practice, and dentist and patient characteristics. Respondents to the first mailing or the one-week follow-up postcard were defined as early responders; others who responded were late responders. Responder bias was assessed by examining age, gender and training. RESULTS: The overall response rate was 46.7% (223/478). The response rates by follow-up mailing were, 18% after the first mailing, 35.4% after the follow-up postcard, 42.3% after the second mailing, and 46.7% after the third mailing. Respondents did not differ from non-respondents in age or gender, nor were there differences between early and late responders. CONCLUSION: The application of TDM in this survey of Japanese dentists produced lower rates of response than expected from previous Japanese and US studies

Evaluation of Multidrug Efflux Pump Inhibitors by a New Method Using Microfluidic Channels

Fluorescein-di-β-d-galactopyranoside (FDG), a fluorogenic compound, is hydrolyzed by β-galactosidase in the cytoplasm of Escherichia coli to produce a fluorescent dye, fluorescein. We found that both FDG and fluorescein were substrates of efflux pumps, and have developed a new method to evaluate efflux-inhibitory activities in E. coli using FDG and a microfluidic channel device. We used E. coli MG1655 wild-type, ΔacrB (ΔB), ΔtolC (ΔC) and ΔacrBΔtolC (ΔBC) harboring plasmids carrying the mexAB-oprM (pABM) or mexXY-oprM (pXYM) genes of Pseudomonas aeruginosa. Two inhibitors, MexB-specific pyridopyrimidine (D13-9001) and non-specific Phe-Arg-β-naphthylamide (PAβN) were evaluated. The effects of inhibitors on pumps were observed using the microfluidic channel device under a fluorescence microscope. AcrAB-TolC and analogous pumps effectively prevented FDG influx in wild-type cells, resulting in no fluorescence. In contrast, ΔB or ΔC easily imported and hydrolyzed FDG to fluorescein, which was exported by residual pumps in ΔB. Consequently, fluorescent medium in ΔB and fluorescent cells of ΔC and ΔBC were observed in the microfluidic channels. D13-9001 substantially increased fluorescent cell number in ΔBC/pABM but not in ΔBC/pXYM. PAβN increased medium fluorescence in all strains, especially in the pump deletion mutants, and caused fluorescein accumulation to disappear in ΔC. The checkerboard method revealed that D13-9001 acts synergistically with aztreonam, ciprofloxacin, and erythromycin only against the MexAB-OprM producer (ΔBC/pABM), and PAβN acts synergistically, especially with erythromycin, in all strains including the pump deletion mutants. The results obtained from PAβN were similar to the results from membrane permeabilizer, polymyxin B or polymyxin B nonapeptide by concentration. The new method clarified that D13-9001 specifically inhibited MexAB-OprM in contrast to PAβN, which appeared to be a substrate of the pumps and permeabilized the membranes in E. coli

A Rapid Microassay for Dichloroacetate in Serum by Gel-Permeation Chromatography

Peer Reviewe

Theories with limited extrinsic curvature and a nonsingular anisotropic universe

We propose a class of theories that can limit scalars constructed from the extrinsic curvature. Applied to cosmology, this framework allows us to control not only the Hubble parameter but also anisotropies without the problem of Ostrogradsky ghost, which is in sharp contrast to the case of limiting spacetime curvature scalars. Our theory can be viewed as a generalization of mimetic and cuscuton theories (thus clarifying their relation), which are known to possess a structure that limits only the Hubble parameter on homogeneous and isotropic backgrounds. As an application of our framework, we construct a model where both anisotropies and the Hubble parameter are kept finite at any stage in the evolution of the universe in the diagonal Bianchi type I setup. The universe starts from a constant-anisotropy phase and recovers Einstein gravity at low energies. We also show that the cosmological solution is stable against essentially all modes of perturbation, provided some reasonable conditions are satisfied