ショウニ ノ ショクモツ アレルギー ノ ジッタイ ト ショクセイカツ

Allergies rarely developed in Japan immediately after the Second World War, but have been remarkablely increased in the current two decades with the change of the life and dietary habits as like western. To date, it is deduced that recent progressive increase of allergic diseases in Japan may be caused by multi-factors rather than one major factor on the basis of the current life and dietary habits. The disadvantage reaction caused by taking food is called “adverse reaction to food”, which is divided into two categories ; one is food allergy caused by immunological reactions and the other is food intolerance caused by enzyme effects, pharmacological effects, or toxic properties. Food allergy causes in some persons, especially in infants, by eating food most of foods have possibility to cause allergy. In infants hen’s egg and cow’s milk are frequently identified as major food allergens. These foods are well inducible for toleration as they grow. On the contray, soba and peanuts that are known as food allergens but cause sometimes systemic anaphylaxis without toleration against them. The gold standard for preventing allergic symptoms in patients with food allergy is the elimination of the identified foods as allergens from diets. It is not only safe therapy but also prevents the development of other types of allergy

ナゼ アレルギー シッカン ワ ゾウカ シテ イルノカ : エイヨウガク ノ タチバ ヨリ

Allergy, in the form of atopic diseases such as atopic eczema, allergic rhinitis, and asthma, is a chronic disorder of increasing importance in the developed countries. Although several environmental exposures, including dietary factors, infection, and microflora, have been implicated in the cause of allergic diseases, these relationship remains unclear. In respect to dietary factor, one of the candidates that contribute to the disease is polyunsaturated fatty acid because many reports showed that n-3 fatty acids have property to suppress the inflammatory immune response. Therefore, it is possible that intake of fatty acids at unsuitable n-3/n-6 ratio causes the allergic disease. Other than fatty acid, it has shown that higher concentrations of vitamin E intake are associated with lower serum IgE concentration and a lower frequency of allergen sensitization

Fluorescence diagnosis of metastatic lymph nodes using 5-aminolevulinic acid (5-ALA) in a mouse model of colon cancer.

[Background]Lymph node metastasis is one of the most critical prognostic factors in patients with colorectal cancer. Although regional lymph nodes should be surgically resected and pathologically examined, techniques for the intraoperative diagnosis of lymph node metastasis remain to be well established. Fluorescence diagnosis using 5-aminolevulinic acid (5-ALA) is a promising technique for evaluating various malignancies. After exogenous administration of 5-ALA, protoporphyrin IX (PPIX) accumulates in malignant cells and can be detected as red fluorescence. In this study, we investigated the usefulness of fluorescence diagnosis using 5-ALA for the detection of lymph node metastasis in a mouse model of colon cancer. [Materials and Methods]An orthotopic colon cancer model was prepared by inoculating the cecal wall of nude mice with HCA7, a human colon adenocarcinoma cell line. After 3 wk, 40 mg/kg of 5-ALA was administered intraperitoneally (IP) or orally (PO). Fluorescence diagnosis with a D-Light System (Karl Storz) was then performed after 3 or 6 h. [Results]In the IP group, PPIX fluorescence was detected in metastatic lymph nodes as well as in other malignant lesions, including primary tumors and abdominal implantations, while non-metastatic nodes were fluorescence-negative. In contrast, no obvious fluorescence was detected in cancerous tissues in the PO group. [Conclusions]PPIX fluorescence induced by intraperitoneal injection of 5-ALA allows metastatic lymph nodes to be accurately diagnosed in this mouse model. This technique may facilitate the intraoperative diagnosis of lymph node metastases from colon cancer in a clinical setting

野球ボールの衝撃力と変形挙動の解析

金沢大学工学

A retrieval support system by suggesting terms to a user

Abstract We propose a support method for information retrieva

Prevalence and risk factors for low back pain among professional cooks working in school lunch services

<p>Abstract</p> <p>Background</p> <p>The prevalence of self-reported low back pain among professional cooks was estimated to examine the effects of daily life conditions, job-related factors, and psychological factors on this disorder.</p> <p>Methods</p> <p>Data was collected using a mailed self-administered questionnaire.</p> <p>Results</p> <p>Of 7100 cooks, 5835 (82%) replied to the questionnaire, including 1010 men and 4825 women. The mean age was 41.4 for men and 47.5 for women. The prevalence of low back pain during a 1-month period was 72.2% among men and 74.7% among women, with no significant differences between groups. By logistic regression analyses, factors significantly associated with the prevalence of low back pain in 1 month were female gender (prevalence ratio [PR] 1.32; 95% CI, 1.03–1.68), current smoking (PR 1.57; 95% CI, 1.24–1.98), and past smoking (PR 1.35; 95% CI, 1.01–1.79). As for job-related factors, the number of cooked lunches per person (PR 1.28; 95% CI, 1.05–1.56), breaks in the morning session (PR 1.33; 95% CI, 1.13–1.56), kitchen environment (PR 1.09; 95%, CI, 1.03–1.15), and height of cooking equipment (PR 1.13; 95% CI, 1.08–1.19) were associated with the prevalence of low back pain. As for psychological factors, job satisfaction (PR 1.22; 95% CI, 1.03–1.45), stress at work (PR 1.68; 95% CI, 1.42–1.99), financial constraints (PR 1.23; 95% CI, 1.03–1.47), health-related stress (PR 1.31; 95% CI, 1.08–1.59) and worries about the future (PR 1.24; 95% CI, 1.01–1.52) were similarly associated.</p> <p>Conclusion</p> <p>Daily life conditions, job-related factors, and psychological factors are associated with the occurrence of low back pain. It is important to take comprehensive preventive measures to address a range of work and life conditions that can be improved to decrease the incidence of low back pain for professional cooks.</p

Isolation of Novel Adenovirus from Fruit Bat (Pteropus dasymallus yayeyamae)

Isolation of Novel Adenovirus from Fruit Ba

A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain

<p>Abstract</p> <p>Background</p> <p>Local anesthetics alleviate neuropathic pain in some cases in clinical practice, and exhibit longer durations of action than those predicted on the basis of the pharmacokinetics of their blocking effects on voltage-dependent sodium channels. Therefore, local anesthetics may contribute to additional mechanisms for reversal of the sensitization of nociceptive pathways that occurs in the neuropathic pain state. In recent years, spinal glial cells, microglia and astrocytes, have been shown to play critical roles in neuropathic pain, but their participation in the analgesic effects of local anesthetics remains largely unknown.</p> <p>Results</p> <p>Repetitive epidural administration of ropivacaine reduced the hyperalgesia induced by chronic constrictive injury of the sciatic nerve. Concomitantly with this analgesia, ropivacaine suppressed the increases in the immunoreactivities of CD11b and glial fibrillary acidic protein in the dorsal spinal cord, as markers of activated microglia and astrocytes, respectively. In addition, epidural administration of a TrkA-IgG fusion protein that blocks the action of nerve growth factor (NGF), which was upregulated by ropivacaine in the dorsal root ganglion, prevented the inhibitory effect of ropivacaine on microglia, but not astrocytes. The blockade of NGF action also abolished the analgesic effect of ropivacaine on neuropathic pain.</p> <p>Conclusions</p> <p>Ropivacaine provides prolonged analgesia possibly by suppressing microglial activation in an NGF-dependent manner and astrocyte activation in an NGF-independent manner in the dorsal spinal cord. Local anesthetics, including ropivacaine, may represent a new approach for glial cell inhibition and, therefore, therapeutic strategies for neuropathic pain.</p