Indigo plant improves serum lipid profiles

We investigated the effects of Polygonum tinctorium Lour (PTL), a plant commonly known as indigo, on biological parameters in an animal model of high-fat diet-induced obesity. Wistar rats fed a high-fat diet and treated with PTL showed lower serum levels of triglycerides and total cholesterol levels and a higher serum levels of HDL cholesterol than those in Wistar rats fed a high-fat diet without PTL treatment. The weight of mesenteric fat in PTL-treated rats was decreased compared to that in control rats not treated with PTL. In addition, energy metabolic rate in the dark period, but not in the light period, in PTL-treated rats was higher than that in control rats. Although a significant difference was not observed, body weight in PTL-treated rats tended to be decreased compared to that in control rats. The results show that PTL improves serum lipid profiles in Wistar rats with high-fat diet-induced obesity

Nonlinear dynamics of ship capsizing at sea

Capsizing is one of the worst scenarios in oceangoing vessels. It could lead to a high number of fatalities. A considerable number of studies have been conducted until the 1980s, and one of the discoveries is the weather criterion established by the International Maritime Organization (IMO). In the past, one of the biggest difficulties in revealing the behavior of ship-roll motion was the nonlinearity of the governing equation. On the other hand, after the mid-1980s, the complexity of the capsizing problem was uncovered with the aid of computers. In this study, we present the theoretical backgrounds of the capsizing problem from the viewpoint of nonlinear dynamics. Then, we discuss the theoretical conditions and mechanisms of the bifurcations of periodic solutions and numerical attempts for the bifurcations and capsizing

On the loss of stability of periodic oscillations and its relevance to ship capsize

This research revisits the analysis of roll motion and the possible capsize of floating vessels in beam seas. Many analytical investigations of this topic have adopted the softening Duffing equation, which is similar to the ship roll equation of motion. Here we focus on the loss of stability of periodic oscillations and its relevance to ship capsize. Previous researchers have found the thresholds of the saddle-node, flip, and heteroclinic bifurcations. They derived the flip condition from the negative stiffness condition in a Mathieu-type variational equation. In our revisited analysis, we show that this threshold is identical to a pitchfork bifurcation. On the other hand, we simultaneously find that the generated asymmetry solution is unstable due to the limitation of the first order analysis

Chronological Progression of an Enlarged Styloid Process: A Case Report of Eagle Syndrome

Eagle syndrome is characterized by an elongated styloid process. However, the time frame over which the styloid process becomes elongated and extends is unknown. How the condition worsens over time is also unclear. To date, there has been no report describing the chronologic change that occurs in the styloid process in Eagle syndrome. We describe a 53-year-old patient with Eagle syndrome in whom the styloid process enlarged progressively over time and the elongated styloid process fused with the hyoid bone. The styloid process was resected via a transcervical approach, and the patient’s subjective symptoms improved. This is the first report showing how the styloid process can enlarge over a few years in a patient with Eagle syndrome. Surgical resection via a transcervical approach is an appropriate treatment for a patient in whom the styloid process has become excessively enlarged and elongated

Superconductivity and the Effects of Pressure and Structure in Single Crystalline SrNi2_2P2_2

Heat capacity, magnetic susceptibility, NMR, and resistivity of SrNi2P2 single crystals are presented, illustrating a purely structural transition at 325 K with no magnetism. Bulk superconductivity is found at 1.4 K. The magnitude of the transition temperature T_c, fits to the heat capacity data, the small upper critical field $H_{c2}$ = 390 Oe, and Ginzburg-Landau parameter $\kappa$ = 2.1 suggests a conventional fully gapped superconductor. With applied pressure a second structural phase transition occurs which results in an 8% reduction in the c/a ratio of lattice parameters. We find that superconductivity persists into this high pressure phase, although the transition temperature is monotonically suppressed with increasing pressure. Comparison of these Ni-P data as well as layered Fe-As and Ni-As superconductor indicates that reduced dimensionality can be a mechanism for increasing the transition temperature.Comment: 6 pages, 7 figures, New Title, minor changes, published in PRB as an editor's suggestio

Fibroblasts Show More Potential as Target Cells than Keratinocytes in COL7A1 Gene Therapy of Dystrophic Epidermolysis Bullosa

Dystrophic epidermolysis bullosa (DEB) is an inherited blistering skin disorder caused by mutations in the type VII collagen gene (COL7A1). Therapeutic introduction of COL7A1 into skin cells holds significant promise for the treatment of DEB. The purpose of this study was to establish an efficient retroviral transfer method for COL7A1 into DEB epidermal keratinocytes and dermal fibroblasts, and to determine which gene-transferred cells can most efficiently express collagen VII in the skin. We demonstrated that gene transfer using a combination of G protein of vesicular stomatitis virus-pseudotyped retroviral vector and retronectin introduced COL7A1 into keratinocytes and fibroblasts from a DEB patient with the lack of COL7A1 expression. Real-time polymerase chain reaction analysis of the normal human skin demonstrated that the quantity of COL7A1 expression in the epidermis was significantly higher than that in the dermis. Subsequently, we have produced skin grafts with the gene-transferred or untreated DEB keratinocytes and fibroblasts, and have transplanted them into nude rats. Interestingly, the series of skin graft experiments showed that the gene-transferred fibroblasts supplied higher amount of collagen VII to the new dermal–epidermal junction than the gene-transferred keratinocytes. An ultrastructural study revealed that collagen VII from gene-transferred cells formed proper anchoring fibrils. These results suggest that fibroblasts may be a better gene therapy target of DEB treatment than keratinocytes

General Formulation for Proton Decay Rate in Minimal Supersymmetric SO(10) GUT

We make an explicit formulation for the proton decay rate in the minimal renormalizable supersymmetric (SUSY) SO(10) model. In this model, the Higgs fields consist of ${\bf 10}$ and ${\bf \bar{126}}$ SO(10) representations in the Yukawa interactions with matter and of ${\bf 10}$, ${\bf \bar{126}}$, ${\bf 126}$, and ${\bf 210}$ representations in the Higgs potential. We present all the mass matrices for the Higgs fields contained in this minimal SUSY SO(10) model. Finally, we discuss the threshold effects of these Higgs fields on the gauge coupling unification.Comment: 32 pages, typos are corrected, a few references and comments to the papers arXiv:hep-ph/0204097 and arXiv:hep-ph/0402122 are adde

First-in-human phase 1 trial of hemoglobin vesicles as artificial red blood cells developed for use as a transfusion alternative

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Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities

Intracellular polysulfide could regulate the redox balance via its anti-oxidant activity. However, the existence of polysulfide in biological fluids still remains unknown. Recently, we developed a quantitative analytical method for polysulfide and discovered that polysulfide exists in plasma and responds to oxidative stress. In this study, we confirmed the presence of polysulfide in other biological fluids, such as semen and nasal discharge. The levels of polysulfide in these biological fluids from healthy volunteers (n = 9) with identical characteristics were compared. Additionally, the circadian rhythm of plasma polysulfide was also investigated. The polysulfide levels detected from nasal discharge and seminal fluid were approximately 400 and 600 μM, respectively. No correlation could be found between plasma polysulfide and the polysulfide levels of tear, saliva, and nasal discharge. On the other hand, seminal polysulfide was positively correlated with plasma polysulfide, and almost all polysulfide contained in semen was found in seminal fluid. Intriguingly, saliva and seminal polysulfide strongly correlated with salivary amylase and sperm activities, respectively. These results provide a foundation for scientific breakthroughs in various research areas like infertility and the digestive system process