35 research outputs found
Versatile roles of brassinosteroid in plants in the context of its homoeostasis, signaling and crosstalks
Brassinosteroids are a class of steroidal plant hormones that play diverse roles in plant growth and developmental processes. Recently, the easy availability of biological resources, and development of new molecular tools and approaches have provided the required impetus for deeper understanding of the processes involved in brassinosteroids biosynthesis, transport, signaling and degradation pathways. From recent studies it is also evident that brassinosteroids interact with other phytohormones such as auxin, cytokinin, ethylene, gibberellin, jasmonic acid, abscisic acid, salicylic acid and polyamine in regulating wide range of physiological and developmental processes in plants. The inputs from these studies are now being linked to the versatile roles of brassinosteroids. The present review highlights the conceptual development with regard to BR homeostasis, signaling and its crosstalk with other phytohormones. This information will assist in developing predictive models to modulate various useful traits in plants and address current challenges in agriculture
Results of sagittaly unstable intertrochanteric fractures managed by dual reduction technique
Background: We evaluated the functional and radiological outcome of sagittally unstable intertrochanteric fractures reduced by dual technique consisting of a crutch placed posteriorly over distal fragment and pushing the flexed proximal fragment by ramrod anteriorly over a period of 12 months.Methods: A fracture was defined as sagittally unstable intertrochanteric fracture when posterior sagging of distal fragment and flexion of proximal fragment worsens after routine maneuvers for closed reduction. Out of the 80 intertrochanteric fractures treated from February 2018 to April 2019, 16 hips had sagittal instability and after reduction were treated with proximal femoral nail (Stryker Trauson) in some patients and DePuy Synthes proximal femoral nail PFNA in remaining patients. These 16 patients were followed up for a period of 1 year and functional and radiological outcome was noted.Results: Out of the 16 patients, 10 were males and 6 were females. The mean age was 68.2 years. According to the A.O classification out of the 16 patients, 7, 5 and 4 patients were classified as A1.3, A2.1, and A2.2 or more. The mean time from injury till surgery was 4.6 days. The mean surgical time was 45.8 minutes. The mean time for radiological union was 22.4 weeks. The mean pre injury activity level was 4.2 while the mean final activity level was 3.8 (1-5) according to modified Koval activity index.Conclusions: Anatomical reduction followed by rigid internal fixation is the key to success in intertrochanteric fractures.
Angiomatous nasal polyp: Clinical diagnostic dilemma
Angiomatous polyp (Angiectatic nasal polyps) is rare and its incidence is 4-5% of all nasal polyps. As it occurs with variable clinical features and there is no confirmatory preoperative investigation, clinical diagnosis can be a dilemma. Clinical picture of angiofibroma, simple antrochoanal polyp and inverted papilloma may resemble with each other. As polyps invade surrounding bone, these should be distinguished from a malignant mass. We present an interesting case of an infarcted angiectatic nasal polyp with extensive surrounding bony destruction. Correct preoperative radiological diagnosis is important to avoid unnecessary extensive surgery. Histopathological evaluation of polyps is mandatory since they require different treatment due to difference in the prognosis
Role of once-daily tadalafil in men with concomitant erectile dysfunction and symptomatic benign prostatic hyperplasia: A prospective randomized placebo-controlled study
Background: Majority of men over age 50 are sexually active and sex is an important part of overall quality of life. Both benign prostatic hyperplasia (BPH) with lower urinary tract symptoms-BPH (BPH-LUTS) and erectile dysfunction (ED) are often found in this age group simultaneously. Pathophysiological mechanisms for both these diseases are almost common. All males presenting with LUTS should be assessed for sexual dysfunction and viceversa. The aim of this study is to evaluate the effects of once-daily tadalafil on erectile function in men with ED and benign prostatic hypertrophy with LUTS. One drug for treatment of both diseases and better patient′s compliance are important issues for proper management.
Materials and Methods: We did a study of 60 men. All patients were divided in two groups: 30 in group A who were given tadalafil 5 mg (megalis-5 mg of Macleods Pharmaceutical Company) and 30 patients in group B who were on placebo (plain sugar pills) for 12-week. This was a randomized, placebo-controlled study of once-daily tadalafil, which was carried out in men with BPH-LUTS in a rural Medical College of Northern India during June 2009 to November 2011.
Results: International index of erectile function-erectile function (IIEF-EF) domain score improvements from baseline with 5 mg once-daily tadalafil were significantly greater throughout the study for tadalafil groups versus placebo (all P ≤ 0.001). International Prostate Symptom Score (IPSS) improvements from baseline to end point were significantly greater with 5 mg tadalafil dose versus placebo (all P < 0.05).
Conclusion: There are encouraging results with tadalafil. It was used in 30 patients who were suffering with both ailments of BPH and LUTS simultaneously and is effective in both diseases
Angiomatous nasal polyp: Clinical diagnostic dilemma
Angiomatous polyp (Angiectatic nasal polyps) is rare and its incidence is 4-5% of all nasal polyps. As it occurs with variable clinical features and there is no confirmatory preoperative investigation, clinical diagnosis can be a dilemma. Clinical picture of angiofibroma, simple antrochoanal polyp and inverted papilloma may resemble with each other. As polyps invade surrounding bone, these should be distinguished from a malignant mass. We present an interesting case of an infarcted angiectatic nasal polyp with extensive surrounding bony destruction. Correct preoperative radiological diagnosis is important to avoid unnecessary extensive surgery. Histopathological evaluation of polyps is mandatory since they require different treatment due to difference in the prognosis.</p
Tailoring MOF-5 Photocatalysts: Low-Temperature Synthesis and Solvent Variations for Enhanced Performance in Dye Degradation
Metal-organic frameworks (MOFs) are emerging as pivotal porous crystalline materials with diverse applications. Typically, MOFs are synthesized using solvothermal techniques at high temperatures and pressures. In this study, a novel approach was employed to synthesize zinc-based MOFs, specifically MOF-5, at low temperatures (up to 50 °C) via chemical mixing at standard pressures. Varying the temperature and solvents, N-methyl-2-pyrrolidone (NMP) and N,N-dimethylformamide (DMF), in the chemical mixing process, the highest yield of the material was observed with DMF at 50 °C (M1). Two additional samples, M2 and M3, are synthesized at room temperature using DMF and NMP, respectively. Despite similarities in XRD, Raman, and FTIR analyses confirming successful MOF-5 formation, noticeable differences in sample morphology arise due to distinct synthesis conditions, particularly solvent and temperature variations. The MOF-5 samples exhibit UV absorption with varying band gaps. Notably, when employed as photocatalysts for organic dye (methylene blue) degradation, M2 outperforms others, achieving an impressive 85% degradation under simulated solar light irradiation. This work underscores the significance of tuning MOF photocatalyst properties through tailored synthesis routes, recognizing the profound impact of morphology and elemental composition on enhancing photocatalytic dye degradation performance. Copyright © 2024 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Corrigendum: Microsized-titanium dioxide based self-cleaning cement: incorporation of calcined dolomite for enhancement of photocatalytic activity (2018 Mater. Res. Express 5 115509)
Laparoscopic cholecystectomy in situs inversus totalis: A review article
Background: Situs inversus totalis is a rare congenital anomaly characterized by transposition of organs to the opposite side of the body. Diagnosis and treatment of cholelithiasis in such cases pose a challenge to the operating surgeon because of an atypical clinical picture and the contra lateral disposition of the viscera.
Methods: A literature search using the PubMed and Cochrane databases identified articles focusing on the key issues of laparoscopy cholecystectomy in situs inversus.
Conclusions: Without doubt, laparoscopic cholecystectomy in these patients is technically more demanding but still feasible and should be performed by trained and experienced laparoscopic surgeons. Difficulty is encountered in skeletonizing the structures in Calot's triangle, which usually requires extra time than in patients with a normally located gall bladder. [Arch Clin Exp Surg 2016; 5(3.000): 169-176