Contributions to the study of the relations between episodic memory and Theory of Mind

El presente trabajo indaga las relaciones entre los procesos cognitivos y afectivos de la teoría de la mente y la memoria episódica verbal en mujeres con diagnóstico de Síndrome de Turner. Trastorno cromosómico cuya expresión origina una morfología cerebral atípica que afecta zonas frontales y temporoparietales, coincidentes con el sustrato neuroanatómico compartido por la teoría de la mente y la memoria episódica. La teoría de la mente emerge en el desarrollo con anterioridad a la memoria episódica, posibilitando a través de la capacidad de metarrepresentación el desdoblamiento y viaje mental que la misma implica. Para la evaluación de los procesos se administraron las Historias Extrañas de Happé, el Test de las miradas, el Test de Aprendizaje Verbal España-Complutense y una tarea experimental a 20 mujeres con diagnóstico de Síndrome de Turner y sus respectivos controles. Los resultados indican dificultades en ambos procesos cognitivos y correlaciones entre la teoría de la mente e indicadores de memoria episódica de contenido y de la fuente. Se hipotetiza que la anatomía cerebral atípica, propia de esta población, traería problemas en el desarrollo de la teoría de la mente y esto, a su vez, podría asociarse con dificultades en los mecanismos de metarrepresentación y re-experimentación subjetiva de vivencias que la memoria episódica implica. Los resultados obtenidos permiten una mayor comprensión del perfil neuropsicológico de las mujeres con diagnóstico de Síndrome de Turner y podrían servir de insumo teórico para el diseño de estrategias clínicas y psicoeducativas que tiendan a fomentar, en esta población, las habilidades de teoría de la mente y memoria episódica.The present study explores the relations between the cognitive and affective processes of theory of mind and verbal episodic memory in women diagnosed with Turner Syndrome, a chromosomal disorder caused by a missing or incomplete X chromosome in females. Women with this diagnostic present an typical cerebral morphology affecting frontal and temporoparietal zones. These areas match the neuroanatomic substratum shared by both theory of mind and episodic memory. The concept of theory of mind refers to the ability to anticipate others’ social behavior through the attribution and understanding of mental entities such as desires, beliefs, emotions and intentions. It is a complex skill that involves not only the mental representation of something that cannot be observed directly, but also the decentration of one’s own perspective and the use of these skills to predict behaviors. This ability is composed by two different processes: a cognitive theory of mind that refers to the ability to make inferences about desires, beliefs and intentions of other people; and an affective theory of mind, related to the ability to infer others’ emotions, understanding the affective mental states and adopting the point of view of the other person, without experiencing these emotions. In the particular case of women diagnosed with Turner Syndrome, there is evidence supporting the hypothesis that this population presents general difficulties in this ability, showing a greater deficit in cognitive theory of mind. On the other hand, episodic memory consists of the memory that one has of past experiences. This memory system is a psychological process of paramount importance for human beings, since it enables the remembrance of something that has happened a long time ago. It allows the person to re-experience events that occurred earlier in his or her life, involving the ability to generate meta-representational comments on how knowledge was obtained. This way, people revive, through self-awareness, previous experiences and also project similar experiences to the future. Episodic memory can be divided into the memory about the occurrence of an event (item memory) and the memory of the phenomenological context of the event, which involves the handling of spatial, temporal, emotional and perceptual information (source memory). It is considered that theory of mind has an earlier development than episodic memory, enabling through the capacity of meta-representation the unfolding and mental journey that episodic memory implies. In order to evaluate these processes, a battery of four tests was administered to 20 women diagnosed with Turner Syndrome and their respective controls: Happé Strange Stories, the Reading the Mind in the Eyes Test, the Spain-Complutense Verbal Learning Test and an experimental task. Results indicate difficulties in both cognitive processes, as well as correlations between theory of mind and indicators of item and source memory. A possible hypothesis could argue that the atypical cerebral anatomy of women diagnosed with Turner Syndrome would result in theory of mind deficits, and these in turn could be associated with difficulties in the capacities of meta-representation and subjective re-experimentation of past events needed by episodic memory. These results enable a better comprehension of the neuropsychological profile of women diagnosed with Turner Syndrome and could serve as a theoretical input for the design of clinical and psychoeducational strategies that tend to promote theory of mind and episodic memory in this population.Fil: Aguilar, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología.; ArgentinaFil: Agula, Lucía. Universidad Nacional de Mar del Plata; ArgentinaFil: Said, Andrea Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología.; ArgentinaFil: López, Marcela Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología.; Argentin

Relationship between growth hormone treatment and personality profiles in women diagnosed with Turner Syndrome

El objetivo del presente trabajo fue identificar la existencia de perfiles distintivos en las escalas de personalidad en relación con la aplicación o no de hormona de crecimiento en 73 mujeres adultas con diagnóstico de Síndrome de Turner de Latinoamérica. Para ello se administró, en formato online, el Inventario Clínico Multiaxial de Millon II y un cuestionario clínico para recabar datos sobre la realización o no de tratamiento con hormona de crecimiento durante el desarrollo con el fin de comparar ambos grupos. Los resultados encontrados muestran que el grupo que no realizó tratamiento con hormona de crecimiento obtiene medias más altas en casi la totalidad de las escalas de personalidad básicas y patológicas en comparación con el grupo que sí realizó tratamiento, siendo dicha diferencia significativa en la escala esquizotípica. Esta escala se asocia con necesidades afectivas mínimas, aislamiento social y apego empobrecido. Estos resultados podrían dar cuenta que el tratamiento con hormona de crecimiento sería un factor positivo para esta población, favoreciendo el desarrollo de características de personalidad más adaptativas en relación a lo social.The aim of this study was to identify the existence of distinctive profiles on the personality scales in relation to the application or not of the growth hormone in 73 adult women diagnosed with Turner Syndrome in Latin America. For it was administered, in online form, the Millon Clinical Multiaxial Inventory II and a clinical questionnaire to collect data on the realization or non-treatment with growth hormone during development in order to compare both groups. The results show that the group did not make growth hormone treatment gets highest averages in nearly all of the basic and pathological personality scales compared to the group that if he completed treatment, being such significant difference in schizotypal scale. This scale is associated with minimal emotional needs, social isolation and impoverished attachment. These results might note that treatment with growth hormone could be a positive factor for this population, favoring the development of more adaptive personality characteristics in relation to the social aspects.Fil: Sartori, Maria Soledad. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología; ArgentinaFil: López, Marcela Carolina. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología; ArgentinaFil: Hermida, Mariana. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología; ArgentinaFil: Said, Andrea Giselle. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología; Argentin

Maltrato infantil por negligencia: salud mental y riesgo psicosocial en madres con expedientes legales

A study with a descriptive qualitative approach is presented, supported by quantitative data that aimed to characterize the mental health status and psychosocial risk factors in a group of mothers with child abuse records due to neglect. The sample consisted of 5 women who, between the years 2019 and 2020, had open legal proceedings in the five family police stations of the municipality of Rionegro (Antioquia, Colombia) for alleged threat, violation or non-observance of their children's rights. The findings show that these mothers present symptoms of depression, severe anxiety and low satisfaction with life; in addition to precarious socioeconomic conditions and low availability of support networks. It is concluded that mental health is a fundamental condition for the exercise of respectful parenting.Se presenta un estudio con enfoque cualitativo del nivel descriptivo, con apoyo de datos cuantitativos, que tuvo por objetivo caracterizar el estado de salud mental y factores de riesgo psicosocial en un grupo de madres con expedientes de maltrato infantil por negligencia. La muestra estuvo conformada por 5 mujeres que, entre los años 2019 y 2020, tuvieron abiertos procesos legales en las cinco comisarías de familia del municipio de Rionegro (Antioquia, Colombia) por presunta amenaza, vulneración o inobservancia de los derechos de sus hijos. Los hallazgos muestran que estas madres presentan síntomas de depresión, ansiedad severa y baja satisfacción con la vida, además de precarias condiciones socioeconómicas y poca disponibilidad de redes de apoyo. Se concluye que la salud mental es una condición fundamental para el ejercicio de una crianza respetuosa

Contributions to the study of the relations between episodic memory and Theory of Mind

El presente trabajo indaga las relaciones entre los procesos cognitivos y afectivos de la teoría de la mente y la memoria episódica verbal en mujeres con diagnóstico de Síndrome de Turner. Trastorno cromosómico cuya expresión origina una morfología cerebral atípica que afecta zonas frontales y temporoparietales, coincidentes con el sustrato neuroanatómico compartido por la teoría de la mente y la memoria episódica. La teoría de la mente emerge en el desarrollo con anterioridad a la memoria episódica, posibilitando a través de la capacidad de metarrepresentación el desdoblamiento y viaje mental que la misma implica. Para la evaluación de los procesos se administraron las Historias Extrañas de Happé, el Test de las miradas, el Test de Aprendizaje Verbal España-Complutense y una tarea experimental a 20 mujeres con diagnóstico de Síndrome de Turner y sus respectivos controles. Los resultados indican dificultades en ambos procesos cognitivos y correlaciones entre la teoría de la mente e indicadores de memoria episódica de contenido y de la fuente. Se hipotetiza que la anatomía cerebral atípica, propia de esta población, traería problemas en el desarrollo de la teoría de la mente y esto, a su vez, podría asociarse con dificultades en los mecanismos de metarrepresentación y re-experimentación subjetiva de vivencias que la memoria episódica implica. Los resultados obtenidos permiten una mayor comprensión del perfil neuropsicológico de las mujeres con diagnóstico de Síndrome de Turner y podrían servir de insumo teórico para el diseño de estrategias clínicas y psicoeducativas que tiendan a fomentar, en esta población, las habilidades de teoría de la mente y memoria episódica.The present study explores the relations between the cognitive and affective processes of theory of mind and verbal episodic memory in women diagnosed with Turner Syndrome, a chromosomal disorder caused by a missing or incomplete X chromosome in females. Women with this diagnostic present an typical cerebral morphology affecting frontal and temporoparietal zones. These areas match the neuroanatomic substratum shared by both theory of mind and episodic memory. The concept of theory of mind refers to the ability to anticipate others’ social behavior through the attribution and understanding of mental entities such as desires, beliefs, emotions and intentions. It is a complex skill that involves not only the mental representation of something that cannot be observed directly, but also the decentration of one’s own perspective and the use of these skills to predict behaviors. This ability is composed by two different processes: a cognitive theory of mind that refers to the ability to make inferences about desires, beliefs and intentions of other people; and an affective theory of mind, related to the ability to infer others’ emotions, understanding the affective mental states and adopting the point of view of the other person, without experiencing these emotions. In the particular case of women diagnosed with Turner Syndrome, there is evidence supporting the hypothesis that this population presents general difficulties in this ability, showing a greater deficit in cognitive theory of mind. On the other hand, episodic memory consists of the memory that one has of past experiences. This memory system is a psychological process of paramount importance for human beings, since it enables the remembrance of something that has happened a long time ago. It allows the person to re-experience events that occurred earlier in his or her life, involving the ability to generate meta-representational comments on how knowledge was obtained. This way, people revive, through self-awareness, previous experiences and also project similar experiences to the future. Episodic memory can be divided into the memory about the occurrence of an event (item memory) and the memory of the phenomenological context of the event, which involves the handling of spatial, temporal, emotional and perceptual information (source memory). It is considered that theory of mind has an earlier development than episodic memory, enabling through the capacity of meta-representation the unfolding and mental journey that episodic memory implies. In order to evaluate these processes, a battery of four tests was administered to 20 women diagnosed with Turner Syndrome and their respective controls: Happé Strange Stories, the Reading the Mind in the Eyes Test, the Spain-Complutense Verbal Learning Test and an experimental task. Results indicate difficulties in both cognitive processes, as well as correlations between theory of mind and indicators of item and source memory. A possible hypothesis could argue that the atypical cerebral anatomy of women diagnosed with Turner Syndrome would result in theory of mind deficits, and these in turn could be associated with difficulties in the capacities of meta-representation and subjective re-experimentation of past events needed by episodic memory. These results enable a better comprehension of the neuropsychological profile of women diagnosed with Turner Syndrome and could serve as a theoretical input for the design of clinical and psychoeducational strategies that tend to promote theory of mind and episodic memory in this population.Fil: Aguilar, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología.; ArgentinaFil: Agula, Lucía. Universidad Nacional de Mar del Plata; ArgentinaFil: Said, Andrea Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología.; ArgentinaFil: López, Marcela Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Psicología Básica, Aplicada y Tecnología. Universidad Nacional de Mar del Plata. Facultad de Psicología. Instituto de Psicología Básica, Aplicada y Tecnología.; Argentin

Analysis of personality profiles in adult women diagnosed with Turner Syndrome

El Síndrome de Turner es el trastorno cromosómico, no heredable, de mayor incidencia poblacional en el sexo femenino, determinado por la deleción parcial o total del cromosoma X. En el desarrollo de las mujeres con este diagnóstico intervienen factores genéticos, familiares, educacionales y sociales que resultan relevantes en la consolidación de la personalidad. El objetivo del trabajo realizado fue caracterizar la personalidad de mujeres adultas con Síndrome de Turner residentes en Latinoamérica. La muestra fue de tipo no probabilístico intencional y corresponde a 60 mujeres entre 18 y 55 años. Los datos se recabaron a través de una versión virtual del Inventario Clínico Multiaxial de Millon II. Se transformaron las puntuaciones directas en puntuaciones Tasa Base y se obtuvieron estadísticos descriptivos de frecuencias y medidas de tendencia central para caracterizar a las participantes de la muestra. Posteriormente se calculó la razón de momios para obtener el índice de la probabilidad que las mujeres con diagnóstico de Síndrome de Turner presentaran trastornos de la personalidad. Los resultados obtenidos muestran que la probabilidad que presenta dicha población de padecer trastornos de personalidad, en comparación con una muestra clínica normativa, resulta superior para todos los trastornos, siendo las escalas autodestructiva, compulsiva y antisocial aquellas que presentan los porcentajes más altos. Los datos obtenidos dan cuenta de la vulnerabilidad que presenta la población estudiada de padecer trastornos de personalidad y son útiles para el desarrollo de terapias específicas que consideren dichas características en pos de una mejor calidad de vida.Turner Syndrome is a chromosomal, not inher - ited, disorder highest population incidence in females, determined by the partial or complete deletion of chromosome X. Is characterized by short stature and digenesia gonadal and, in a psy - chosocial level, one of the most common traits are the difficulties in establishing interpersonal rela - tion ships. In the development of women with diagnosis of Turner syndrome involves genetic, family, educational and social factors that are relevant in the establishment and consolidation of personality. This last one results from the inter - action between biological and environmental fac tors among which are the inheritance and the learnings. The influence of the personality is a determining factor in the behavior and in the way to adapt to the environment, and may be favorable or pathological depending on the degree of flexibility in the situations of stress. The study of the influence of biological and environmental factors on human development is part of the new contributions of the biopsychosocial paradigm, which seeks to understand the psychological pro - cesses through a comprehensive vision that takes into account the interaction between biological, psychological and social factors in the devel - opment. This interdisciplinary approach oriented perspective becomes more conducive to addressing people with genetic disorders frame, since the differential impact of each of these factors in psychosocial development directly affect their quality of life. The study of personality in people with genetic disorders, and especially in the Turner Syndrome, is currently a vacant area in psychol - ogical research. The aim of the present study was to characterize the personality of adult women with Turner syndrome living in Latin America. The sample was intentional non-probability and corre - sponds to 60 women between 18 and 55 years. The data were gathered through a virtual version of the Millon Multiaxial Clinical Inventory II in the Spanish version. The direct scores transformed on scores Rate-Base and descriptive statistics of frequencies and measures of central tendency were obtained to characterize the sample. Subsequently the odds ratio was calculated to obtain the index of the probability of women with a diagnosis of Turner syndrome present personality disorders. The presence of a personality disorder was con s - idered when the score in the Rate-Base was greater than 84. The results show that the probability that women with a diagnosis of Turner syndrome presents of suffering from personality disorders, in comparison with a clinical normative sample, is higher for all disorders, being antisocial, selfdestructive and compulsive scales those presenting the highest percentages. Thus, despite the limita - tions encountered, it is important to consider that, according to the finding of the scientific literature, personality is partly determined by biological factors, and in this sense the Turner syndrome has a particular specificity to result from loss of genetic material and therefore cause physical and neuro - psychological distinctive characteristics. At the same time, environmental factors would be respon - sible for modular the development of biological predispositions of certain personality traits, and in this sense social relations, the process of social - ization and stimulation that provide girls with a diagnosis of Turner Syndrome from the early years of life, could have a strong impact on the devel - opment of what in future will be formed personality style. The results are important for therapeutic work with women diagnosed with Turner syn - drome because as having empirical information about their characteristics and personality disorders may be possible to diagramming programs specific treatments they consider their particular way of relating to themselves and the environment, seeking to develop new strategies to improve their quality of life. And at the same time, suggests possible interventions at the family level, especially during childhood, aimed at the prevention of de - velopment of dysfunctional personality characteristics.Fil: Sartori, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Psicología. Centro de Investigación en Procesos Básicos, Metodologías y Educación; ArgentinaFil: Urquijo, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Psicología. Centro de Investigación en Procesos Básicos, Metodologías y Educación; ArgentinaFil: López, Marcela Carolina. Universidad Nacional de Mar del Plata. Facultad de Psicología. Centro de Investigación en Procesos Básicos, Metodologías y Educación; ArgentinaFil: Said, Andrea Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Psicología. Centro de Investigación en Procesos Básicos, Metodologías y Educación; ArgentinaFil: Alchieri, Joao Carlos. Universidade Federal do Rio Grande do Norte; Brasi

Evalution through artificial neural networks of the sociodemographic Influences on food choices

Introduction: The EATMOT Project is a multinational study that is being carried out in 16 countries about different eating motivations, given their recognized importance in the definition of people’s dietary patterns. Objective: This study investigated the influence of sociodemographic factors on some types of eating motivations, specifically: health related factors; economic and availability aspects; emotional determinants; social, cultural and religious influences; marketing and advertising campaigns and finally environmental concerns. Methods: This is a longitudinal observational study carried out on a non-probabilistic sample with 11960 participants. For the analysis of the data were used the T-test for independent samples or ANOVA with Post-Hoc Tukey HSD, depending on the case. The modelling through artificial neural networks included 7 input variables (sociodemographic characteristics) and 6 output variables (the eating motivations’ groups). Results: Variables like age, marital status, country, living environment, level of education or professional area significantly influenced all the types of eating motivations analysed. However, regarding gender, no significant differences were observed for two of the six types of motivations analysed: economic & availability and marketing & commercial. The results of the ANN modelling showed that the strongest positive factors determining the eating motivations were age for health, country for emotional motivations, gender for economic & availability, country for social & cultural, country for environmental & political, and finally country also for the marketing & commercial motivations. Conclusions: These results highlight the importance of the sociodemographic characteristics as determinants for eating patterns around the globe, and particularly the geographic location.info:eu-repo/semantics/publishedVersio

Síndrome de Young: Young's Syndrome

Introdução: A Síndrome de Young refere-se à condição rara e hereditária, de etiologia desconhecida, que acomete homens de meia idade causando-lhes a tríade rinossinusite, bronquiectasias e azoospermia obstrutiva. Apresentação do caso: paciente do sexo masculino, 36 anos, encaminhado ao ambulatório de urologia por dificuldade para engravidar. Apresenta tosse crônica e rinossinusite de repetição desde a infância. Exames complementares possibilitaram o diagnóstico de Síndrome de Young. Discussão: A ocorrência de azoospermia persistente com espermatogênese normal, associada a episódios recorrentes de infecções pulmonares, além da exclusão de fibrose cística ou discinesia ciliar primária caracterizam a Síndrome de Young, que não tem cura, contudo é passível a tratamento individualizado e dependente da sintomatologia do paciente. Conclusão: Apesar de ser um distúrbio raro, o diagnóstico precoce é capaz de prevenir complicações associadas, entre elas a infertilidade. No entanto, a escassez de estudos acerca deste distúrbio pode afetar negativamente a qualidade de vida e a morbimortalidade dos pacientes, portanto ressalta-se a importância da produção de evidências científicas

Miradas y voces de la Investigación Educativa III : Formación y desarrollo profesional docente. Innovación Educativa con miras a la justicia social. Aportes desde la Investigación Educativa

Fil: Ferreyra, Horacio Ademar. Universidad Católica de Córdoba. Facultad de Educación; ArgentinaFil: Sañudo Guerra, Lya. Universidad Católica de Córdoba. Facultad de Educación; Argentin

Síndrome de Trotter: Trotter's Syndrome

Introdução: A Síndrome de Trotter refere-se ao quadro clínico característico de neoplasias da nasofaringe, principalmente quando os tumores são encontrados em estágios mais avançados. Apresentação do caso: paciente do sexo masculino, 55 anos, com dor mandibular à esquerda, que iniciou- se com otalgia, zumbido, hipoacusia e cefaléia fronto-temporal à esquerda, evoluindo para dor em região de mandíbula e trismo. Foi solicitado tomografia de base de crânio e nasofaringe, com sinais sugestivos da Síndrome de Trotter. Discussão: O caso trata- se de uma síndrome pouco conhecida devido apresentar sinais e sintomas muitas vezes banalizados, sendo que, a maioria das neoplasias são descobertas em casos bastantes avançados  e com um prognóstico muito reservado. Conclusão: Se descoberta precocemente, aumentaria então, as chances de sucesso no tratamento. Ademais, cabe aos profissionais odontólogos e médicos se atentar e buscar conhecimento acerca da clínica desta síndrome a fim de corroborar no diagnóstico precoce

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo