The Need for New Anti-Hepatitis C Virus Therapeutic Strategies : Targeting the cellular micro-ribonucleic acids?

Infection with the hepatitis C virus (HCV) is a worldwide problem. Patients with chronic HCV infection who are non-responders to standard therapy represent a growing population within the HCV epidemic.Novel, more efficient and tolerable therapies are urgently needed. This review discusses the recent results showing that targeting miR-122, a micro-ribonucleic acid (MicroRNA) that enhances HCV replication, is a new anti-HCV therapy with a high barrier to resistance

On the strong uniform consistency for relative error of the regression function estimator for censoring times series model.

Consider a random vector (X, T), where X is d-dimensional and T is one-dimensional. We suppose that the random variable T is subject to random right censoring and satisfies the α-mixing property. The aim of this paper is to study the behavior of the kernel estimator of the relative error regression and to establish its uniform almost sure consistency with rate. Furthermore, we have highlighted the covariance term which measures the dependency. The simulation study shows that the proposed estimator performs well for a finite sample size in different cases

Seismic Energy Assessment of Buildings with Tuned Vibration Absorbers

Publisher's version (útgefin grein)Seismic analysis and energy assessment of building installed with distributed tuned vibration absorbers (d-TVAs) are presented. The performance of d-TVAs is compared with single tuned vibration absorber (STVA) installed at the top of the building. The placements of the d-TVAs are based on the modal properties of the uncontrolled and controlled buildings. The governing equations of motion of the building with the STVA and d-TVAs are solved by employing Newmark’s integration method. Various energies under earthquake ground excitations are computed to study the effectiveness of using the STVA and d-TVAs. It is concluded that the use of the d-TVAs is the most competent because it effectively dissipates the seismic energy, and they are convenient to install requiring reduced space, as are placed at various floors.Peer Reviewe

Measles on the Rise: The importance of vaccination

non

El uso de la web 2.0 en la comunicación de los profesionales de la Salud en Colombia

This study analyzes the factors that determine the use of webs 2.0 by professionals and students (i.e., residents) in the nursing and medical fields in Colombia when providing health care in the medical centers in which they are employed. Using correlational-explanatory research, this paper conducted interviews of a representative sample of members (n= 424) of the studied population (e=+/- 4.8 and 1-α=0.95).  The obtained data reveal a low level of use of currently available digital resources despite the high level of self-perception of this use and a moderately high assessment of the usefulness of these types of resource while performing professional work. Gender, age, having children, socioeconomic status, training level and the years of experience of the members of the study population significantly affect the use of webs 2.0 social-level resources available today. Improve this use and facilitate a change of attitude for it could simplify meeting their responsibilities within the Colombian health-care system.Tras una década de desarrollo, la aplicación de soluciones de Salud 2.0 ha comenzado a introducirse en Colombia. La investigación analiza cuáles son los factores que determinan el uso de la web 2.0 por parte de profesionales y estudiantes (residentes) del campo de la enfermería y la medicina en Colombia cuando desempeñan la atención sanitaria en los centros médicos donde laboran. Mediante una investigación de carácter correlacional-explicativa, se aplicaron encuestas a una muestra representativa de miembros de la población estudiada con e=+/- 4,8 y 1-α=0,95. Los datos obtenidos permiten apreciar, entre otros alcances, un bajo nivel de aprovechamiento real de los recursos digitales dispuestos en la actualidad, a pesar del alto nivel de auto-percepción sobre dicho aprovechamiento y la valoración medio-alta, sobre la utilidad de este tipo de recursos para el ejercicio de sus labores profesionales. Así mismo, se aprecia cómo el género, la edad, la posesión de hijos, el estrato socioeconómico, el nivel formativo y el tiempo de experiencia de los miembros de la población de estudio inciden significativamente en el nivel de aprovechamiento de recursos web 2.0 disponibles en la actualidad a nivel social que pueden facilitar el ejercicio de su función dentro del sistema de salud colombiano

Functional relative error regression under left truncation and right censoring

The nonparametric estimators built by minimizing the mean squared relative error are gaining in popularity for their robustness in the presence of outliers in comparison to the Nadaraya Watson estimators. In this paper we build a relative error regression function estimator in the case of a functional explanatory variable and a left truncated and right censored scalar variable. The pointwise and uniform convergence of the estimator is proved and its performance is assessed by a numerical study in particularly the robustness which is highlighted using the influence function as a measure of robustness

Seismic Response Mitigation of Base-Isolated Buildings

Earthquake response mitigation of a base-isolated (BI) building equipped with (i) a single tuned mass damper at the top of the building, (ii) multiple tuned mass dampers (MTMDs) at the top of the building, and (iii) MTMDs distributed on different floors of the building (d-MTMDs) is studied. The shear-type buildings are modeled by considering only one lateral degree of freedom (DOF) at the floor level. Numerical approach of Newmark\u27s integration is adopted for solving the coupled, governing differential equations of motion of 5- and 10-story BI buildings with and without TMD schemes. A set of 40 earthquake ground motions, scaled 80 times to get 3200 ground motions, is used to develop simplified fragility curves in terms of the isolator maximum displacement. Incremental dynamic analysis (IDA) is used to develop simplified fragility curves for the maximum target isolator displacement. It is found that TMDs are efficient in reducing the bearing displacement, top floor acceleration, and base shear of the BI buildings. In addition, it was noticed that TMDs are efficient in reducing the probability of failure of BI building. Further, it is found that the MTMDs placed at the top floor and d-MTMDs on different floors of BI buildings are more efficient in decreasing the probability of failure of the BI building when compared with STMD

Transformaciones del mapa comunicacional en la era digital

El objetivo de este informe es exponer los principales resultados obtenidos en el marco del trabajo de investigación elaborado para la obtención del título de doctor por la Universidad Complutense de Madrid, en el que se analizaba el impacto de la convergencia tecnológica en el sector audiovisual, tomando como área de estudio la TV de pago, en la reconfiguración del mapa comunicacional de los espectadores. Para lograr tal objetivo, este informe consta de tres partes en las que se abordarán: 1) los principales rasgos característicos de la sociedad en la era digital, 2) una primera aproximación teórica del término propuesto en este trabajo de investigación, a saber: mapa comunicacional, y 3) las principales transformaciones en lo que hemos dado en llamar mapa comunicacional en los espectadores del sector audiovisual, en especial en los de la televisión de pago. Cada una de estas fases dará base expositiva del objetivo propuesto aquí y, de esta forma, poder contribuir al seguimiento y análisis de los impactos que están generando la digitalización y avances tecnológicos en el campo audiovisual.Facultad de Periodismo y Comunicación Socia