97 research outputs found
Dynamic structure of stock communities: A comparative study between stock returns and turnover rates
The detection of community structure in stock market is of theoretical and
practical significance for the study of financial dynamics and portfolio risk
estimation. We here study the community structures in Chinese stock markets
from the aspects of both price returns and turnover rates, by using a
combination of the PMFG and infomap methods based on a distance matrix. We find
that a few of the largest communities are composed of certain specific industry
or conceptional sectors and the correlation inside a sector is generally larger
than the correlation between different sectors. In comparison with returns, the
community structure for turnover rates is more complex and the sector effect is
relatively weaker. The financial dynamics is further studied by analyzing the
community structures over five sub-periods. Sectors like banks, real estate,
health care and New Shanghai take turns to compose a few of the largest
communities for both returns and turnover rates in different sub-periods.
Several specific sectors appear in the communities with different rank orders
for the two time series even in the same sub-period. A comparison between the
evolution of prices and turnover rates of stocks from these sectors is
conducted to better understand their differences. We find that stock prices
only had large changes around some important events while turnover rates surged
after each of these events relevant to specific sectors, which may offer a
possible explanation for the complexity of stock communities for turnover
rates
Octane-1,8-diyldipyridinium dibromide dihydrate
The asymmetric unit of the title compound, C18H26N2
2+·2Br−·2H2O, consists of one-half of the organic cation, one Br− anion and one water molecule. The organic cation is situated on a centre of inversion. The dihedral angle between the pyridine ring and the plane of the central linkage is 59.3 (1)°. The cations, anions and water molecules are linked via O—H⋯Br, C—H⋯Br and C—H⋯O hydrogen bonds, forming a three-dimensional framework
2,2′-(Heptane-1,7-diyl)dibenzimidazolium chloride nitrate monohydrate
In the title compound, C21H26N4
2+·Cl−·NO3
−·H2O, the organic cations, anions and water molecules are linked through N—H⋯Cl, N—H⋯O, N—H⋯N and O—H⋯Cl hydrogen bonds, forming a three-dimensional framework, assisted by C—H⋯π interactions
Sub-second periodic radio oscillations in a microquasar
Powerful relativistic jets are one of the ubiquitous features of accreting
black holes in all scales. GRS 1915+105 is a well-known fast-spinning
black-hole X-ray binary with a relativistic jet, termed as a ``microquasar'',
as indicated by its superluminal motion of radio emission. It exhibits
persistent x-ray activity over the last 30 years, with quasi-periodic
oscillations of Hz and 34 and 67 Hz in the x-ray band. These
oscillations likely originate in the inner accretion disk, but other origins
have been considered. Radio observations found variable light curves with
quasi-periodic flares or oscillations with periods of minutes.
Here we report two instances of 5 Hz transient periodic oscillation
features from the source detected in the 1.05-1.45 GHz radio band that occurred
in January 2021 and June 2022, respectively. Circular polarization was also
observed during the oscillation phase.Comment: The author version of the article which will appear in Nature on 26
July 2023, 32 pages including the extended data. The online publication
version can be found at the following URL:
https://www.nature.com/articles/s41586-023-06336-
Synergy between Proteasome Inhibitors and Imatinib Mesylate in Chronic Myeloid Leukemia
Resistance developed by leukemic cells, unsatisfactory efficacy on patients with chronic myeloid leukemia (CML) at accelerated and blastic phases, and potential cardiotoxity, have been limitations for imatinib mesylate (IM) in treating CML. Whether low dose IM in combination with agents of distinct but related mechanisms could be one of the strategies to overcome these concerns warrants careful investigation.We tested the therapeutic efficacies as well as adverse effects of low dose IM in combination with proteasome inhibitor, Bortezomib (BOR) or proteasome inhibitor I (PSI), in two CML murine models, and investigated possible mechanisms of action on CML cells. Our results demonstrated that low dose IM in combination with BOR exerted satisfactory efficacy in prolongation of life span and inhibition of tumor growth in mice, and did not cause cardiotoxicity or body weight loss. Consistently, BOR and PSI enhanced IM-induced inhibition of long-term clonogenic activity and short-term cell growth of CML stem/progenitor cells, and potentiated IM-caused inhibition of proliferation and induction of apoptosis of BCR-ABL+ cells. IM/BOR and IM/PSI inhibited Bcl-2, increased cytoplasmic cytochrome C, and activated caspases. While exerting suppressive effects on BCR-ABL, E2F1, and β-catenin, IM/BOR and IM/PSI inhibited proteasomal degradation of protein phosphatase 2A (PP2A), leading to a re-activation of this important negative regulator of BCR-ABL. In addition, both combination therapties inhibited Bruton's tyrosine kinase via suppression of NFκB.These data suggest that combined use of tyrosine kinase inhibitor and proteasome inhibitor might be helpful for optimizing CML treatment
Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors
<p>Abstract</p> <p>Background</p> <p>Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC.</p> <p>Methods</p> <p>Between January 1994 and December 2009, all patients with HCC and BM treated in Sun Yat-sen University Cancer Center were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possible prognostic factors.</p> <p>Results</p> <p>Forty-one patients were diagnosed with BM from HCC, an incidence of 0.47%. The median age at diagnosis of BM was 48.5 years. Thirty-three patients (80.5%) developed extracranial metastases at diagnosis of BM, and 30 patients (73.2%) had hepatitis B. Intracranial hemorrhage occurred in 19 patients (46.3%). BM were treated primarily either with whole brain radiation therapy (WBRT; 5 patients), stereotactic radiosurgery (SRS; 7 patients), or surgical resection (6 patients). The cause of death was systemic disease in 17 patients and neurological disease in 23. Patients in a high RPA (recursive partitioning analysis) class, treated with conservatively and without lung metastases, tended to die from neurological disease. Median survival after the diagnosis of BM was 3 months (95% confidence interval: 2.2-3.8 months). In multivariate analysis, the presence of extracranial metastases, a low RPA class and aggressive treatment, were positively associated with improved survival.</p> <p>Conclusions</p> <p>BM from HCC is rare and associated with an extremely poor prognosis. However, patients with a low RPA class may benefit from aggressive treatment. The clinical implication of extracranial metastases in HCC patients with BM needs further assessment.</p
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