A comparison of effect of preemptive use of oral gabapentin and pregabalin for acute postoperative pain after Partial Thyroidectomy

Background and Aims: Preemptive analgesia is defined as a treatment that is initiated before surgery in order to prevent the establishment of central sensitization evoked by the incisional and inflammatory injuries occurring during surgery and postoperative period. Pregabalinas considered in abolishing neuropathie component of acute nociceptive pain of surgery. Materials and methods: A study was done to know the effect of oral gabapentin and pregabalinath control group for post-operative analgesia. Materials and Methods: A total of 90 ASA grade I and II patients posted for elective Partial thyroidectomy were randomized into 3 groups (group A, B and C of 30 patients each). One hour before surgery the blinded drug selected for the study was given with a sip of water. Group C- received identical placebo tablet, Group B- received 800 mg of gabapentin tablet and Group A - received 150 mg of pregabalinablet . VAS score recorded for initial rescue analgesia, total duration of analgesia and total requirement of rescue analgesia were observed as primary outcome. Hemodynamics andside effects were recorded as secondary outcome in patients. Results: The analgesic requirement in both Pregabalinand Gabapentin groups are lower than the control group.&nbsp