Expression of Endocan in Tissue Samples from Prostate Adenocarcinoma and Prostate Hyperplasia: A Comparative Retrospective Study

Purpose: In this study, we aimed to determine whether there is a significant difference in endocan expression levels between prostate adenocarcinoma and prostate hyperplasia tissues by using an immunohistochemical method. Materials and Methods: All 51 patients, who were getting treatment for the last 5 years, participated in the study. 31 of 51 patients underwent transrectal sonography (TRUSG)-assisted prostate biopsy because of prostate adenocarcinoma as diagnosed with elevated PSA levels and histopathological examination. The remaining 20 patients comprised the control group. The control group included patients with benign prostate hyperplasia based on pathological examination. Results: It was found that there was strong positive epithelial staining in 74.2% of patients with prostate cancer while in 5% of controls, indicating a statistically significant difference (P < .001). It was also found that the rate of strong positive endothelial staining was 77.4% in the patient group whereas 5% in the control group (P < .001). Also, the rate of strong positive stromal staining was 64.5% in the patient group while 5% in the control group (P < .001). Conclusion: We found that tissue endocan expression level was statistically significantly higher in patients with prostate cancer compared to those with benign prostate hyperplasia by using an immunohistochemical method

Investigation of the Problem Solving and Excellence Levels of the Secondary School Students Who Do Sports and Does Not

In this study, it was aimed to compare the problem solving and perfectionism levels of the students who do sports and do not sports in terms of various variables, and to determine the correlation between problem solving and their perfectionism. In the province of Among the competitions between secondary schools in the 2018-2019 academic year, Milas district of Muğla province, 171 sports students between the ages of 13-15, whose sports age is at least 2 years, were randomly selected among the sports students. SPSS 22.0 statistics program was used in the analysis of the data. After the descriptive analyzes were made on the data, as the results of the Kolmogorov-Simirnov normality test performed by comparing the scores of the participants were not normal, the difference between the groups was examined by applying the Mann-Whitney test, which is one of the non-parametric tests. The "Mann-Whitney U" test was used to determine the differences between the groups. Statistical analyzes were tested at 95% confidence level, p&lt;0.05 values were considered statistically significant. Under the "spearman's rho" test for the correlation between perfectionism and problem-solving scale. As a result, although the perfectionism and problem solving levels of the students who do and do not do sports have a meaningful result, the effect of doing sports varies according to gender; We can say that there is a positive correlation in the sub-dimensions of perfectionism and problem solving skills

The Relationship Between Peyronie’s Disease and Serum Parathormone and Ionized Calcium Levels?

Aim:Peyronie’s disease’s (PD) etiology is still unclear. Many factors that may cause the disease are being investigated. The objective of our study was to clarify the effect of serum parathormone and ionized calcium levels on the pathophysiology of PD.Methods:The study was designed as a cross-sectional study. Demographic data, physical examinations, laboratory tests, and medical and sexual histories of patients between January 2017 and June 2020 were analyzed. Patients were divided into PD and control groups.Results:By measuring serum calcium and parathormone levels of patients, we analyzed 38 PD and 40 control group patients and revealed that i) parathormone (p=0.321) and ionized calcium (p=0.286) levels are not related to PD, and ii) cardiovascular disease (p=0.037), diabetes mellitus (p=0.0001), and hypertension (p=0.001) are significantly associated with PD, whereas smoking, alcohol consumption, and dyslipidemia status are not.Conclusion:The study shows that there is no relationship between serum parathormone and ionized calcium levels and the etiology of PD

The effects of delivery type and gender on intraocular pressure and central corneal thickness in newborns

ABSTRACT Purpose: To analyze intraocular pressure (IOP) and central corneal thickness (CCT) in newborns during the first 12 h of life. Methods: Forty-three newborns born by vaginal delivery (VD) and 30 newborns born by cesarean section (CS) were evaluated. IOP and CCT were measured using Tono-Pen and handheld pachymeter, respectively, at both the 5th minute after delivery and at the 12th h of life. Results: The mean IOP for the VD group was significantly higher than that of the CS group at both the 5th minute and 12th h (p =0.042 and p =0.018, respectively). In both groups, the IOP decreased by the 12th h, but the decrease was only significant for the CS group (p =0.020). The decrease in CCT over the 12 h was significant for both groups (p <0.001). In the VD and CS groups, the IOP values of the males were significantly higher than those of the females at the fifth minute only (p =0.024 and p =0.043, respectively). No other values were significantly different between the genders. Conclusions: Newborn IOP is affected by the mode of delivery and gender. A higher IOP was found in vaginally delivered newborns than in CS newborns for at least 12 h postpartum. CCT showed a significant decline within 12 h. Male newborns have significantly higher IOP values in the first minutes of life

The effects of perforated cylinders on the vortex shedding on the suppression of a circular cylinder

The aim of this study is the control of unsteady vortical flow occurred downstream of a circular cylinder located in shallow water flow using concentrically located outer perforated cylinder. The porosities, β have been changed between 0.1 and 0.8 in the present study. The increments of porosity β were taken as 0.05 in the range of 0.1 and 0.8 with a hole diameter of d=10 mm. The ratio of inner cylinder diameter to outer cylinder diameter, Di/Do was selected as 0.25, 0.3, 0.4, 0.5 and 0.6 the inner cylinder diameter is Di=50mm where the outer cylinder diameter is Dd=100mm. Experiments were performed at a constant depth of the water level as h=50mm (half of the outer cylinder diameter). Free stream velocity was taken as U∞=100 mm/s corresponding to a Reynolds number of Re Do=10000 based on the outer cylinder diameter. It has been observed that the inner circular cylinder was highly affected by the existence of surrounding outer perforated cylinders. It is observed that the intensity of Reynolds shear stress correlating, is completely attenuated in the region both downstream of concentric cylinder and between the concentric cylinders. It is determined from the experiments that porosity, β=0.55 is the most effective parameter for control of flow structure that is occurred from the inner cylinder

Is trans-radial approach related to an increased risk of radiation exposure in patients who underwent diagnostic coronary angiography or percutaneous coronary intervention? (The SAKARYA study)

Conclusion: In spite of an increased experience with trans-radial approach, PCI of coronary lesions via radial route was associated with a relatively small but significant radiation exposure in our study. Compared to femoral access, diagnostic CA via radial access was not related to an increased radiation exposure

The mediating role of self/everyday creativity and depression on the relationship between creative personality traits and problematic social media use among emerging adults

Personality is one of the important contributory factors in the development of problematic technology use. The purpose of the present study was to investigate the direct and indirect associations of creative personality traits with problematic social media use via self/everyday creativity, depression, and loneliness. A total of 460 Turkish emerging adults aged between 18 and 26 years (61% female) were surveyed. Findings indicated that (i) task-orientedness was indirectly associated with problematic social media use via self/everyday creativity, (ii) self-confidence was directly and indirectly associated with problematic social media use via self/everyday creativity and depression, (iii) risk-taking was indirectly associated with problematic social media use via depression, and (iv) self/everyday creativity and depression were directly associated with problematic social media use. The present study is the first to suggest that creative personality traits (i.e., task-orientedness, self-confidence, and risk-taking) and self/everyday creativity are associated with problematic social media use and that these factors should be taken into account when considering the etiology of problematic social media use

Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study

Purpose: The incidence, patient features, risk factors and outcomes of surgery-associated postoperative acute kidney injury (PO-AKI) across different countries and health care systems is unclear. Methods: We conducted an international prospective, observational, multi-center study in 30 countries in patients undergoing major surgery (&gt; 2-h duration and postoperative intensive care unit (ICU) or high dependency unit admission). The primary endpoint was the occurrence of PO-AKI within 72&nbsp;h of surgery defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Secondary endpoints included PO-AKI severity and duration, use of renal replacement therapy (RRT), mortality, and ICU and hospital length of stay. Results: We studied 10,568 patients and 1945 (18.4%) developed PO-AKI (1236 (63.5%) KDIGO stage 1500 (25.7%) KDIGO stage 2209 (10.7%) KDIGO stage 3). In 33.8% PO-AKI was persistent, and 170/1945 (8.7%) of patients with PO-AKI received RRT in the ICU. Patients with PO-AKI had greater ICU (6.3% vs. 0.7%) and hospital (8.6% vs. 1.4%) mortality, and longer ICU (median 2 (Q1-Q3, 1-3) days vs. 3 (Q1-Q3, 1-6) days) and hospital length of stay (median 14 (Q1-Q3, 9-24) days vs. 10 (Q1-Q3, 7-17) days). Risk factors for PO-AKI included older age, comorbidities (hypertension, diabetes, chronic kidney disease), type, duration and urgency of surgery as well as intraoperative vasopressors, and aminoglycosides administration. Conclusion: In a comprehensive multinational study, approximately one in five patients develop PO-AKI after major surgery. Increasing severity of PO-AKI is associated with a progressive increase in adverse outcomes. Our findings indicate that PO-AKI represents a significant burden for health care worldwide

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely