Conjunctival Metastasis as an Initial Sign of Small Cell Lung Cancer

Introduction. To report a case of a conjunctival metastasis as the initial manifestation of small cell lung cancer. Methods. Observational case report. Results. A 50-year-old man without known systemic disease developed a conjunctival mass in his right eye. He underwent incisional biopsy of the tumor and systemic evaluation. Histopathologically, the conjunctival mass was a metastatic small cell carcinoma. Further evaluation revealed a primary small cell lung carcinoma with metastasis to liver and bones. The primary and metastatic tumors were treated with chemotherapy. Conclusion. Conjunctival metastasis may be the initial manifestation of lung cancer. It should be considered in the differential diagnosis of a deep conjunctival mass

Peripheral blood stem cell collection for allogeneic hematopoietic stern cell transplantation: Practical implications after 200 consequent transplants

WOS: 000423246100008Background: Proper stem cell mobilization is one of the most important steps in hematopoietic stem cell transplantation (HSCT). The aim of this paper is to share our 6 years' experience and provide practical clinical approaches particularly for stem cell mobilization and collection within the series of more than 200 successive allogeneic HSCT at our transplant center. Subjects & Methods: Two hundred and seven consecutive patients who underwent allogeneic peripheral blood stem cell transplantation were included in this study. Age, sex, weight, complete blood counts, CD34(+) cell counts, total collected amount of CD34(+) cells, CD34(+) cells per 101 processed, mobilization failure and adverse events were reviewed. Results: Median age was 40.2 +/- 12.9 (21-68) years and 46.4 +/- 13.4 (17-67) years for donors and patients, respectively. The number of donors who had undergone adequate CD34(+) cell harvesting and completed the procedure on the fourth day was 67 (32.8% of all patients). Only 12 patients required cell apheresis both on day 5 and 6. Apheresis was completed on day 4 and/or day 5 in 94.2% of all our donors. There was no significant association between CD34(+) stem cell volume and age, gender and weight values of donors. Mobilization failure was not seen in our series. Conclusions: G-CSF is highly effective in 1/3 of the donors on the 4th day in order to collect enough number of stem cells. We propose that peripheral stem cell collection might start on day 4th of G-CSF treatment for avoiding G-CSF related side effects and complications. (C) 2017 Elsevier Ltd. All rights reserved

Case Report Conjunctival Metastasis as an Initial Sign of Small Cell Lung Cancer

Introduction. To report a case of a conjunctival metastasis as the initial manifestation of small cell lung cancer. Methods. Observational case report. Results. A 50-year-old man without known systemic disease developed a conjunctival mass in his right eye. He underwent incisional biopsy of the tumor and systemic evaluation. Histopathologically, the conjunctival mass was a metastatic small cell carcinoma. Further evaluation revealed a primary small cell lung carcinoma with metastasis to liver and bones. The primary and metastatic tumors were treated with chemotherapy. Conclusion. Conjunctival metastasis may be the initial manifestation of lung cancer. It should be considered in the differential diagnosis of a deep conjunctival mass

Impact of an Established National Donor Registry on Transplant Outcome: Turkok Experience in Turkey

Transplantation and Cellular Therapy (TCT) Meetings of ASTCT and CIBMTR -- FEB 19-23, 2020 -- Orlando, FLWOS: 000516887900445[No abstract available]Amer Soc Transplantat & Cellular Therapy, CIBMT

Should We Start Peripheral Blood Stem Cell Collection for Allogeneic Transplantation on the Fifth Day?

Blood and Marrow Transplantion Tandem Meetings of the Center-for-International-Blood-and-Marrow-Transplant-Research (CIBMTR) / American-Society-for-Blood-and-Marrow-Transplantation (ASBMT) -- FEB 21-25, 2018 -- Salt Lake City, UTWOS: 000425476000427…Ctr Int Blood & Marrow Transplant Res, Amer Soc Blood & Marrow Transplanta

Can Rotational Thromboelastometry be a New Predictive Tool for Retinal Vein Occlusion Development?

WOS: 000464751200004PubMed ID: 30512971Purpose: To evaluate clotting dynamics by a new tool called rotational tromboelastometry (ROTEM) in retinal vein occlusion.Materials and methods: Thirty-six patients who were diagnosed with retinal vein occlusion and 43 age and sex matched healthy controls were included in this study. Diabetes and use of anticoagulant therapy were exclusion criteria. All study participants underwent detailed ophthalmologic and systemic medical examination, including blood pressure measurement, hemoglobin-hematocrit levels, platelet count, coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels. Peripheral blood samples were collected and analyzed with ROTEM Coagulation Analyzer (Tem International, Munich, Germany).Results: The RVO patients and controls did not differ with respect to age, sex, hemoglobin, hematocrit, platelet numbers, prothrombin time, activated partial thromboplastin time, fibrinogen levels, D-dimer levels, and glucose levels. When extrinsic thromboelastometry results were analyzed, RVO patients showed a significantly decreased clotting time (76.515.0 vs. 95.0 +/- 21s, respectively; p =0.01) and clot formation time (83.3 +/- 22 vs. 99.7 +/- 24s; p =0.01) as compared with healthy controls. Other ROTEM parameters did now show any difference between two groups.Conclusion: Patients with retinal vein occlusion showed faster clotting time and shorter clotting formation time as compared with healthy controls. ROTEM detects the altered clotting dynamics and may be a useful tool to elucidate the disease pathophysiology. Further studies are needed to investigate if it can be used as a screening test for individuals who are under risk to develop RVO or as a first step test to evaluate hypercoagulable state in RVO

The Impact of Foundation of the National Turkish Donor Registry, Turkok on Donor Matching Kinetics

44th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT) -- MAR 18-21, 2018 -- Lisbon, PORTUGALArat, Mutlu/0000-0003-2039-8557WOS: 000487702805055[No abstract available]European Soc Blood & Marrow Transplanta