Aerosol particle transport and deposition in a CT-based lung airway for helium-oxygen mixture

© 2018 Australasian Fluid Mechanics Society. All rights reserved. A precise understanding of the aerosol particle transport and deposition (TD) in the human lung is important to improve the efficiency of the targeted drug delivery, as the current drug delivery device can deliver only a small amount of the drug to the terminal airways. A wide range of available computational and experimental model has improved the understanding of particle TD in the human lung for air breathing. However, the helium-oxygen gas mixture breathing is less dense than the air breathing and the turbulent dispersion is less likely to develop at the upper airways, which eventually reduce the higher deposition at the upper airways. This study aims to investigate the effects of the helium-oxygen gas mixture at the upper airways of a realistic human lung. A realistic lung model is developed from the CT-Scan data for a healthy adult. A Low Reynolds Number (LRN) k-ω model is used to calculate the fluid motion and Lagrangian particle tracking scheme is used for particle transport. ANSYS Fluent solver (19.0) is used for the numerical simulation and MATLAB software is used for the advanced post-processing. The numerical results show that helium-oxygen gas mixture breathing reduces the aerosol deposition at the upper airways than the air breathing. The present simulation along with more case-specific investigation will improve the understanding of the particle TD for the helium-oxygen mixture

Ultrafine particle transport and deposition in the upper airways of a CT-based realistic lung

© 2018 Australasian Fluid Mechanics Society. All rights reserved. The understanding of the toxic pollutant particles transport and deposition is important for dosimetry and respiratory health effects analysis. The studies over the last few decades for ultrafine particle transport and deposition improves the understanding of the drug-aerosol impacts in the extrathoracic airways. A limited number of studies has also considered upper airways and almost all of those studies used the non-realistic smooth surface for upper airway model. However, the smooth surface anatomical model is far from the realistic lung and it is important to consider realistic lung model for better prediction of ultrafine particle deposition. This study aims to simulate the ultrafine particle transport and deposition in the upper airways of a highly asymmetric CT-based model. The anatomically explicit digital airway model is generated from the high-resolution CT data of a healthy adult. Unstructured tetrahedral mesh throughout the geometry and fine inflation layer mesh near the wall is generated. Euler-Lagrange (E-L) approach and ANSYS Fluent solver (18.2) are used to investigate the ultrafine particle transport and deposition. A wide range of diameter (1 ≤ nm ≤ 1000) and different flow rates are considered for the ultrafine particle simulation. Pressure drop is calculated for right and left lobes which might be helpful for the therapeutic purpose of the asthma patient. The numerical study shows that the deposition efficiency in the right lung and the left lung is different for dissimilar flow rates, which could help the health risk assessment of the respiratory diseases and eventually could help the targeted drug delivery system

Multiple-relaxation-time lattice Boltzmann simulation of natural convection flow in a partitioned cavity using GPU computing

© 2019 Author(s). In this paper, we demonstrated the implementation of General Purpose Graphics Processing Unit (GPGPU) programming in Compute Unified Device Architecture (CUDA) C for the simulation of natural convection flow in a side-heated three-dimensional (3D) rectangular cavity with a partition. In the present lattice Boltzmann method (LBM) D3Q19 multiple-relaxation-time (MRT) and D3Q6 single relaxation-time (SRT) model are implemented for the simulation of fluid flow and temperature phenomena, respectively. The parallel code is validated with the benchmark problem of a side heated cubic cavity. The results are presented by the temperature distribution in terms of isotherms, local and average Nusselt number and 3D view of iso-surface for the different Rayleigh number (Ra) and the Prandtl number fixed at Pr = 0.71. It is also observed that the present parallel implementation of the MRT-lattice Boltzmann simulation in GPU has a substantial computational effciency rather than the sequential programming in central processing units (CPU)

A macroscopic particle modelling approach for non-isothermal solid-gas and solid-liquid flows through porous media

© 2019 Elsevier Ltd The complexity of multiphase flows in many engineering systems such as heat exchangers signify the need to develop new and advanced numerical models to analyse the interactions the working fluid and unwanted solid foulants. Fouling is present in a myriad of industrial and domestic processes and it has a negative impact on the economy and the environment. The mechanisms that govern non-isothermal solid-fluid flow through porous metal foam heat exchangers are complex and poorly understood. In this research, a coupled finite volume method (FVM) and macroscopic particle model (MPM) is developed and implemented in ANSYS Fluent to examine the transient evolution of a non-isothermal multiphase solid-fluid flow and the interaction between coupled interactions of solid particles, fluid, and porous media. The maximum particle temperature is dependent on the fluid and solid particle thermo-physical properties in addition to the temperature of the cylindrical ligaments of the porous media. The present results show that the smallest solid particles reach the highest temperatures in the porous heat exchanger and at low inlet velocities, the highest particle temperatures are realized. The results pertaining to maximum particle temperatures are prevalent in many industrial processes and acquiring knowledge of the maximum particle temperature serves as a steppingstone for comprehending complex multiphase solid-fluid flows such as the cohesiveness between the particles and the particle adhesion with the walls. The results of these studies could potentially be used in the future to optimize metal foam heat exchanger designs

Comparison of different solar-assisted air conditioning systems for Australian office buildings

© 2017 by the authors. This study has investigated the feasibility of three different solar-assisted air conditioning systems for typical medium-sized office buildings in all eight Australian capital cities using the whole building energy simulation software EnergyPlus. The studied solar cooling systems include: solar desiccant-evaporative cooling (SDEC) system, hybrid solar desiccant-compression cooling (SDCC) system, and solar absorption cooling (SAC) system. A referenced conventional vapor compression variable-air-volume (VAV) system has also been investigated for comparison purpose. The technical, environmental, and economic performances of each solar cooling system have been evaluated in terms of solar fraction (SF), system coefficient of performance (COP), annual HVAC (heating, ventilation, and air conditioning) electricity consumption, annual CO2 emissions reduction, payback period (PBP), and net present value (NPV). The results demonstrate that the SDEC system consumes the least energy in Brisbane and Darwin, achieving 56.9% and 82.1% annual energy savings, respectively, compared to the conventional VAV system, while for the other six cities, the SAC system is the most energy efficient. However, from both energy and economic aspects, the SDEC system is more feasible in Adelaide, Brisbane, Darwin, Melbourne, Perth, and Sydney because of high annual SF and COP, low yearly energy consumption, short PBP and positive NPV, while for Canberra and Hobart, although the SAC system achieves considerable energy savings, it is not economically beneficial due to high initial cost. Therefore, the SDEC system is the most economically beneficial for most of Australian cities, especially in hot and humid climates. The SAC system is also energy efficient, but is not as economic as the SDEC system. However, for Canberra and Hobart, reducing initial cost is the key point to achieve economic feasibility of solar cooling applications

Parametric analysis of design parameter effects on the performance of a solar desiccant evaporative cooling system in brisbane, Australia

© 2017 by the authors. Solar desiccant cooling is widely considered as an attractive replacement for conventional vapor compression air conditioning systems because of its environmental friendliness and energy efficiency advantages. The system performance of solar desiccant cooling strongly depends on the input parameters associated with the system components, such as the solar collector, storage tank and backup heater, etc. In order to understand the implications of different design parameters on the system performance, this study has conducted a parametric analysis on the solar collector area, storage tank volume, and backup heater capacity of a solid solar desiccant cooling system for an office building in Brisbane, Australia climate. In addition, a parametric analysis on the outdoor air humidity ratio control set-point which triggers the operation of the desiccant wheel has also been investigated. The simulation results have shown that either increasing the storage tank volume or increasing solar collector area would result in both increased solar fraction (SF) and system coefficient of performance (COP), while at the same time reduce the backup heater energy consumption. However, the storage tank volume is more sensitive to the system performance than the collector area. From the economic aspect, a storage capacity of 30 m3/576 m2 has the lowest life cycle cost (LCC) of 405,954 for the solar subsystem. In addition, 100 kW backup heater capacity is preferable for the satisfaction of the design regeneration heating coil hot water inlet temperature set-point with relatively low backup heater energy consumption. Moreover, an outdoor air humidity ratio control set-point of 0.008 kgWater/kgDryAir is more reasonable, as it could both guarantee the indoor design conditions and achieve low backup heater energy consumption

Computational Modelling of the Interaction of Gold Nanoparticle with Lung Surfactant Monolayer

Copyright © Materials Research Society 2019. Lung surfactant (LS), a thin layer of phospholipids and proteins inside the alveolus of the lung is the first biological barrier to inhaled nanoparticles (NPs). LS stabilizes and protects the alveolus during its continuous compression and expansion by fine-Tuning the surface tension at the air-water interface. Previous modelling studies have reported the biophysical function of LS monolayer and its role, but many open questions regarding the consequences and interactions of airborne nano-sized particles with LS monolayer remain. In spite of gold nanoparticles (AuNPs) having a paramount role in biomedical applications, the understanding of the interactions between bare AuNPs (as pollutants) and LS monolayer components still unresolved. Continuous inhalation of NPs increases the possibility of lung ageing, reducing the normal lung functioning and promoting lung malfunction, and may induce serious lung diseases such as asthma, lung cancer, acute respiratory distress syndrome, and more. Different medical studies have shown that AuNPs can disrupt the routine lung functions of gold miners and promote respiratory diseases. In this work, coarse-grained molecular dynamics simulations are performed to gain an understanding of the interactions between bare AuNPs and LS monolayer components at the nanoscale. Different surface tensions of the monolayer are used to mimic the biological process of breathing (inhalation and exhalation). It is found that the NP affects the structure and packing of the lipids by disordering lipid tails. Overall, the analysed results suggest that bare AuNPs impede the normal biophysical function of the lung, a finding that has beneficial consequences to the potential development of treatments of various respiratory diseases

Aerosol particle transport and deposition in a CT-scan based mouth-throat model

© 2019 Author(s). A precise understanding of the aerosol particle transport and deposition (TD) in the realistic mouth-throat model is important for the respiratory health risk assessment and effective delivery of the aerosol medicine to the targeted positions of the lung. A wide range of studies have developed the particle TD framework for both idealized and non-idealized extra-thoracic airways. However, all of the existing in silico and experimental model reports a significant amount of aerosol particles are deposit at the extra-thoracic airways and the existing drug delivery device can deliver only 12 percent of the aerosol drug to the targeted position of the lung. This study aims to increase the efficiency of the targeted drug delivery by developing a realistic particle transport model for CT-Scan based mouth-throat replica. A 3-D realistic mouth-throat model is developed from the CT-Scan DiCom images of a healthy adult cast. High-Quality computational cells are generated for the replica model and the proper grid refinement test has been performed. ANSYS Fluent (19.1) solver is used for the particle TD computation. Tecplot and MATLAB software are used for the post-processing purpose. The numerical results report that the breathing pattern and particle diameter influences the overall particle TD in the mouth-throat model. The numerical results also depict different deposition hot spots for the mouth-throat model, which will eventually help to design a better drug delivery device. The numerical results reported that only 13.67 percent of the 10-μm diameter particles are deposited at the mouth-throat model at 15 lpm flow rate and which indicate that the remaining particles will move to the beyond airways. The present results along with more case studies will develop the understanding of the realistic particle deposition in the extrathoracic airways

Helium-Oxygen Mixture Model for Particle Transport in CT-Based Upper Airways.

The knowledge of respiratory particle transport in the extra-thoracic pathways is essential for the estimation of lung health-risk and optimization of targeted drug delivery. The published literature reports that a significant fraction of the inhaled aerosol particles are deposited in the upper airways, and available inhalers can deliver only a small amount of drug particles to the deeper airways. To improve the targeted drug delivery efficiency to the lungs, it is important to reduce the drug particle deposition in the upper airways. This study aims to minimize the unwanted aerosol particle deposition in the upper airways by employing a gas mixture model for the aerosol particle transport within the upper airways. A helium-oxygen (heliox) mixture (80% helium and 20% oxygen) model is developed for the airflow and particle transport as the heliox mixture is less dense than air. The mouth-throat and upper airway geometry are extracted from CT-scan images. Finite volume based ANSYS Fluent (19.2) solver is used to simulate the airflow and particle transport in the upper airways. Tecplot software and MATLAB code are employed for the airflow and particle post-processing. The simulation results show that turbulence intensity for heliox breathing is lower than in the case of air-breathing. The less turbulent heliox breathing eventually reduces the deposition efficiency (DE) at the upper airways than the air-breathing. The present study, along with additional patient-specific investigation, could improve the understanding of particle transport in upper airways, which may also increase the efficiency of aerosol drug delivery

A novel numerical model to predict the morphological behavior of magnetic liquid marbles using coarse grained molecular dynamics concepts

© 2018 Author(s). Liquid marbles are liquid droplets coated with superhydrophobic powders whose morphology is governed by the gravitational and surface tension forces. Small liquid marbles take spherical shapes, while larger liquid marbles exhibit puddle shapes due to the dominance of gravitational forces. Liquid marbles coated with hydrophobic magnetic powders respond to an external magnetic field. This unique feature of magnetic liquid marbles is very attractive for digital microfluidics and drug delivery systems. Several experimental studies have reported the behavior of the liquid marbles. However, the complete behavior of liquid marbles under various environmental conditions is yet to be understood. Modeling techniques can be used to predict the properties and the behavior of the liquid marbles effectively and efficiently. A robust liquid marble model will inspire new experiments and provide new insights. This paper presents a novel numerical modeling technique to predict the morphology of magnetic liquid marbles based on coarse grained molecular dynamics concepts. The proposed model is employed to predict the changes in height of a magnetic liquid marble against its width and compared with the experimental data. The model predictions agree well with the experimental findings. Subsequently, the relationship between the morphology of a liquid marble with the properties of the liquid is investigated. Furthermore, the developed model is capable of simulating the reversible process of opening and closing of the magnetic liquid marble under the action of a magnetic force. The scaling analysis shows that the model predictions are consistent with the scaling laws. Finally, the proposed model is used to assess the compressibility of the liquid marbles. The proposed modeling approach has the potential to be a powerful tool to predict the behavior of magnetic liquid marbles serving as bioreactors