Bilateral Serous Retinal Detachment as a Presenting Sign of Acute Lymphoblastic Leukemia

We present a case of bilateral serous retinal detachment (SRD) as a presenting sign of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). A 45-year-old woman presented with decreased vision and was found to have bilateral serous retinal detachment. Peripheral blood smears revealed leukocytosis of 53.9×103/µL with 64.6% lymphoblasts. A bone marrow aspirate revealed the presence of lymphoblasts. Cytogenetic and molecular genetic analysis detected a reciprocal translocation between chromosome 9 and 22, t(9;22) (q34;q11). A diagnosis of Ph+ ALL was made. Following systemic chemotherapy, the bilateral SRD resolved completely with full recovery of vision. The sudden appearance of SRD should raise suspicion for leukemia. Prompt recognition of this disease is important for early systemic treatment and restoration of visual function

C-ITS Environment Modeling and Attack Modeling

As technology advances, cities are evolving into smart cities, with the ability to process large amounts of data and the increasing complexity and diversification of various elements within urban areas. Among the core systems of a smart city is the Cooperative-Intelligent Transport Systems (C-ITS). C-ITS is a system where vehicles provide real-time information to drivers about surrounding traffic conditions, sudden stops, falling objects, and other accident risks through roadside base stations. It consists of road infrastructure, C-ITS centers, and vehicle terminals. However, as smart cities integrate many elements through networks and electronic control, they are susceptible to cybersecurity issues. In the case of cybersecurity problems in C-ITS, there is a significant risk of safety issues arising. This technical document aims to model the C-ITS environment and the services it provides, with the purpose of identifying the attack surface where security incidents could occur in a smart city environment. Subsequently, based on the identified attack surface, the document aims to construct attack scenarios and their respective stages. The document provides a description of the concept of C-ITS, followed by the description of the C-ITS environment model, service model, and attack scenario model defined by us.Comment: in Korean Language, 14 Figures, 15 Page

Synthesis of chiral malonates by α-alkylation of 2,2-diphenylethyl tert-butyl malonates via enantioselective phase-transfer catalysis

An efficient synthetic approach for chiral malonates was established via enantioselective phase transfer catalysis. The α-alkylation of 2,2-diphenylethyl tert-butyl α-methylmalonates with (S,S)-3,4,5-trifluorophenyl-NAS bromide as a phase-transfer catalyst under phase-transfer catalytic conditions successfully produced corresponding α-methyl-α-alkylmalonates; these compounds are versatile chiral building blocks containing a quaternary carbon center in high chemical yields (up to 99%) with excellent enantioselectivities (up to 98% ee). α,α-Dialkylmalonates were selectively hydrolyzed to the corresponding chiral malonic monoacids under basic (KOH/MeOH) and acidic conditions (TFA/CH2Cl2), showing the practicality of the method

Intravitreal Bevacizumab for the Treatment of Neovascular Glaucoma Associated With Central Retinal Artery Occlusion

We report three cases of neovascular glaucoma secondary to central retinal artery occlusion (CRAO) which were effectively managed with intravitreal bevacizumab (IVB) followed by panretinal photocoagulation (PRP). Neovascular glaucoma without peripheral anterior synechiae developed between one and five weeks following CRAO onset. All patients received 0.75 mg (0.03 ml) IVB. In all patients, complete regression of the iris and anterior chamber angle neovascularization was confirmed within one week. PRP was applied two weeks after the injection. The follow-up period was four to seven months (average, five months). Intraocular pressure was controlled in all patients using topical antiglaucoma medications alone. However, one patient experienced a recurrence of neovascularization three months after the initial combination treatment. This patient received another IVB injection and additional PRP, and the recurrent neovascularization resolved. There were no local or systemic adverse events in any patients. Therefore, intravitreal bevacizumab may be an effective adjunct in the treatment of neovascular glaucoma associated with CRAO

AI-based Attack Graph Generation

With the advancement of IoT technology, many electronic devices are interconnected through networks, communicating with each other and performing specific roles. However, as numerous devices join networks, the threat of cyberattacks also escalates. Preventing and detecting cyber threats are crucial, and one method of preventing such threats involves using attack graphs. Attack graphs are widely used to assess security threats within networks. However, a drawback emerges as the network scales, as generating attack graphs becomes time-consuming. To overcome this limitation, artificial intelligence models can be employed. By utilizing AI models, attack graphs can be created within a short period, approximating optimal outcomes. AI models designed for attack graph generation consist of encoders and decoders, trained using reinforcement learning algorithms. After training the AI models, we confirmed the model's learning effectiveness by observing changes in loss and reward values. Additionally, we compared attack graphs generated by the AI model with those created through conventional methods.Comment: in Korean Language, 8 Figures, 14 Page