A study of the X-rayed outflow of APM 08279+5255 through photoionization codes

We present new results from our study of the X-rayed outflow of the z = 3.91 gravitationally lensed broad absorption line (BAL) quasar APM 08279+5255. These results are based on spectral fits to all the long exposure observations of APM 08279+5255 using a new quasar-outflow model. This model is based on cloudy simulations of a near-relativistic quasar outflow. The main conclusions from our multi-epoch spectral re-analysis of Chandra, XMM-Newton and Suzaku observations of APM 08279+5255 are: 1) In every observation we confirm the presence of two strong features, one at rest-frame energies between 1-4 keV, and the other between 7-18 keV. 2) We confirm that the low-energy absorption (1-4 keV rest-frame) arises from a low-ionization absorber with logNH~23 and the high-energy absorption (7-18 keV rest-frame) arises from highly ionized (3>log xi>4; where xi is the ionization parameter) iron in a near-relativistic outflowing wind. Assuming this interpretation, we find that the velocities on the outflow could get up to ~0.7c. 3) We confirm a correlation between the maximum outflow velocity and the photon index and find possible trends between the maximum outflow velocity and the X-ray luminosity, and between the total column density and the photon index. We performed calculations of the force multipliers of material illuminated by absorbed power laws and a Mathews-Ferland SED. We found that variations of the X-ray and UV parts of the SEDs and the presence of a moderate absorbing shield will produce important changes in the strength of the radiative driving force. These results support the observed trend found between the outflow velocity and X-ray photon index in APM 08279+5255. If this result is confirmed it will imply that radiation pressure is an important mechanism in producing quasar outflows.Comment: Paper accepted in the Astrophysical journa

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer\u27s Disease, ALS, and Harmful Stress Conditions

Considered relevant during allergy responses, numerous observations have also identified mast cells (MCs) as critical effectors during the progression and modulation of several neuroinflammatory conditions, including Alzheimer\u27s disease (AD) and amyotrophic lateral sclerosis (ALS). MC granules contain a plethora of constituents, including growth factors, cytokines, chemokines, and mitogen factors. The release of these bioactive substances from MCs occurs through distinct pathways that are initiated by the activation of specific plasma membrane receptors/channels. Here, we focus on hemichannels (HCs) formed by connexins (Cxs) and pannexins (Panxs) proteins, and we described their contribution to MC degranulation in AD, ALS, and harmful stress conditions. Cx/Panx HCs are also expressed by astrocytes and are likely involved in the release of critical toxic amounts of soluble factors-such as glutamate, adenosine triphosphate (ATP), complement component 3 derivate C3a, tumor necrosis factor (TNFalpha), apoliprotein E (ApoE), and certain miRNAs-known to play a role in the pathogenesis of AD, ALS, and other neurodegenerative disorders. We propose that blocking HCs on MCs and glial cells offers a promising novel strategy for ameliorating the progression of neurodegenerative diseases by reducing the release of cytokines and other pro-inflammatory compounds

MULTI-SIGHTLINE OBSERVATION OF NARROW ABSORPTION LINES IN LENSED QUASAR SDSS J1029+2623

We exploit the widely separated images of the lensed quasar SDSS J1029+2623 (z(em) = 2.197, theta = 22.'' 5) to observe its outflowing wind through two different sightlines. We present an analysis of three observations, including two with the Subaru telescope in 2010 February and 2014 April, separated by four years, and one with the Very Large Telescope, separated from the second Subaru observation by similar to 2 months. We detect 66 narrow absorption lines (NALs), of which 24 are classified as intrinsic NALs that are physically associated with the quasar based on partial coverage analysis. The velocities of intrinsic NALs appear to cluster around values of v(ej) similar to 59,000, 43,000, and 29,000 km s(-1), which is reminiscent of filamentary structures obtained by numerical simulations. There are no common intrinsic NALs at the same redshift along the two sightlines, implying that the transverse size of the NAL absorbers should be smaller than the sightline distance between two lensed images. In addition to the NALs with large ejection velocities of v(ej) > 1000 km s(-1), we also detect broader proximity absorption lines (PALs) at za(bs) similar to z(em). The PALs are likely to arise in outflowing gas at a distance of r = 8.7 x 10(3) cm(-3). These limits are based on the assumption that the variability of the lines is due to recombination. We discuss the implications of these results on the three-dimensional structure of the outflow.ArticleASTROPHYSICAL JOURNAL.825(1):25(2016)journal articl

Channelling carbon flux through the meta-cleavage route for improved poly(3-hydroxyalkanoate) production from benzoate and lignin-based aromatics in Pseudomonas putida H

Lignin-based aromatics are attractive raw materials to derive medium-chain length poly(3-hydroxyalkanoates) (mcl-PHAs), biodegradable polymers of commercial value. So far, this conversion has exclusively used the ortho-cleavage route of Pseudomonas putida KT2440, which results in the secretion of toxic intermediates and limited performance. Pseudomonas putida H exhibits the ortho- and the meta-cleavage pathways where the latter appears promising because it stoichiometrically yields higher levels of acetyl-CoA. Here, we created a double-mutant H-ΔcatAΔA2 that utilizes the meta route exclusively and synthesized 30% more PHA on benzoate than the parental strain but suffered from catechol accumulation. The single deletion of the catA2 gene in the H strain provoked a slight attenuation on the enzymatic capacity of the ortho route (25%) and activation of the meta route by nearly 8-fold, producing twice as much mcl-PHAs compared to the wild type. Inline, the mutant H-ΔcatA2 showed a 2-fold increase in the intracellular malonyl-CoA abundance – the main precursor for mcl-PHAs synthesis. As inferred from flux simulation and enzyme activity assays, the superior performance of H-ΔcatA2 benefited from reduced flux through the TCA cycle and malic enzyme and diminished by-product formation. In a benzoate-based fed-batch, P. putida H-ΔcatA2 achieved a PHA titre of 6.1 g l–1 and a volumetric productivity of 1.8 g l–1 day–1. Using Kraft lignin hydrolysate as feedstock, the engineered strain formed 1.4 g l- 1 PHA. The balancing of carbon flux between the parallel catechol-degrading routes emerges as an important strategy to prevent intermediate accumulation and elevate mcl-PHA production in P. putida H and, as shown here, sets the next level to derive this sustainable biopolymer from lignin hydrolysates and aromatics

Field quality of 1.5 m long conduction cooled superconducting undulator coils with 20 mm period length

The Institute for Beam Physics and Technology (IBPT) at the Karlsruhe Institute of Technology (KIT) and the industrial partner Babcock Noell GmbH (BNG) are collaborating since 2007 on the development of superconducting undulators both for ANKA and low emittance light sources. The first full length device with 15 mm period length has been successfully tested in the ANKA storage ring for one year. The next superconducting undulator has 20 mm period length (SCU20) and is also planned to be installed in the accelerator test facility and synchrotron light source ANKA. The SCU20 1.5 m long coils have been characterized in a conduction cooled horizontal test facility developed at KIT IBPT. Here we present the local magnetic field and field integral measurements, as well as their analysis including the expected photon spectrum

Programación paralela en sistemas híbridos

Con la aparición de las CPU multi-cores (o Chiplevel- Multi-Processor -CMP-), es importante el desarrollo de las técnicas que exploten las ventajas de las CMP para acelerar las aplicaciones paralelas que poseen una gran demanda de cómputo paralelo. En particular, las aplicaciones que requieren de un gran poder computacional de los recursos disponibles, es esencial poder desarrollar estrategias y algoritmos que aprovechen el uso adecuado del hardware. Esto es especialmente crítico cuando se consideran sistemas o aplicaciones en las que los requerimientos ingresan en intervalos variables. En este trabajo se propone el desarrollo de técnicas híbridas basadas en el uso de MPI para la comunicación entre procesadores y OpenMP para la comunicación entre cores de un mismo procesador. OpenMP ha sido desarrollado para tomar ventaja de las facilidades multithreading de los nodos CMP.Eje: Procesamiento Distribuido y ParaleloRed de Universidades con Carreras en Informática (RedUNCI

Programación paralela en sistemas híbridos

Con la aparición de las CPU multi-cores (o Chiplevel- Multi-Processor -CMP-), es importante el desarrollo de las técnicas que exploten las ventajas de las CMP para acelerar las aplicaciones paralelas que poseen una gran demanda de cómputo paralelo. En particular, las aplicaciones que requieren de un gran poder computacional de los recursos disponibles, es esencial poder desarrollar estrategias y algoritmos que aprovechen el uso adecuado del hardware. Esto es especialmente crítico cuando se consideran sistemas o aplicaciones en las que los requerimientos ingresan en intervalos variables. En este trabajo se propone el desarrollo de técnicas híbridas basadas en el uso de MPI para la comunicación entre procesadores y OpenMP para la comunicación entre cores de un mismo procesador. OpenMP ha sido desarrollado para tomar ventaja de las facilidades multithreading de los nodos CMP.Eje: Procesamiento Distribuido y ParaleloRed de Universidades con Carreras en Informática (RedUNCI

NuSTAR observations of the powerful radio-galaxy Cygnus A

We present NuSTAR observations of the powerful radio galaxy Cygnus A, focusing on the central absorbed active galactic nucleus (AGN). Cygnus A is embedded in a cool-core galaxy cluster, and hence we also examine archival XMM-Newton data to facilitate the decomposition of the spectrum into the AGN and intracluster medium (ICM) components. NuSTAR gives a source-dominated spectrum of the AGN out to >70keV. In gross terms, the NuSTAR spectrum of the AGN has the form of a power law (Gamma~1.6-1.7) absorbed by a neutral column density of N_H~1.6x10^23 cm^-2. However, we also detect curvature in the hard (>10keV) spectrum resulting from reflection by Compton-thick matter out of our line-of-sight to the X-ray source. Compton reflection, possibly from the outer accretion disk or obscuring torus, is required even permitting a high-energy cutoff in the continuum source; the limit on the cutoff energy is E_cut>111keV (90% confidence). Interestingly, the absorbed power-law plus reflection model leaves residuals suggesting the absorption/emission from a fast (15,000-26,000km/s), high column-density (N_W>3x10^23 cm^-2), highly ionized (xi~2,500 erg cm/s) wind. A second, even faster ionized wind component is also suggested by these data. We show that the ionized wind likely carries a significant mass and momentum flux, and may carry sufficient kinetic energy to exercise feedback on the host galaxy. If confirmed, the simultaneous presence of a strong wind and powerful jets in Cygnus A demonstrates that feedback from radio-jets and sub-relativistic winds are not mutually exclusive phases of AGN activity but can occur simultaneously.Comment: 13 pages; accepted for publication in The Astrophysical Journa