Structure in 6D and 4D N=1 supergravity theories from F-theory

We explore some aspects of 4D supergravity theories and F-theory vacua that are parallel to structures in the space of 6D theories. The spectrum and topological terms in 4D supergravity theories correspond to topological data of F-theory geometry, just as in six dimensions. In particular, topological axion-curvature squared couplings appear in 4D theories; these couplings are characterized by vectors in the dual to the lattice of axion shift symmetries associated with string charges. These terms are analogous to the Green-Schwarz terms of 6D supergravity theories, though in 4D the terms are not generally linked with anomalies. We outline the correspondence between F-theory topology and data of the corresponding 4D supergravity theories. The correspondence of geometry with structure in the low-energy action illuminates topological aspects of heterotic-F-theory duality in 4D as well as in 6D. The existence of an F-theory realization also places geometrical constraints on the 4D supergravity theory in the large-volume limit.Comment: 63 page

АНТИГЕЛЬМИНТНАЯ ЭФФЕКТИВНОСТЬ НОВЫХ ЛЕКАРСТВЕННЫХ ФОРМ ФЕНАСАЛА НА ОСНОВЕ СУПРАМОЛЕКУЛЯРНЫХ, НАНОРАЗМЕРНЫХ СИСТЕМ ДОСТАВКИ DRUG DELIVERY SYSTEM ПРИ АНОПЛОЦЕФАЛИДОЗАХ ЛОШАДЕЙ

Objective of research: Evaluation of efficacy of the new phenasal formulation based on supramolecular, nanoscale Drug Delivery Systems for anoplocephalidosis in horses. Materials and methods. Research was conducted on 60 horses, spontaneously infected with Anoplocephala spp. Animals were divided in 5 experimental and one control group, up to 10 heads in each. Horses from different groups received orally samples of supramolecular complex of phenasal with various polymers, including polyvinylpyrrolidone (PVP), arabinogalactan in the ratio 1: 2, and silicon dioxide in the ratio 1: 5 at a dose of 20 mg a. i. /kg. The basic preparation phenasal at a dose of 100 mg/kg was given to horses of the fifth group. Animals that did not receive the drug served as controls. The efficacy of preparations was estimated in control experiment according to the results of coproscopy using the flotation method before and 14 days after treatment. Results and discussion. 100 % efficacy of supramolecular complex of phenasal with arabinogalactan in the ratio 1: 2 at a dose of 20 mg a.i./kg and basic phenasal at a dose of 100 mg/kg was determined. Efficiency of phenasal complexes with PVP in the ratio 1: 2 and rabinogalactan in the ratio 1: 5 at a dose of 20 mg a.i./kg at a dose of 20 mg a.i./kg against anoplocephalidosis in horses was 87,2 and 80,1%, respectively.Цель исследования - изучение эффективности новых лекарственных форм фенасала на основе супрамолекулярных наноразмерных систем доставки Drug Delivery System при аноплоцефалидозах лошадей. Материалы и методы. Исследования проводили на 60 лошадях, спонтанно инвазированных аноплоцефалидами. Животных разделили на 5 подопытных и одну контрольную группы по 10 голов в каждой. Лошадям разных групп перорально задавали образцы супрамолекулярных комплексов фенасала с различными полимерами, в том числе с поливинилпирролидоном (ПВП), арабиногалактаном в соотношении 1 : 2, кремнеземом в соотношении 1 : 5 в дозе 20 мг/кг по ДВ. Базовый препарат фенасал в дозе 100 мг/кг назначали лошадям пятой группы. Контролем служили животные, не получавшие препарат. Эффективность препаратов учитывали по результатам копроовоскопии методом флотации до и через 14 сут после лечения в опыте типа «контрольный тест». Результаты и обсуждение. Получена 100%-ная эффективность супрамолекулярного комплекса фенасала с арабиногалактаном в соотношении 1 : 2 в дозе 20 мг/кг по ДВ и базового препарата - фенасала в дозе 100 мг/кг. Эффективность комплексов фенасала с ПВП в соотношении 1 : 2 и с арабиногалактаном в соотношении 1 : 5 в дозе 20 мг/кг по ДВ в дозе 20 мг/кг по ДВ составила при аноплоцефалидозах лошадей соответственно 87,2 и 80,1 %