8 research outputs found
Enhanced optoelectronic quality of perovskite thin films with hypophosphorous acid for planar heterojunction solar cells
Solution-processed metal halide perovskite semiconductors, such as CH3NH3PbI3, have
exhibited remarkable performance in solar cells, despite having non-negligible density of
defect states. A likely candidate is halide vacancies within the perovskite crystals, or the
presence of metallic lead, both generated due to the imbalanced I/Pb stoichiometry which
could evolve during crystallization. Herein, we show that the addition of hypophosphorous
acid (HPA) in the precursor solution can significantly improve the film quality, both
electronically and topologically, and enhance the photoluminescence intensity, which leads to
more efficient and reproducible photovoltaic devices. We demonstrate that the HPA can
reduce the oxidized I2 back into I�, and our results indicate that this facilitates an improved
stoichiometry in the perovskite crystal and a reduced density of metallic lead
Effect of Glycyrrhizic Acid on Gonadotropins, Estradiol, Testosterone and Inflammatory Cytokines in Polycystic Ovarian Syndrome Rat Model
Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders and most important cause of anovulation. High levels of inflammatory cytokines cause deterioration of polycystic ovary syndrome. Glycyrrhizic acid is the most important saponins from licorice. Considering the hypoandrogenic and antioxidant properties of licorice, aim of this study was to determine the effect of glycyrrhizic acid on gonadotropins, estradiol, testosterone and inflammatory cytokines in polycystic ovarian syndrome rat model.
Methods: In this experimental study, 32 wistar female rats were divided into 4 equal groups of control (saline solution, 24 days, ip), PCOS control (saline solution, 24 days, ip) and two PCOS groups under treatment with glycyrrhizic (25 and 50 mg/kg, 24 days, ip). Polycystic ovarian syndrome was induced by single intramuscular injection of estradiol valerate (4 mg/kg). At the end of treatment period, serum levels of TNF-α, IL-1β, IL-6, LH, FSH, estradiol and testosterone were measured using ELISA. Data were analyzed using one-way ANOVA and Post Hoc Tukey statistical tests (p<0.05).
Results: Compared to the PCOS control group, serum levels of LH, estradiol, testosterone, TNF-α, IL-1β and IL-6 in treated groups with 25 and 50 mg/kg glycyrrhizic acid dose-dependent significantly decreased. Also, serum level of FSH dose-dependent significantly increased (p<0.05).
Conclusion: Glycyrrhizic Acid by decreases serum levels of inflammatory cytokines has favorable effect on improving hormonal parameters in rats with polycystic ovary syndrome