Complexes of Some Transition Metal with 2-Benzoyl thiobenzimidazole and 1,10-Phenanthroline and Studying their Antibacterial Activity

Mixed ligands of 2-benzoyl Thiobenzimiazole (L1) with 1,10-phenanthroline (L2) complexes of Cr(III) , Ni(II) and Cu(II) ions were prepared. The ligand and the complexes were isolated and characterized in solid state by using FT-IR, UV-Vis spectroscopy, 1H, 13C-NMR, flame atomic absorption, elemental micro analysis C.H.N.S, magnetic susceptibility , melting points and conductivity measurements. 2-Benzoyl thiobenzimiazole behaves as bidenetate through oxygen atom of carbonyl group and nitrogen atom of imine group. From the analyses Octahedral geometry was suggested for all prepared complexes. A theoretical treatment of ligands and their metal complexes in gas phase were studied using HyperChem-8 program, moreover, ligands in gas phase also has been studied using Gaussian program (GaussView Currently Available Version (5.0.9) along with Gaussian 09 which was the latest in the Gaussian series of programs). The antibacterial activity of the prepared complexes have been determined and compared with that of the ligand and the standard metronidazole

Synthesis, Spectral Identification, Antibacterial Evaluationand Theoretical Study of Co, Fe, Rh and Pd Complexes for 2-benzoylthiobenzimidazol

      تم تحضير سلسلة جديدة لمعقدات بعض الايونات الفلزيه من خلال تفاعل ليكاند 2-بنزويل ثايوبنزامايدزول مع أملاح الفلزات للكوبلت  (II) ، الحديد (III) والروديو(II) ، أما معقد البلاديوم (II) تم تحضيره من خلال مزج 2-بنزويل ثايوامايدزولكليكاند أساسي و البابريدينكليكاند ثانوي مع كلورد البلاديوم كملح الفلز في وسط من الأيثانول. تم تشخيص الأشكال لهذه المركبات بواسطة التحليل الدقيق للعناصر، طيف الاشعه فوق البنفسجيه ،تقنية طيف الاشعه تحت الحمراء، الحساسية المغناطيسية، التوصيلية المولارية وتقنية الامتصاص الذري اللهبي. من خلال النتائج التي تم الحصول عليها من التحاليل الطيفية  تم اقتراح الشكل الثماني السطوح لمعقدي  الحديد والروديوم والشكل المربع المستوي لمعقد البلاديوم  ورباعي السطوح لمعقد الكوبلت.اظهرت جميع المعقدات المحضرة استقرارا واضحا ويمكن تخزينها لعدة أشهر دون أي تغيير ملموس . تم أستخدام الطرق شبة التجريبية ZINDO/ 1)  ،ZINDO/S & PM3) لحساب حرارة التكوين ∆H˚f ، وطاقة الاتباط∆Eb ، والعزم ثنائي القطب لجميع المركبات كدراسة نظرية . أظهرت المعقدات نشاط بايولوجي ملحوظ تجاة البكتيريا المسببه للامراض عند أخنبارها على انواع مختارة من البكتيريا . أظهرت المركبات المحضرة نشاطأ مضادأ للبكتيريا متوسطأ وجيد جدا ضد السلالات البكتيرية  . مثلE-scherichia coli،Staphylococcus aureusوPseudomonas aeruginosa.A new novel series of metalcomplexes are prepared from reactions between 2-benzoylthio- benzimidazole (L) with metal salts of Co (II) , Fe(III) and Rh (III) , while Pd(II) complex was obtained by mixing ligandsof 2-benzoylthiobenzimidazole (L) as primary ligand and bipyridine (L/)as secondary ligand as well as palladium chloride as metal salt in an ethanoic medium. The geometry of these compounds were identified using C.H.N.microanalysis, Ultraviolet–visible, Fourier transforms infrared, magnetic susceptibility, molar conductivity and flame atomic absorption (A.A). From the dataobtained by these spectral analyses, the molecular structures for Rh and Fe complexes were proposed to be octahedral geometry. A square planar construction is proposed for Pd(II), while a Tetrahedral Geometry for Cobalt (II)complex. All of the complexes which were prepared displayedobviousconstancy and could be stored for months without showing any considerablealteration. Semi-empirical methods (ZINDO/1, ZINDO/S & PM3) were conducted to assess the heat of formation ∆H˚f, binding energy ∆Eb, and dipole moment for all compounds as theoretic study. The complexes expressnotable biological activities to pathogenic bacteria when inspected on certain bacteria. The synthesized compounds exhibited moderate toverygood antibacterial activity against bacterial strains, i.e., Escherichiacoli, Staphylococcus aureus & Pseudomonas aeruginosa

Synthesis, Characterization of Derivatives Tetrazoles for Trimethoprim Drug

The present work involved synthesis of serval new substituted tetrazole via Schiff bases for trimethoprim drug by two steps. The first step involved direct reaction of different ketones and aldehydes with trimethoprim producing the corresponding Schiff bases (1-10), whereas the second step, involved preparation new tetrazoles derivatives (11-20) through reaction of the ready Schiff bases (in the first step) with sodium azidein in dioxin. The prepared compounds were characterized by UV, FT-IR, and some of them by 13C-NMR, 1H-NMR spectroscopy and physical properties

Loop based scheduling for high level synthesis

This paper describes a new loop based scheduling algorithm. The algorithm aims at reducing the runtime processing complexity of path based scheduling techniques. It partitions the control flow graph of the input specification into subgraphs before scheduling the different paths of each subgraph. Benchmark tests as well as simulation results on the scheduling algorithm indicate that the proposed algorithm results in sizeable reduction in runtime

Klippel-Trénaunay Syndrome with Intracranial Arteriovenous Malformation: A Rare Presentation

Klippel-Trénaunay syndrome (KTS) is a rare vascular congenital anomaly affecting less than 200,000 people in the United States. Vascular malformations associated with KTS tend to affect slow flow systems: venous, capillary, and lymphatic systems. The nature of the syndrome leads to a higher risk for the development of arteriovenous malformations. Our case presentation describes a patient with KTS and an associated rare presentation of intraventricular arteriovenous malformation (AVM)

Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats

Derailment-based fault tree analysis on risk management of railway turnout systems

Railway turnouts are fundamental mechanical infrastructures, which allow a rolling stock to divert one direction to another. As those are of a large number of engineering subsystems, e.g. track, signalling, earthworks, these particular sub-systems are expected to induce high potential through various kind of failure mechanisms. This could be a cause of any catastrophic event. A derailment, one of undesirable events in railway operation, often results, albeit rare occurs, in damaging to rolling stock, railway infrastructure and disrupt service, and has the potential to cause casualties and even loss of lives. As a result, it is quite significant that a well-designed risk analysis is performed to create awareness of hazards and to identify what parts of the systems may be at risk. This study will focus on all types of environment based failures as a result of numerous contributing factors noted officially as accident reports. This risk analysis is designed to help industry to minimise the occurrence of accidents at railway turnouts. The methodology of the study relies on accurate assessment of derailment likelihood, and is based on statistical multiple factors-integrated accident rate analysis. The study is prepared in the way of establishing product risks and faults, and showing the impact of potential process by Boolean algebra

Natalizumab affects T-cell phenotype in multiple sclerosis: implications for JCV reactivation

The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV) and development of progressive multifocal leukoencephalopathy (PML). To correlate natalizumab-induced phenotypic modifications of peripheral blood T-lymphocytes with JCV reactivation, JCV-specific antibodies (serum), JCV-DNA (blood and urine), CD49d expression and relative abundance of peripheral blood T-lymphocyte subsets were longitudinally assessed in 26 natalizumab-treated RRMS patients. Statistical analyses were performed using GraphPad Prism and R. Natalizumab treatment reduced CD49d expression on memory and effector subsets of peripheral blood T-lymphocytes. Moreover, accumulation of peripheral blood CD8+ memory and effector cells was observed after 12 and 24 months of treatment. CD4+ and CD8+ T-lymphocyte immune-activation was increased after 24 months of treatment. Higher percentages of CD8+ effectors were observed in subjects with detectable JCV-DNA. Natalizumab reduces CD49d expression on CD8+ T-lymphocyte memory and effector subsets, limiting their migration to the central nervous system and determining their accumulation in peripheral blood. Impairment of central nervous system immune surveillance and reactivation of latent JCV, can explain the increased risk of PML development in natalizumab-treated RRMS subjects