Current status of myocardial perfusion imaging radiopharmaceuticals for SPECT and PET imaging modalities

Coronary artery disease (CAD) is the leading cause of death and remains a major health problem worldwide. Myocardial perfusion imaging (MPI) with single photon emission tomography (SPECT) and positron emission tomography (PET) has been established as the main functional nuclear cardiology noninvasive technique for CAD over the past years. The studies has been shown that the use of MPI as a useful and important imaging modality for the diagnosis, risk stratification and treatment planning for CAD. The purpose of this article is to review properties of the radiopharmaceuticals used for myocardial perfusion imaging with SPECT and PET

An incidental detection of aortic aneurysm on Tc-99m MAG3 renal scintigraphy

A 71-year-old man with newly diagnosed hypertension was referred for Technetium-99m mercaptoacetyltriglycine (Tc-99mMAG3) renal scintigraphy to evaluate the recent onset of impairmentin renal functions. Dynamic imaging revealed activity flowwhich was suspicious for aortic aneurysm (AA) with a concurrent decrease in left renal blood flow. CT angiography of the thoracoabdominal aorta confirmed that this area corresponded to AA. The purpose of this report was to present the first case of incidental detection of AA on Tc-99m MAG3 scintigraphy and highlight the importance of correlative imaging for thediagnosis of abnormal radioactivity accumulation in the regionof vascular structures

Can Tc-99m labeled erythrocyte scintigraphy be an alternative non-invasive method to endometriosis diagnosis?

Background: Endometriosis is defined as the implantation of endometrial gland and stroma ectopically outside the uterus. Clinically, it is a hormone dependent benign disease accompanied by pelvic pain and infertility. The aim of this study was to demonstrate the activated implants with 99m-Tc labeled erythrocyte scintigraphy (99mTc-RBCs) in patients with recurrent endometriosis and compare the results with pelvic MRI results.Methods: Patients who were diagnosed histopathologically as endometriosis either with operation and / or therapeutic laparascopy or laparotomy and, were included to present study. Thirty patients, who were diagnosed as recurrence by clinical, and laboratory terms and 10 healthy volunteer (control group) patients were included in the study. Between the second and fifth days of menstruation when the endometriotic lesions were highly activated, radionuclide imaging was performed by 99mTc-RBCs and compared with pelvic MRI findings.Results: In 27 patients out of 30 patients (90%) pathological accumulation of radioactivity foci with 99mTc-RBCs were present. The focal pathological accumulation was significant in 26 patients and moderate in 1 patient. In 22 patients (81.5%) the increased radioactivity accumulation in radionuclide images was concordant with MRI images. Regarding the MRI as reference, the sensitivity of 99mTc-RBCs was determined as 96%, specificity 29%, positive predicitive value 81% and negative predictive value was 66%.Conclusions: Imaging of endometriosis regions with 99m-Tc-RBCs can be an alternative diagnostic procedure for the patients with recurrent endometriosis

Current status of myocardial perfusion imaging radiopharmaceuticals for SPECT and PET imaging modalities

Coronary artery disease (CAD) is the leading cause of death and remains a major health problem worldwide. Myocardial perfusion imaging (MPI) with single photon emission tomography (SPECT) and positron emission tomography (PET) has been established as the main functional nuclear cardiology noninvasive technique for CAD over the past years. The studies has been shown that the use of MPI as a useful and important imaging modality for the diagnosis, risk stratification and treatment planning for CAD. The purpose of this article is to review properties of the radiopharmaceuticals used for myocardial perfusion imaging with SPECT and PET

Effect of amifostine on sperm DNA fragmentation and testes after radioiodine treatment

Introduction: Radioactive iodine (RAI) is commonly used for the treatment of hyperthyroidism caused by Graves’ disease or thyroid nodules. However, information available on the impact of RAI therapy on male gonadal function is scarce. This study aimed to determine any possible damage to testicular tissue and sperm quality caused by RAI therapy, and the radioprotective effect of amifostine against such damage