Fetal Pain, Abortion, Viability and the Constitution

In early 2010, the Nebraska state legislature passed a new abortion restricting law asserting a new, compelling state interest in preventing fetal pain. In this article, we review existing constitutional abortion doctrine and note difficulties presented by persistent legal attention to a socially derived viability construct. We then offer a substantive biological, ethical, and legal critique of the new fetal pain rationale

Response ofCapsicum annum to two VAM species under green house condition

Pot trial experiments were conducted under green house condition to study the response of Capsicum annum (Chilli) to the inoculation of two species of Glomus fungi. Response of chilli in terms of growth and biochemical components were recorded. Experiments conducted by inoculating the Glomus fasciculatum, G. mossae, Nitrogen(N) Phosphorus(P) Potassium(K) and uninoculated control in four replicates. Chilli showed improved performance than un-inoculated one. The growth parameters, number of fruits, weight of the plant, number of branches, size of the plant, number of flowers and biochemical concentration viz. carbohydrates, proteins and reducing sugars was significantly higher in G. fasciculatum and G. mossae compared to NPK treated, while un-inoculated control showed least performance among the experimental sets. Significant gain in growth parameters and biochemical composition was recorded

Characterization of Isolated Bioactive Phytoconstituents from Flacourtia Indica as Potential Phytopharmaceuticals-An in Silico Perspective

The dependence of mankind for therapeutic applications on plants dates back to the start of the human race. Natural remedies from ethnobotanicals are found to be safe and cost effective. Due to the poor pharmacokinetic profiles and toxicity problems many synthetic drugs often fails to enter the market thus, the pharmacologically active compounds from plants continued to provide an important source of novel drug leads. The early inclusion of pharmacokinetics consideration in the drug discovery process using in silico methods is becoming popular due to improved generation of software’s. The problems with conventional method required time-consuming multi-step processes against a battery of in vivo biological screening and high cost thus, In silico prediction of the pharmacokinetic parameters, biological properties and toxicity due to advent of chemo-informatics tools, has reduced the cost dramatically and early application in drug design are realized. The present investigation deals with computational evaluation of six isolated phytocompounds from Flacourtia indica for their pharmacological potential and biological activities. These compounds were evaluated for drug likeness properties, bioactivity score, ADME/T profiles, and health affects by using various bioinformatics tools. The result indicated that all the six compounds analyzed were non mutagens, non-carcinogens and having good drug-likeness properties were seen. The ADMET parameters and probability of health effects were analyzed by admet SAR and ACD/I-Lab online tools respectively and results shows the ADMET and probability of health effects values are also in satisfying ranges. Pharmacological activities of these compounds were predicted individually using PASS server many different pharmacological activities and mechanisms of action shown by these compounds were reported. The results of our analysis clearly depict that all six phytocompounds were having good pharmacokinetic profiles with numerous biological activities. These compounds can be further studied in vitro and in vivo for the discovery of novel preventive and therapeutic drug

Psychosocial adversities in women substance dependence: A case report

Until recently, psychoactive substance use perceived as a male phenomenon. Although men out-rate woman in prevalence of substance use, women are at greater risk for its adverse effects.[1] Gender status influence many aspects of substance use/dependence. Women substance use associated with psychiatric co-morbidity especially depression and anxiety disorder, while men substance use is related with more externalizing spectrum disorders such as antisocial personality.[2-4] Many studies demonstrated that women suffer substantially higher health complications[5] and psychosocial adversities[6] related to substance dependence. Psychosocial factors influencing to the initiation, continuation and outcome of substance use in women

APPLICATION OF MOLECULAR SALT FORMATION REACTIONS OF PICRIC ACID AND CITRIC ACID -ACETIC ANHYDRATE SYSTEM WITH CINITAPRIDE TARTRATE FOR ESTIMATION OF THE DRUG IN BULK AND PHARMACEUTICAL FORMULATIONS

Objective: The present investigation was aimed at developing and validating two novel highly sensitive, selective, accurate and simple spectrophotometric methods for the determination of Cinitapride tartrate (CNP) in bulk and its dosage forms Methods: Method A was based on molecular salt formation reaction of Cinitapride tartrate with Picric Acid to form a yellow coloured chromogen having absorption maxima of 410 nm*. Method B was based on the formation of an internal salt between Cinitapride tartrate and citric acid –acetic anhydrate system that was measured at 565 nm*. The factors affecting the reaction in both the methods were carefully studied and optimized. The kinetics of the reaction was investigated, and the reaction mechanism was postulated. Results: Under the optimized conditions, linear relationship with good correlation coefficient of was found between the absorbance and Cinitapride tartrate concentration in the range of 8-40 μg / mL and 4-20μg / mL for method A and B respectively. The precision of the method was satisfactory; the values of relative standard deviations did not exceed 1.4%. The proposed method was successfully applied to the determination of Cinitapride tartrate in its bulk form and pharmaceutical formulations with good accuracy. Conclusion: The proposed method was successfully applied to the determination of Cinitapride tartrate in its bulk form and pharmaceutical formulations with good accuracy. Hence, these methods can be used for the routine quality control of CNP in its dosage forms