161 research outputs found
Direct Observation of Dimerization between Different CREB1 Isoforms in a Living Cell
Cyclic AMP-responsive element binding protein 1 (CREB1) plays multiple functions as a transcription factor in gene regulation. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors. The activator isoforms, possessing the functional domains for kinase induction and for interaction with other transcriptional regulators, act as transcriptional activators. On the other hand, some isoforms, lacking those functional domains, are reported to be repressors that make heterodimers with activator isoforms. The complex and ingenious function for CREB1 arises in part from the variation in their spliced isoforms, which allows them to interact with each other. To date, however, the dimerization between the activator and repressor isoforms has not yet been proved directly in living cells. In this study, we applied fluorescence cross-correlation spectroscopy (FCCS) to demonstrate direct observation of dimerization between CREB1 activator and repressor. The FCCS is a well established spectroscopic method to determine the interaction between the different fluorescent molecules in the aqueous condition. Using differently labeled CREB1 isoforms, we successfully observed the interaction of CREB1 activator and repressor via dimerization in the nuclei of cultured cells. As a result, we confirmed the formation of heterodimer between CREB1 activator and repressor isoforms in living cells
Unicentric Castleman's disease approached as a pancreatic neoplasm: case report and review of literature
Castleman's disease is a rare lymphoproliferative disorder. Most cases occur in the mediastinum and the pancreatic localization is uncommon; currently there are only nine reported cases in the literature about peripancreatic localization. We report a case of a 62 years old man with a Castleman's disease mimicking a pancreatic neoplasm
Search for Light Gluinos via the Spontaneous Appearance of pi+pi- Pairs with an 800 GeV/c Proton Beam at Fermilab
We searched for the appearance of pi+pi- pairs with invariant mass greater
than 648 MeV in a neutral beam. Such an observation could signify the decay of
a long-lived light neutral particle. We find no evidence for this decay. Our
null result severely constrains the existence of an R0 hadron, which is the
lightest bound state of a gluon and a light gluino, and thereby also the
possibility of a light gluino. Depending on the photino mass, we exclude the R0
in the mass and lifetime ranges of 1.2 -- 4.6 GeV and 2E-10 -- 7E-4 seconds,
respectively. (To Appear in Phys. Rev. Lett.)Comment: Documentstyle aps,epsfig,prl (revtex), 6 pages, 7 figure
Search for the Decay K_L -> pi^0 nu nubar using pi^0 -> e^+ e^- gamma
We report on a search for the decay K_L -> pi^0 nu nubar, carried out as a
part of E799-II, a rare K_L decay experiment at Fermilab. Within the Standard
Model, the K_L -> pi^0 nu nubar decay is dominated by direct CP violating
processes, and thus an observation of the decay implies confirmation of direct
CP violation. Due to theoretically clean calculations, a measurement of B(K_L
-> pi^0 nu nubar) is one of the best ways to determine the CKM parameter eta.
No events were observed, and we set an upper limit B(K_L -> pi^0 nu nubar) <
5.9 times 10^-7 at the 90% confidence level.Comment: 5 pages, 4 figure
Search for the Decay
We report on a search for the decay \klpimumu carried out as a part of the
KTeV experiment at Fermilab. This decay is expected to have a significant
violating contribution and a direct measurement will either support the CKM
mechanism for CP violation or point to new physics. Two events were observed in
the 1997 data with an expected background of events, and we set
an upper limit \BR{\klpimumu} at the 90% confidence
level.Comment: See also "Observation of the Decay ", also by the KTeV collaboratio
Observation of the Decay
We have observed the decay at the KTeV
experiment at Fermilab. This decay presents a formidable background to the
search for new physics in . The 1997 data yielded a
sample of 4 signal events, with an expected background of 0.155 0.081
events. The branching ratio is )
with
, consistent with a QED calculation
which predicts .Comment: See also the paper "Search for the Decay ", also by the KTeV collaboratio
A Measurement of the KL Charge Asymmetry
We present a measurement of the charge asymmetry in the mode based on 298 million analyzed decays. We measure a
value of , in good
agreement with previous measurements and 2.4 times more precise than the
current best published result. The result is used to place more stringent
limits on CPT and violation in the neutral kaon system.Comment: Submitted to Physical Review Letters, Dec 31, 2001. 4 pages, 4
figure
Search for the Decay Kl -> pi0 e+ e-
We report on a search for the decay Kl -> pi0 e+ e- carried out by the
KTeV/E799 experiment at Fermilab. This decay is expected to have a significant
CP violating contribution and the measurement of its branching ratio could
support the CKM mechanism for CP violation or could point to new physics. Two
events were observed in the 1997 data with an expected background of 1.06
+-0.41 events, and we set an upper limit Br(Kl -> pi0 e+ e-) < 5.1 x 10^-10 at
the 90% confidence level.Comment: 13 pages, 2 figure
Measurement of the Decay KL -> Pi0 Gamma Gamma
We report on a new measurement of the decay KL -> pi0 gamma gamma by the KTeV
experiment at Fermilab. We determine the KL -> pi0 gamma gamma branching ratio
to be (1.68 +/- 0.07 +/- 0.08)x10**-6. Our data shows the first evidence for a
low-mass gamma gamma signal as predicted by recent O(p**6) chiral perturbation
calculations that include vector meson exchange contributions. From our data,
we extract a value for the effective vector coupling aV = -0.72 +/- 0.05 +/-
0.06.Comment: 5 pages, 4 figure
Observation of CP Violation in K(L)->pi+pi-e+e- Decays
We report the first observation of a manifestly CP violating effect in the
K(L)->pi+pi-e+e- decay mode. A large asymmetry was observed in the distribution
of these decays in the CP-odd and T-odd angle phi between the decay planes of
the e+e- and pi+pi- pairs in the K(L) center of mass system. After acceptance
corrections, the overall asymmetry is found to be 13.6+-2.5 (stat) +-1.2
(syst)%. This is the largest CP-violating effect yet observed integrating over
the entire phase space of a mode and the first such effect observed in an
angular variable.Comment: 4 pages 4 figures submitted to pr
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