PFO size estimation using TCD: Are the measurements gender related?

There is an ongoing interest in using the findings of Transcranial Doppler (TCD) as a diagnostic technique for patent foramen ovale (PFO) determination. The aim of this study was to investigate the sensitivity of TCD for detection of PFO presence and the correlation of PFO size with the detected microbubble signals. The study group comprised of 103 individuals, healthy volunteers and patients with ischemic stroke or other cerebrovascular diseases. TCD was performed on all subjects, while the presence and size of PFO was estimated with Transesophageal Echocardiography (TEE). PFO diagnosis with TCD had a 92.68% sensibility, 89.47% specificity, 86.65% positive predictive value and 94.44% negative predictive value. PFO size was moderately correlated with the number of microembolic signals detected (rs = 0.404, p = 0.026). Further analysis for gender shown a strong correlation for men (rs = 0.781, p = 0.003), but no correlation for women (p = 0.92). Our results show that TCD is a good predictor of PFO in terms of sensibility and specificity. The correlation between the size of PFO on TEE and the number of microembolic signals detected on TCD is gender biased. Further anatomic and physiological studies are required to identify the reasons for this phenomenon

Drug Eluding Stents for Malignant Airway Obstruction: A Critical Review of the Literature

Lung cancer being the most prevalent malignancy in men and the 3rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement

Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature

Lung cancer being the most prevalent malignancy in men and the 3(rd) most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement