SL(2,2f)における組合せ論

取得学位：博士(理学)，学位授与番号：博甲第505号，学位授与年月日：平成14年3月22日,学位授与年：200

The Effect of Long-Running Severe Selenium-Deficiency on the Amount of Iron and Zinc in the Organs of Rats

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The effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats

The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measrued using instrumental neutron activation analysis were compared between Se-deficinet (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. THe effect of Se-deficiency in rats mitht be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considred as a model of non-lethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats wre observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat oragans is changeable depending on the age

Feeding period of selenium-deficient diet and response of redox relating minerals

Dynamics of redox relating biotrace elements, selenium (Se), iron (Fe), and zinc (Zn) in liver, kidney, and spleen of selenium deficient Wistar male rats in a series of feeding period (from 0 to 8 weeks) were studied using instrumental neutron activation analysis (INAA). AST, ALT, and BUN for the plasma fraction of the rat bloods and the concentration of vitamin C and vitamin E in the liver homogenates were measured. The initial purpose of this study was to find Fe and Zn as sensitive indices of the tissue oxidative stress levels. However, the relationships among the biotrace elements and the oxidative stress/injury were much complicated. Control group, which was fed Se-deficient diet with Na2SeO4 (0.1 mg selenium/L) in drinking water, showed strange response of Se and Zn contents in the kidney and showed high BUN. Supplementation of inorganic Se by biased Se source may serve as another source of a stress especially in the kidney. The Fe and Zn contents in the liver and kidney look sensitive to the Se-deficiency and/or relating oxidative stresses. Short term exposure to the Se-deficiency appeared to consume Fe and Zn in the liver and kidney. In contrast, long term or chronic exposure to Se-deficiency appeared to accumulate Fe and Zn in liver and kidney