Density Wave -Supersolid and Mott Insulator-Superfluid transition in presence of an artificial gauge field : a strong coupling perturbation approach

We study the effect of an artificial gauge field on the zero temperature phase diagram of extended Bose Hubbard model, that describes ultra cold atoms in optical lattices with long range interaction using strong coupling perturbation theory . We determine analytically the effect of the artificial gauge field on the density wave - supersolid (DW-SS) and the the Mott insulator-superfluid (MI -SF) transition boundary . The momentum distribution at these two transition boundaries is also calculated in this approach. It is shown that such momentum distribution which can be observed in time of flight measurement, reveals the symmetry of the gauge potential through the formation of magnetic Brillouin zone and clearly distinguishes between the DW-SS and MI-SF boundary. We also point out that in symmetric gauge the momentum distribution structure at these transition boundaries bears distinctive signatures of vortices in supersolid and superfluid phases.Comment: 18 latexed two column pages including appendix, 9 .eps figures Figure positioning readjusted and one reference adde

Adapting the queen square guided self help (QGSH) for functional neurological disorders as a stand-alone intervention: an exonian pilot study

Aim: Functional neurological disorders (FND) are one of the most common presentation in neurology clinics, causing a significant disability and economic burden. Cognitive behavioural therapy (CBT) has one of the best available evidence in managing FND, although access remains limited. Queen Square, London neuropsychiatry experts have established an excellent model for a CBT based, Guided Self Help (GSH) programme, which is preparatory to a multidisciplinary inpatient treatment. It has been shown to have good outcomes. This study was designed to ascertain the feasibility and acceptance of this QGSH model, in an Exonian cohort of FND patients, whilst piloting its stand-alone version, without the inpatient component. Additionally, the study explores the need and types of modifications required for the stand-alone adaptation of QGSH. Method: Consecutive patients referred to Exeter FND Service, between February to June 2020, who had internet access, were offered the QGSH pilot. Patients with a primary mental disorder concurrent drug/alcohol misuse or risk of self-harm or suicide were excluded. Ethics approval was not required. The QGSH intervention constitutes of 11 modules focussing on specific elements crucial to FND management along with homework tasks, delivered by the author, under supervision by QGSH experts. Patients completed Pre and Post-intervention questionnaires as well as structured feedback. Results: Three successive patients with varied FND symptoms were recruited to the pilot between February and June 2020. The baseline health status of these patients was worse as compared to EQ-5D-5L population norms with significant baseline psychiatric comorbidity. Outcome measures used before and after QGSH intervention included PHQ 9, GAD 7, EQ-5D-5L and a locally devised symptom severity questionnaire. Necessary modifications were made to the program based on the patients informal feedback and structured formal feedback was sought in the end. Conclusion: All patients derived some benefit from QGSH and certain modifications were suggested in patient feedback to improve engagement. Despite study limitations, especially small size and the impact of Covid 19 pandemic during the intervention; QGSH model appears acceptable and feasible in an Exonian cohort, however, some modifications are recommended for the stand-alone version to succeed. The recommendations will be presented

Zinc-Catalyzed Guanylation Reaction of Amines to Carbodiimides/Isocyanate Leading to of Guanidines/Urea Derivatives Formation

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An investigation of the saving-enhanced memory effect: The role of test order and list saving

Saving information onto external resources can improve memory for subsequent information—a phenomenon known as the saving-enhanced memory effect. This article reports two preregistered online experiments investigating (A) whether this effect holds when to-be-remembered information is presented before the saved information and (B) whether people choose the most advantageous strategy when given free choice of which information to save. Participants studied two lists of words; test order and whether and which list was saved (and re-presented again later) were manipulated. The saving-enhanced memory effect was only found when the first list (List A) was saved and tested after the second list (List B). When free to choose which list to save, participants preferred to save List A, but only when it was recalled after List B—that is, when it benefited memory. These findings suggest boundary conditions for the saving-enhanced memory effect and that people offload the most profitable information

Outsourcing Memory to External Tools: A Review of 'Intention Offloading'

How do we remember delayed intentions? Three decades of research into prospective memory have provided insight into the cognitive and neural mechanisms involved in this form of memory. However, we depend on more than just our brains to remember intentions. We also use external props and tools such as calendars and diaries, strategically placed objects, and technologies such as smartphone alerts. This is known as 'intention offloading'. Despite the progress in our understanding of brain-based prospective memory, we know much less about the role of intention offloading in individuals' ability to fulfil delayed intentions. Here, we review recent research into intention offloading, with a particular focus on how individuals decide between storing intentions in internal memory versus external reminders. We also review studies investigating how intention offloading changes across the lifespan and how it relates to underlying brain mechanisms. We conclude that intention offloading is highly effective, experimentally tractable, and guided by metacognitive processes. Individuals have systematic biases in their offloading strategies that are stable over time. Evidence also suggests that individual differences and developmental changes in offloading strategies are driven at least in part by metacognitive processes. Therefore, metacognitive interventions could play an important role in promoting individuals' adaptive use of cognitive tools

Evaluating variation in use of definitive therapy and risk-adjusted prostate cancer mortality in England and the USA.

OBJECTIVES: Prostate cancer mortality (PCM) in the USA is among the lowest in the world, whereas PCM in England is among the highest in Europe. This paper aims to assess the association of variation in use of definitive therapy on risk-adjusted PCM in England as compared with the USA. DESIGN: Observational study. SETTING: Cancer registry data from England and the USA. PARTICIPANTS: Men diagnosed with non-metastatic prostate cancer (PCa) in England and the USA between 2004 and 2008. OUTCOME MEASURES: Competing-risks survival analyses to estimate subhazard ratios (SHR) of PCM adjusted for age, ethnicity, year of diagnosis, Gleason score (GS) and clinical tumour (cT) stage. RESULTS: 222,163 men were eligible for inclusion. Compared with American patients, English patients were more likely to present at an older age (70-79 years: England 44.2%, USA 29.3%, p<0.001), with higher tumour stage (cT3-T4: England 25.1%, USA 8.6%, p<0.001) and higher GS (GS 8-10: England 20.7%, USA 11.2%, p<0.001). They were also less likely to receive definitive therapy (England 38%, USA 77%, p<0.001). English patients were more likely to die of PCa (SHR=1.9, 95% CI 1.7 to 2.0, p<0.001). However, this difference was no longer statistically significant when also adjusted for use of definitive therapy (SHR=1.0, 95% CI 1.0 to 1.1, p=0.3). CONCLUSIONS: Risk-adjusted PCM is significantly higher in England compared with the USA. This difference may be explained by less frequent use of definitive therapy in England