Phyto-chemical evaluation of ethanomedicinal herb jawasaa

Alhagi pseudalhagi (Bieb) Desv. (Leguminosae) is widely distributed in Semi-arid zone of India. A.pseudalhagi is one of the most widely used medicinal plants for the treatment of various diseases in different rural and remote areas of district Etah in UP, India. Alhagi is rich in biologically active phyto-chemicals such as phenolics, flavonoids, alkaloids and polysaccharides along with different essential minerals, proteins and lipids. Alhagi plants are widely used as folk medicines to treat a large number of diseases of which a few are the following: gastroenteritis, diarrhea, ulcers, liver disorders, fever, hypertension, angina pain, headache and toothache, inflammations, rheumatoid arthritis, renal stone and urinary tract infections. The study includes preparation of different extract by successive solvent extraction for detail analysis. Fluorescence analysis of different successive extract and powder were noted under UV (366nm) and ordinary light, which signifies their characteristic. Preliminary qualitative chemical test for different extract showed presence of alkaloids, carbohydrates and glycosides, flavonoids, tannins, phenolic compounds, fixed oils and fats, protein and amino acids, steroids and terpenoids

High Prevalence of Associated Birth Defects in Congenital Hypothyroidism

Aim. To identify dysmorphic features and cardiac, skeletal, and urogenital anomalies in patients with congenital hypothyroidism. Patients and Methods. Seventeen children with congenital primary hypothyroidism were recruited. Cause for congenital hypothyroidism was established using ultrasound of thyroid and 99mTc radionuclide thyroid scintigraphy. Malformations were identified by clinical examination, echocardiography, X-ray of lumbar spine, and ultrasonography of abdomen. Results. Ten (59%) patients (6 males and 4 females) had congenital malformations. Two had more than one congenital malformation (both spina bifida and ostium secundum atrial septal defect). Five (29%) had cardiac malformations, of whom three had only osteum secundum atrial septal defect (ASD), one had only patent ductus arteriosus (PDA), and one patient had both ASD and PDA. Seven patients (41%) had neural tube defects in the form of spina bifida occulta. Conclusion. Our study indicates the need for routine echocardiography in all patients with congenital hypothyroidism

Association of triglycerides/high density lipoprotein cholesterol ratio with insulin resistance in polycystic ovary syndrome

Background: Insulin resistance (IR) is frequently observed in women with polycystic ovary syndrome (PCOS). Recent studies advocated that triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) can be used as a simple clinical indicator of IR. Hence, the present study was performed to investigate the use of TG/HDL-C and its association with IR in PCOS.Methods: Forty-one patients with PCOS and 40 healthy age matched women were randomly enrolled. Demographic and clinical characteristics were obtained. Insulin resistance was defined by the homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI).Results: In PCOS group, the insulin, HOMA-IR and TG/HDL-C ratio were significantly higher (p=0.001) than controls while, QUICKI was lower (p=0.001). Insulin, HOMA-IR were positively correlated with TG/HDL-C (ρ=0.303, p=0.006 and ρ=0.312, p=0.005 respectively) while, QUICKI was negatively correlated (ρ=-0.698, p=0.001). In receiver operating characteristic (ROC) analysis, area under the curve (AUC) for model based on QUICKI levels was better 0.898 (95% CI: 0.811-0.955, p=0.001) than HOMA-IR 0.636 (95% CI: 0.522-0.740, p=0.03). A cut-off value 3.23 for TG/HDL-C is proposed from the model based on QUICKI with best combination of sensitivity 83.3% and specificity 86.7%.Conclusions: Results of present study support that TG/HDL-C ratio may be a simple indicator of IR in PCOS patients which helps clinicians to identify IR in small centers, where the assays for insulin measurement are not available

Essential organizational variables for the Implementation of Quality 4.0: Empirical evidence from the Indian furniture industry

Purpose-Quality 4.0 represents the integration of quality management principles with digital technologies to drive continuous improvement and innovation in organizations. The purpose of this paper is to explore the essential Organizational Variables (OVs) for the successful implementation of Quality 4.0 in the Indian furniture industry. Design/methodology/approach-Through a broad literature review, data from the Indian furniture industry, and experts’ judgments a list of nineteen OVs have been recognized and classified into four major categories of Digitalization, Design, Continuous Improvement, and Employee training and up-skilling. The analytic hierarchy process (AHP) has been used to give comparative importance and prioritize the identified nineteen OVs of Quality 4.0 in the context of the Indian furniture industry. Findings-The results of this study reveal that the identified variables are very important for successful Quality 4.0 implementation and have been supported by empirical evidence from the Indian furniture industry. The variable ‘Automation’ under the digitalization-related category is a significant variable having a maximum weightage of 26.8% followed by Cloud computing (DI4) having a global weight of 12.8%. Research limitations/implications-In addition to offering valuable insights and practical recommendations, the study recognizes a few limitations, such as industry-specific, and the limited sample size. To diminish these limitations, future research should believe in conducting similar studies in different industries and extend the scope of the study. Originality/value-Quality 4.0 is a term that refers to the integration of advanced digital technologies and smart data analytics into quality management systems to implement it considering organizational variables

Role of adipokines, oxidative stress, and endotoxins in the pathogenesis of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus

Background: Type 2 diabetes mellitus (T2DM) is associated with chronic inflammation and oxidative stress, implicated in the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Present study aimed to assess the role of adipokines, oxidative stress, and endotoxins in the pathogenesis of NAFLD in T2DM.Methods: Present cross-sectional observational study included healthy controls (n=50; group 1); T2DM patients without NAFLD (n=50; group 2), T2DM patients with NAFLD (n=50; group 3). Study subjects were age and gender matched.Results: Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high sensitive C-reactive protein (hs-CRP), endotoxin, malondialdehyde (MDA) were significantly elevated and adiponectin, ferric reducing ability of plasma (FRAP), and glutathione (GSH) were significantly lower (p<0.001) in T2DM patients with NAFLD when compared to T2DM patients without NAFLD and controls. Endotoxin showed significant positive correlation with TNF-α (r=0.304; p<0.001), hs-CRP (r=0.193; p=0.018), and MDA (r=0.420; p<0.001), and significant negative correlation with adiponectin (r=-0.406; p<0.001). TNF-α and IL-6 showed significant positive correlation with MDA (r=0.526; p<0.001, r=0.229; p=0.005) and significant negative correlation with adiponectin (r=-0.396; p<0.001, r=-0.318; p<0.001), FRAP (r=-0.418; p<00.001, r=-0.170; p=0.038), and GSH (r=-0.353; p<0.001, r=-0.301; p<0.001).Conclusions: Authors observed elevated endotoxin, oxidative stress, inflammation and lower adiponectin levels in T2DM subjects compared to controls. These changes were more pronounced in T2DM with NAFLD when compared to T2DM without NAFLD.  Lower adiponectin levels were found to be a better predictor of NALFD in T2DM and is associated with oxidative stress and systemic inflammation

Antiferromagnetic spin ladders effectively coupled by one-dimensional electron liquids

We study a model of the stripe state in strongly correlated systems consisting of an array of antiferromagnetic spin ladders, each with $n_{leg}$ legs, coupled to each other through the spin-exchange interaction to charged stripes in between each pair of ladders. The charged stripes are assumed to be Luttinger liquids in a spin-gap regime (Luther-Emery). An effective interaction for a pair of neighboring ladders is calculated by integrating out the gapped spin degree of freedom in the charged stripe. The low energy effective theory of each ladder is the usual nonlinear $\sigma$-model with additional cross couplings of neighboring ladders. These interactions are found to favor either in-phase or anti-phase short range spin orderings depending on whether the charge stripe is site-centered or bond-centered as well as on its filling factor and other physical parameters of the charged stripe.Comment: 4 pages with 1 figure, revised introduction and discussion section

Charge and Spin Dynamics of an Ordered Stripe Phase in La_(1 2/3)Sr_(1/3)NiO_4 by Raman Spectroscopy

For La_(1 2/3)Sr_(1/3)NiO_4 -- a commensurately doped Mott-Hubbard system -- charge- and spin-ordering in a stripe phase has been investigated by phononic and magnetic Raman scattering. Formation of a superlattice and an opening of a pseudo-gap in the electron-hole excitation spectra as well as two types of double-spin excitations -- within the antiferromagnetic domain and across the domain wall -- are observed below the charge-ordering transition. The temperature dependence suggests that the spin ordering is driven by charge ordering and that fluctuating stripes persist above the ordering transition.Comment: 5 pages, 4 EPS figures; to appear in Phys. Rev. Let

Response of sorghum to moisture stress using line source sprinkler irrigation I. Plant-water relations

The response of sorghum (Sorghum bicolor L.) to moisture stress during the post-rainy season was studied at ICRISAT research center on a medium deep Alfisol using a line source sprinkler irrigation system. Changes in soil moisture content, stomatal conductance, leaf-water potential and leaf temperature of sorghum as a function of distance away from the line source sprinkler system were monitored throughout the season. Use of the line source technique facilitated the imposition of a range of moisture stress levels as indicated by increased water use by sorghum closer to the line source compared with the crop farther away from the line source. Canopy response measured in terms of stomatal conductance, leaf-water potential, and leaf temperature clearly reflected the gradient in moisture stress perpendicular to the line sourc

Neutron diffraction study of stripe order in La(2)NiO(4+d) with d=2/15

We report a detailed neutron scattering study of the ordering of spins and holes in oxygen-doped La(2)NiO(4.133). The single-crystal sample exhibits the same oxygen-interstitial order but better defined charge-stripe order than that studied previously in crystals with d = 0.125. In particular, charge order is observed up to a temperature at least twice that of the magnetic transition, T_m = 110.5 K. On cooling through T_m, the wave vector \epsilon, equal to half the charge-stripe density within an NiO(2) layer, jumps discontinuously from 1/3 to 0.2944. It continues to decrease with further cooling, showing several lock-in transitions on the way down to low temperature. To explain the observed lock-ins, a model is proposed in which each charge stripe is centered on either a row of Ni or a row of O ions. The model is shown to be consistent with the l-dependence of the magnetic peak intensities and with the relative intensities of the higher-order magnetic satellites. Analysis of the latter also provides evidence that the magnetic domain walls (charge stripes) are relatively narrow. In combination with a recent study of magnetic-field-induced effects, we find that the charge stripes are all O-centered at T>T_m, with a shift towards Ni centering at T<T_m. Inferences concerning the competing interactions responsible for the the temperature dependence of \epsilon and the localization of charge within the stripes are discussed.Comment: ReVTeX, 17 2-col pages, 10 eps figs. embedded with psfig, submitted to Phys. Rev.

Regional earth system modelling framework for CORDEX-SA: an integrated model assessment for Indian summer monsoon rainfall

An effort is made to implement a regional earth system model (RESM); ROM, over CORDEX-South Asia (SA). The added value of RESM is assessed for mean precipitation, its variability (intraseasonal to interannual), extremes, and associated processes. In this regard, ROM’s fields are compared with the respective fields of its standalone version (REMO), the models belonging coupled model intercomparison project (CMIP5 and CMIP6), and regional climate models of CORDEX-CORE simulations. RESM shows substantial improvement for most of the Indian monsoon’s aspects; however, the magnitude of the value addition varies spatiotemporally and also with different aspects.. The improved representation of intraseasonal variability (active-break spell’s duration and intensity) and Interannual variability attributed to improved mean seasonal precipitation. Additionally, correct representation of sea surface temperature, Indian Ocean Dipole, and its underlying dynamics also contribute to improving the mean precipitation. The notable improvement is seen especially over the south-eastern regions of the Bay of Bengal (BoB) and South-Central India, where increasing (decreasing) low-pressure systems over Central India (BoB) are noticed as a consequence of air-sea coupling, leading to enhanced (reduced) precipitation over Central India (BoB), reducing dry (wet) bias found in REMO and the other models. Despite substantial improvements, RESM has a systematic wet bias in the mean precipitation associated with a warm bias over the western coast of the Arabian Sea. An overestimation of very high extreme precipitation due to the enhanced contribution of low-pressure systems indicates the model’s limitations, suggesting the need for further tuning of the RESM