Proximate composition and functional analysis of some polyherbal formulations as potential botanical candidates for antidiabetic screening: A Preliminary study

Polyherbal formulations improve therapeutic action while lowering single herb concentration, thereby reducing possible side reactions. Proximate composition and functional properties of tomato, garlic, and carrot formulations were studied. Fresh samples of the botanicals were collected, identified and authenticated. Equal amount of each sample (500 g) was weighed, shed-dried and crushed into fine powdered particles. The proximate composition and functional properties of each formulation were determined according to a standard assay guideline. The result on proximate composition analysis revealed a significant (p ˂ 0.05) higher moisture content of tomato and carrot formulations when compared to other formulations. The content of ash and crude protein were significantly (p ˂ 0.05) higher in all garlic containing formulations. The garlic formulation was observed to have lower fat content and greater carbohydrate content than all other formulations (p˂ 0.05). However, when compared to single formulations, all mixed formulations had significantly higher crude fiber content. Furthermore, there was a significant (p ˂ 0.05) variation in glucose adsorption capacity, oil adsorption capacity and water adsorption capacity among all the formulations. The outcome of this study have led us to conclude that employing safe combinations of these herbal formulations for the production of nutraceuticals is recommended

Ethanolic leaf extract of Langenaria breviflora (bitter gourd) inhibits gastric onslaught in indomethacininduced ulcerated rats

Objective: Gastrointestinal toxicity remains a barrier to applications of non-steroidal anti-inflammatory drugs in medical practice. Plant extract with excellent therapeutic potential may proffer solution to this menace. Thisstudy investigated the gastroprotective effect of Lagenaria breviflora leaves extract against indomethacinmediated gastric ulcer in rats.Methodology and result: Ulceration in the rat was induced by a single oral dose of indomethacin (60 mg/kg body weight). Ulcerated rats were orally administered with Lagenaria breviflora extract at 200 mg/kg body weight once daily for 21 days prior to and after ulcer induction. Gastric secretions and antioxidant parameters were then evaluated. The study indicates that indomethacin caused a significant increase in ulcer index, gastric acidity, malondialadehyde level and pepsin activity. Administration of Lagenaria breviflora in rats reversed these metabolic alterations. The extract also attenuated the reduced activity of catalase, pH and mucin content in the ulcerated rats.Conclusions and application of findings: These findings are indicative of gastroprotective and antioxidative attributes of the extract, which is revealed in the percentage protection offered against ulceration. Thesupportive evidences in this study suggest that the effect of leaves extract of Lagenaria breviflora proved to be capable of modulating indomethacin-mediated gastric ulceration and could be harnessed as preventive therapyin the treatment of gastric ulcer related disorder.Key words: Gastroprotective; H2 receptor; Medicinal; NSAIDS; Proton pump inhibitor; Ulceration

Large scale distribution of total mass versus luminous matter from Baryon Acoustic Oscillations: First search in the SDSS-III BOSS Data Release 10

Baryon Acoustic Oscillations (BAOs) in the early Universe are predicted to leave an as yet undetected signature on the relative clustering of total mass versus luminous matter. A detection of this effect would provide an important confirmation of the standard cosmological paradigm and constrain alternatives to dark matter as well as non-standard fluctuations such as Compensated Isocurvature Perturbations (CIPs). We conduct the first observational search for this effect, by comparing the number-weighted and luminosity-weighted correlation functions, using the SDSS-III BOSS Data Release 10 CMASS sample. When including CIPs in our model, we formally obtain evidence at $3.2\sigma$ of the relative clustering signature and a limit that matches the existing upper limits on the amplitude of CIPs. However, various tests suggest that these results are not yet robust, perhaps due to systematic biases in the data. The method developed in this Letter, used with more accurate future data such as that from DESI, is likely to confirm or disprove our preliminary evidence.Comment: 6 pages, 2 figures, accepted for publication in PR

PREVALENCE AND CHARACTERIZATION OF LISTERIA MONOCYTOGENES ISOLATED FROM DIFFERENT FOOD PRODUCTS

During the period 2006-2009, 453 samples of various food products were collected and analyzed for Listeria monocytogenes. In order to increase the knowledge of the ecology and epidemiology of this organism, isolates were characterized by serotyping, and PCR for the presence of the main virulence-associated genes and genetic relatedness

Scale Dependence of Halo Bispectrum from Non-Gaussian Initial Conditions in Cosmological N-body Simulations

We study the halo bispectrum from non-Gaussian initial conditions. Based on a set of large $N$-body simulations starting from initial density fields with local type non-Gaussianity, we find that the halo bispectrum exhibits a strong dependence on the shape and scale of Fourier space triangles near squeezed configurations at large scales. The amplitude of the halo bispectrum roughly scales as $f_nl^2$. The resultant scaling on the triangular shape is consistent with that predicted by Jeong & Komatsu based on perturbation theory. We systematically investigate this dependence with varying redshifts and halo mass thresholds. It is shown that the $f_nl$ dependence of the halo bispectrum is stronger for more massive haloes at higher redshifts. This feature can be a useful discriminator of inflation scenarios in future deep and wide galaxy redshift surveys.Comment: 27 pages, 10 figures; revised argument in section 6, added appendix C, JCAP accepted versio

Statistical Determination of Bulk Flow Motions

We present here a new parameterization for the bulk motions of galaxies and clusters (in the linear regime) that can be measured statistically from the shape and amplitude of the two-dimensional two-point correlation function. We further propose the one-dimensional velocity dispersion (v_p) of the bulk flow as a complementary measure of redshift-space distortions, which is model-independent and not dependent on the normalisation method. As a demonstration, we have applied our new methodology to the C4 cluster catalogue constructed from Data Release Three (DR3) of the Sloan Digital Sky Survey. We find v_p=270^{+433}km/s (also consistent with v_p=0) for this cluster sample (at z=0.1), which is in agreement with that predicted for a WMAP5-normalised LCDM model (i.e., v_p(LCDM=203km/s). This measurement does not lend support to recent claims of excessive bulk motions (\simeq1000 km/s) which appear in conflict with LCDM, although our large statistical error cannot rule them out. From the measured coherent evolution of v_p, we develop a technique to re-construct the perturbed potential, as well as estimating the unbiased matter density fluctuations and scale--independent bias.Comment: 8 pages, 5 figure

A new Low Gain Avalanche Diode concept: the double-LGAD

This paper describes the new concept of the double-LGAD. The goal is to increase the charge at the input of the electronics, keeping a time resolution equal or better than a standard (single) LGAD; this has been realized by adding the charges of two coupled LGADs while still using a single front-end electronics. The study here reported has been done starting from single LGAD with a thickness of 25 \textmu{m}, 35 \textmu{m} and 50 \textmu{m}.Comment: arXiv admin note: text overlap with arXiv:2208.0571

First results on monolithic CMOS detector with internal gain

: In this paper we report on a set of characterisations carried out on the first monolithic LGAD prototype integrated in a customised 110 nm CMOS process having a depleted active volume thickness of 48 μm. This prototype is formed by a pixel array where each pixel has a total size of 100 μm × 250 μm and includes a high-speed front-end amplifier. After describing the sensor and the electronics architecture, both laboratory and in-beam measurements are reported and described. Optical characterisations performed with an IR pulsed laser setup have shown a sensor internal gain of about 2.5. With the same experimental setup, the electronic jitter was found to be between 50 ps and 150 ps, depending on the signal amplitude. Moreover, the analysis of a test beam performed at the Proton Synchrotron (PS) T10 facility of CERN with 10 GeV/c protons and pions indicated that the overall detector time resolution is in the range of 234 ps to 244 ps. Further TCAD investigations, based on the doping profile extracted from C(V) measurements, confirmed the multiplication gain measured on the test devices. Finally, TCAD simulations were used to tune the future doping concentration of the gain layer implant, targeting sensors with a higher avalanche gain. This adjustment is expected to enhance the timing performance of the sensors of the future productions, in order to cope with the high event rate expected in most of the near future high-energy and high-luminosity physics experiments, where the time resolution will be essential to disentangle overlapping events and it will also be crucial for Particle IDentification (PID

The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey : baryon acoustic oscillations in the Data Releases 10 and 11 Galaxy samples

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations (BAO) in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 (DR11) sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released DR9 and DR10 samples. Assuming a concordance Λ cold dark matter (ΛCDM) cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = (1264 ± 25 Mpc)(rd/rd,fid) at z = 0.32 and DV = (2056 ± 20 Mpc)(rd/rd,fid) at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = (1421 ± 20 Mpc)(rd/rd,fid) and H = (96.8 ± 3.4 km s−1 Mpc−1)(rd,fid/rd). Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant.Publisher PDFPeer reviewe

Friends-of-Friends Groups and Clusters in the 2SLAQ Catalogue

We present a catalogue of galaxy groups and clusters selected using a friends-of-friends algorithm with a dynamic linking length from the 2dF-SDSS and QSO (2SLAQ) luminous red galaxy survey. The linking parameters for the code are chosen through an analysis of simulated 2SLAQ haloes. The resulting catalogue includes 313 clusters containing 1,152 galaxies. The galaxy groups and clusters have an average velocity dispersion of sigma_v = 467.97 km/s and an average size of R_clt = 0.78 Mpc/h. Galaxies from regions of one square degree and centred on the galaxy clusters were downloaded from the Sloan Digital Sky Survey Data Release 6 (SDSS DR6). Investigating the photometric redshifts and cluster red-sequence of these galaxies shows that the galaxy clusters detected with the FoF algorithm are reliable out to z~0.6. We estimate masses for the clusters using their velocity dispersions. These mass estimates are shown to be consistent with 2SLAQ mock halo masses. Further analysis of the simulation haloes shows that clipping out low richness groups with large radii improves the purity of catalogue from 52% to 88%, while retaining a completeness of 94%. Finally, we test the two-point correlation function of our cluster catalogue. We find a best-fitting power law model with parameters r0 = 24\pm4 Mpc/h and gamma = -2.1\pm 0.2, which are in agreement with other low redshift cluster samples and consistent with a {\Lambda}CDM universe.Comment: 17 pages, 14 figure