Digital Education, Geography and Multidisciplinarity: Themes, Methods and Critical Issues

In the last few years education has been strongly marked by the digital paradigm: captivating resources, new teaching tools, methodologies and unprecedented interactions between teachers and students have become part of the scientific debate on new teaching/learning processes. This has had positive effects on teachers leading them to new stimuli and new ways of boosting creativity in their didactic approach. The pandemic period has acted as a catalyst of this digital progress in the education field and has also provided the foundation for a scientific reflection on this matter as can be seen in many international congresses and research programs. The visual nature of Geography, both in terms of study and research of the landscape and with reference to cartographic production and analysis, seems to be more involved in this change. Moreover, the propensity of Geography to multidisciplinarity – subject which can be seen as a synthesis of various disciplines including social sciences – implies an in-depth reflection on several levels. This is why when analyzing digital education in reference to Geography it is necessary to take into account themes, methods and critical issues that are at the heart of an ongoing teaching/learning process. In this Special Issue we intend to explore links between the teaching/learning of Geography (at any school/university level) and the digital world, even in a multidisciplinary perspective, including both the critical issues and the advantages in terms of sustainability and greater awareness of geographical phenomena also in relation with cultural dynamics (e.g. migrations, urban transformations, development, geopolitics, tourism)

Sustainability and risk perception: multidisciplinary approaches

Editorial to the special issue "Sustainability and risk perception: multidisciplinary approaches

Special Issue: Sustainability and risk perception: multidisciplinary approaches

Leonardo Mercatanti and Gaetano Sabato were guest editors of a special issue of the peer-​reviewed journal AIMS Geoscience "Sustainability and risk perception: multidisciplinary approaches". Within the scientific discourse of Geography and Social Sciences, the concepts of “sustainability” and “risk perception” often represent two complementary issues of the same dynamic. One mutually implies the other in different and complex ways and yet they are often dealt as two separate matters. Approaching the latter together as part of the same dialectical process, however allows us to gain a better insight on their interaction. For example, if we consider that risk perception implies forms of power and social relationships then the perception of volcanic risk could suggest sustainable security policies. Or, again, how risk perception could be connected to sustainable habits i.e. in the case of waste management, the real danger of unsustainability can positively affect more responsible behaviours and even encourage recycling. And once more, how some consumers’ behaviours are caused by specific risk perceptions i.e. the fear of pauperizing private and public resources leads to group purchases trends. This Special Issue of AIMS Geosciences aims to focus on some issues related to the topic of Sustainability and Risk perception. We think that a multi- and inter-disciplinary approach is really useful to try answering questions such as: how do these two poles interact? How do they influence (and/or affect) each other reciprocally? What kind of correlation exists between them? For this purpose, we encourage scholars of different disciplines and/or various fields of study to contribute with theoretical reflections, experiences and case studies

Long-term efficacy of OROS® hydromorphone combined with pregabalin for chronic non-cancer neuropathic pain.

BACKGROUND AND OBJECTIVES: Treatment for chronic non-cancer neuropathic pain can be complicated by side effects and drug interactions. Combining opioid analgesics and calcium channel modulators may overcome these and improve efficacy. The objective of the present study was to evaluate the efficacy and safety of OROS® hydromorphone combined with pregabalin in patients with chronic non-cancer neuropathic pain. METHODS: This retrospective observational study was conducted on clinical records from patients aged ≥18 years with chronic non-cancer neuropathic [>4 on the Douleur Neuropathique en 4 questions (DN4) scale] pain of ≥6 months duration, with severe intensity [>4 on the Numerical Rating Scale (NRS); range 0-10], who attended all visits and had ≥12 months of follow-up at the Tor Vergata University Polyclinic Hospital, from November 2008 to February 2011. Patients received an oral combination of OROS® hydromorphone and pregabalin. Pain was evaluated at each visit (months 1, 3, 6, 9, and 12) using the NRS and DN4 scale; Patients' Global Impression of Change (PGIC) was administered at months 1, 6, and 12. Dosage and side effects were recorded at each visit. RESULTS: Of 1,292 patients (32 % men, mean ± SD age 67.6 ± 11.9 years), 1,126 attended all visits. Seventeen percent (n = 224) had purely neuropathic pain. Initial mean dosage was 6.06 ± 2.00 mg/day for OROS® hydromorphone, 113.02 ± 21.94 mg/day for pregabalin. Dosages increased up to month 6, and returned to near initial dosages at month 12 (range 4-120 mg/day for OROS® hydromorphone; 75-600 mg/day for pregabalin). NRS pain scores (mean ± standard deviation) were 7.25 ± 1.34 at baseline and 1.85 ± 1.36 at 12 months (p < 0.0001); DN4 scores were 6.19 ± 1.65 at baseline, reduced to 1.84 ± 1.25 at 12 months (p < 0.0001), reductions of 74.4 and 70.2 %, respectively. More than 90 % of patients had a ≥50 % score reduction on both scales after 12 months. The PGIC scale showed that >75 % of patients felt improvement at 1 month, increasing to 91 % and 93 % at 6 and 12 months. The incidence of side effects was similar between elderly (aged >65 years) and younger subjects; there were no cases of addiction. CONCLUSIONS: The OROS® hydromorphone and pregabalin combination was efficacious for chronic non-cancer neuropathic pain and well tolerated, providing significant pain reduction without the risk of addiction and with a good tolerability profile, regardless of age

Interface stability between bare, Mn-Co spinel coated AISI 441 stainless steel and a diopside-based glass-ceramic sealant

This document is the Accepted Manuscript version of the following article: A. G. Sabato, A. Crysanthou, M. Salvo, G. Tempura, and F. Smeacetto, ‘Interface stability between bare, Mn-Co spinel coated AISA 441 stainless steel and a diopside-based glass-ceramic sealant’, International Journal of Hydrogen Energy, Vol. 43 (13): 1824-1834, January 2018, made available under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License CC BY NC-ND 4.0 ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. Under embargo until 16 December 2018. The final, definitive version of this paper is available online at doi: https://doi.org/10.1016/j.ijhydene.2017.11.150.This study is focused on a diopside-based glass-ceramic sealant for solid oxide fuel cells and its compatibility with AISI 441 stainless steel interconnect. The morphological and chemical stability with both bare and Mn–Co spinel coated AISI 441 steel, after 3500 h exposure at 800 °C in air, is reviewed and discussed. Post-mortem samples are morphologically and chemically analysed by SEM-EDS. Reaction products at the glass-ceramic/bare AISI 441 interface, resulting from the reaction of Mg from the sealant and Cr and Mn from the steel, are detected, without affecting negatively the integrity of the joints. In the case of Mn–Co spinel coated AISI 441, interactions between the glass-ceramic and the outer part of the Mn–Co spinel coating, along with crystallization of oxides rich in Si and Mg, are detected, but still no corrosion phenomena are present. The glass-ceramic is found to be compatible with both bare and coated AISI 441.Peer reviewe

Sonic hedgehog medulloblastoma cancer stem cells mirnome and transcriptome highlight novel functional networks

Molecular classification has improved the knowledge of medulloblastoma (MB), the most common malignant brain tumour in children, however current treatments cause severe side effects in patients. Cancer stem cells (CSCs) have been described in MB and represent a sub population characterised by self-renewal and the ability to generate tumour cells, thus representing the reservoir of the tumour. To investigate molecular pathways that characterise this sub population, we isolated CSCs from Sonic Hedgehog Medulloblastoma (SHH MB) arisen in Patched 1 (Ptch1) heterozygous mice, and performed miRNA-and mRNA-sequencing. Comparison of the miRNA-sequencing of SHH MB CSCs with that obtained from cerebellar Neural Stem Cells (NSCs), allowed us to obtain a SHH MB CSC miRNA differential signature. Pathway enrichment analysis in SHH MB CSCs mirnome and transcriptome was performed and revealed a series of enriched pathways. We focused on the putative targets of the SHH MB CSC miRNAs that were involved in the enriched pathways of interest, namely pathways in cancer, PI3k-Akt pathway and protein processing in endoplasmic reticulum pathway. In silico analysis was performed in SHH MB patients and identified several genes, whose expression was associated with worse overall survival of SHH MB patients. This study provides novel candidates whose functional role should be further investigated in SHH MB

Controlled-release oxycodone and pregabalin in the treatment of neuropathic pain: results of a multicenter Italian study

Abstract AIMS: The aim of our study was to compare the efficacy, safety, and quality of life of combination therapy with controlled-release (CR) oxycodone plus pregabalin versus monotherapy with either CR oxycodone or pregabalin in patients with neuropathic pain. MATERIALS AND METHODS: Patients with moderate to severe neuropathic pain, despite the use of various pharmacologic treatments prior to study entry, were enrolled (n = 409) and treated with CR oxycodone plus pregabalin (n = 169), CR oxycodone (n = 106), and pregabalin (n = 134). Pain intensity was rated on an 11-point numerical rating scale (NRS). RESULTS: The combination of CR oxycodone plus pregabalin and CR oxycodone monotherapy were both more effective for alleviating neuropathic pain than pregabalin monotherapy (reduction in NRS value: 80, 76, and 46%, respectively; p </= 0.003). Significantly greater improvements from baseline in quality of life were reported with combination therapy than with monotherapy (p = 0.0009). At the end of treatment, the majority (91.2%) of patients receiving CR oxycodone plus pregabalin found that the treatment had been 'effective' or 'very effective'. Combination therapy also allowed a dose reduction of both agents (22% for CR oxycodone and 51% for pregabalin) compared with the dosages of the respective monotherapies. Combination therapy had a superior safety profile compared with pregabalin monotherapy. CONCLUSIONS: The combination of CR oxycodone plus pregabalin may represent a valuable addition to the existing pharmacotherapy for neuropathic pain and warrants further investigation

Bodies, emotions and tourism: a study of Costa Cruises commercials

Nowadays, tourism industry proposes different opportunities to live a vacation where the body is the main interest and the central focus of experience. Each form of tourism shows a particular universe of representation of the body and a corresponding emotional language. In this context, where bodies and spaces are associated and reciprocally constructed as symbolic languages for the benefit of the tourist’s extraordinary experience, cruise tourism is an interesting case in point to analyze above all because on cruises, people use the space of the ship in different ways and, at the same time, following general corporeal and spatial schemes. These uses and schemes reflect a particular conception of the body, built through an interaction of different systems of representation, which transforms the ship into a real and true space for social aggregation or separation. The analysis we propose has a double methodological perspective: it is based, on the one hand, on a fieldwork accomplished on a ‘Costa Crociere’ cruise in the Mediterranean Sea; on the other hand, it is built on the meaning conveyed by different spot advertisements of the Costa website where the company suggest to the future passengers an exclusive experience. We will analyze these ads using a joint anthropology and linguistics approach. In particular, in order to analyze the chosen advertisements, a cognitive linguistics approach will be applied to show how the behavior of the passengers on the cruise is influenced by the linguistic choices of the spot advertisements that prefigure emotions