4 research outputs found
Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations
The experimental determination of the relative biological effectiveness of thermal neutron
factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained
while using mixed beams that consist of both neutrons and photons of various energies. A common
weighting factor has been used for both thermal and fast neutron doses, although such an approach has
been questioned. At the nuclear reactor of the Institut Laue-Langevin a pure low-energy neutron beam
has been used to determine thermal neutron relative biological effectiveness factors. Different cancer
cell lines, which correspond to glioblastoma, melanoma, and head and neck squamous cell carcinoma,
and non-tumor cell lines (lung fibroblast and embryonic kidney), have been irradiated while using
an experimental arrangement designed to minimize neutron-induced secondary gamma radiation.
Additionally, the cells were irradiated with photons at a medical linear accelerator, providing reference
data for comparison with that from neutron irradiation. The survival and proliferation were studied
after irradiation, yielding the Relative Biological Effectiveness that corresponds to the damage of
thermal neutrons for the different tissue types.Asociacion Espanola Contra el Cancer (AECC)
PS16163811PORRSpanish MINECO
FIS2015-69941-C2-1-PJunta de Andalucia
P11-FQM-8229Campus of International Excellence BioTic
P-BS-64University of Granada Chair Neutrons for Medicine: the Spanish Fundacion ACSAsociacion Capitan AntonioFundacion ACSLa Kuadrilla de IznallozSonriendo Se Puede Gana
Radiobiology data of melanoma cells after low-energy neutron irradiation and boron compound administration
The cold neutron beam at the PF1b line at the Institut Laue-Langevin (ILL), without fast neutrons and a low contribution of gamma rays, is a very suitable facility to measure cell damage following low-energy neutron irradiation. The biological damage associated with the thermal and the boron doses can be obtained in order to evaluate the relative biological effectiveness (RBE) for Boron Neutron Capture Therapy. Three different experiments were carried out on the A375 melanoma cell line: the first one in a hospital LINAC, to obtain the reference radiation data, and the other two at the ILL, in which the damage to cells with and without boron compounds added was measured