Emotional Stability of Nurses and Its Relation to Their Job Crafting

Context: Emotional stability is the process in which the personality is continuously striving for a greater sense of emotional health. Job crafting and can be seen as a specific form of proactive behavior in which the nurse initiates changes (redesign) in the level of job demands and job resources to make their job more meaningful. Nurses with high emotional stability are more tending to adapt to changes in their job and enhance their job crafting. Aim: This study aimed to assess the emotional stability of nurses and their relation to their job crafting.Methods: The study was conducted at the Psychiatric Mental Health Hospital in Benha city, Qalubia governorate, Egypt. A convenient sample of 100 nurses working in the setting mentioned above. A descriptive correlational design was utilized to achieve the aim of the study. Two tools were used for data collection, namely; the Emotional Stability Assessment Questionnaire and the Job Crafting Assessment Scale.Results: The results reveal that near to two-thirds (63%) of the studied nurses had a moderate level of emotional stability, and near to half (48%) of the studied nurses reported a low level of job crafting.Conclusion: The study concluded that there was a positive, highly statistically significant correlation between the emotional stability of the studied nurses and their job crafting. Recommendation: Conduction of further studies in order to assess the relationship between emotional stability and job crafting with replication of this study on a larger probability sample from different geographical locations at the Arab Republic of Egypt. In addition to the establishment of a training program about emotional stability for nurses as needed, particularly those working under a stressful situation like the psychiatric mental health nurses, and identify the needed corrective actions. Hospital administrators and nursing decision-makers should encourage the conduction of workshops regarding job crafting for nurses

Etude in vivo du rôle de la région régulatrice en 3' du locus des chaînes lourdes d'immunoglobulines dans les réactions inflammatoires et la lymphomagenèse B

B-cell maturation is under the control of the cis-regulatory elements of Ig genes. The four transcripional enhancers (hs3a, hs1,2, hs3b and hs4) of the mouse IgH 3’ regulatory region (3’RR) are the key elements for somatic hypermutation (SHM) and class-switch recombination (CSR). The 3'RR also stimulates Ig transcription during the mature B-cell stage. When associated with an oncogene, the 3’RR is a potent deregulator leading to B-cell lymphomas. Currently nothing is known about its role in the development of immune and inflammatory reactions. During my thesis, we have studied the impact of the 3’RR deletion on the development of inflammatory reactions in response to pristane in BALB/c mice. These studies have allowed us to show that the lack of the 3'RR does not disturb the development of an efficient inflammatory reaction in response to pristane (kinetics of appearance of ascites, volume, cellularity, recruitment of inflammatory cells and their capacity to produce inflammatory and anti-inflammatory cytokines). This suggests the presence of B-cells physiologically capable to induce/spread/maintain a robust and efficient inflammatory immune response. After studying the role of the deletion of the 3'RR in an inflammatory context we have investigated the role of the 3’RR in a lymphomagenesis. For this we brought the 3’RR deficiency in a genetic background able to develop mature B-cell lymphomas (Igλ-Myc mice). While wt mice develop mature and immature B-cell lymphomas, 3’RR-deficient mice exhibit a strong preference for immature lymphomas. Furthermore 3’RR-deficiency leads to a lowered frequency of CD43+ activated B-cell lymphomas and to an increased frequency of CD5+ B-cell lymphomas. CSR and SHM are abrogated in 3’RR-deficient mice lowering the probability of oncogenic mutations during these stages. Pharmacological targeting of 3'RR to block its transcriptional pro-oncogenic effect on translocated oncogene into IgH locus might be a promising approach for the treatment of some mature human B-cell lymphomas.La maturation lymphocytaire B est sous le contrôle des éléments cis-régulateurs des gènes d’Ig. Les quatre activateurs transcriptionnels (hs3a, hs1,2, hs3b et hs4) de la région régulatrice en 3’ du locus IgH (3’RR) murin sont les éléments clés pour les hypermutations somatiques (SHM) et les recombinaisons isotypiques (CSR). La 3’RR stimule aussi la transcription d’Ig au stade mature du développement B. La 3’RR, en association avec un oncogène, est un dérégulateur puissant conduisant au développement de lymphomes B. Actuellement rien n’est connu sur le rôle de la 3’RR lors de réactions immunes et/ou inflammatoires normales. Durant ma thèse, nous avons étudié l’impact de la délétion de la 3’RR sur le développement d’une réaction inflammatoire en réponse au pristane chez les souris BALB/c. Ces études nous ont permis de montrer que l’absence de la 3’RR ne perturbe pas l’apparition d’une réaction inflammatoire (cinétique de l’ascite, volume, cellularité, recrutement en cellules inflammatoires et leur capacité à produire des cytokines inflammatoires et anti-inflammatoires). Ceci suggère la présence de lymphocytes B physiologiquement aptes à induire/propager/maintenir une réaction inflammatoire et immune robuste et efficiente en absence d’une 3’RR fonctionnelle. Après avoir étudié le rôle de la délétion de la 3’RR dans un contexte inflammatoire, nous avons analysé son rôle dans un contexte de lymphomagenèse. Pour cela nous avons mis l’absence de la 3’RR dans un fond génétique murin apte à développer des lymphomes B matures (souris Igλ-Myc). On observe un changement important dans le phénotype des lymphomes B en absence de la 3’RR avec un plus grand nombre de lymphomes B immatures, une baisse du nombre de lymphomes B matures CD43+ et une augmentation de lymphomes B CD5+. Le rôle de la 3’RR dans la survenue de mutations aux stades B matures durant la SHM et la CSR est suggéré pour expliquer ces résultats. En conclusion, le ciblage pharmacologique de la 3’RR pour bloquer son effet pro-oncogènique transcriptionnel sur un oncogène transloqué au locus IgH pourrait se révéler une approche prometteuse pour le traitement de certains lymphomes B matures humains

Family Problems Experienced by Students of the University of Jordan

The study has aimed at identifying the family problems among the students of the University of Jordan. The descriptive survey method has been used, and the questionnaire has been used as a tool for the study. (604) students have been selected in a stratified random manner from the University of Jordan as a sample for the study. The study results have showed that the most important and prominent family problems experienced by the University of Jordan students are: Problems in communication between family members, problems with emotional expression, lack of respect among family members, and lack of trust in the relationship with the parents. The results also showed that there are no statistically significant differences in family problems experienced by the University of Jordan students from the viewpoint of the students themselves due to the variables of gender, college, and the interaction between them both

Workaholism, sleep disorders, and potential e-learning impacts among Menoufia university staff during COVID–19 pandemic

Background: Workaholism is described as a constant, internal drive to work and behavioral addiction to work. Studies have shown the negative associations between workaholism, job performance, and health results as disrupted sleep. The purpose of this research was to compare the prevalence of workaholics among the academic staff of practical and theoretical Faculties in Egyptian universities using the Dutch Workaholism Scale (DUWAS) and to determine associated sleep problems. Also, it studied the added impact of E-learning on the prevalence of workaholism frequency during the COVID-19 pandemic. Design and Methods: A cross-sectional study was conducted among 336 participants. Work addiction was assessed using DUWAS (17 items) as well as questionnaires on personal, occupational characteristics, and sleep problems. DUWAS scale was repeated after six months during COVID 19 pandemic to investigate the impact of E-learning on the workaholic behavior of the studied groups. Results: Our study revealed that the prevalence of workaholism was 33 percent. 32.8% and 33.7% were listed for the faculties of Medicine and Arts, respectively. After the COVID-19 pandemic, workaholic frequency was significantly increased to be 46.4%. Adjusted logistic regression analysis showed that workaholism had negatively impacted sleep in terms of difficulty initiating sleep, difficulty maintaining sleep, and insufficient sleep. Conclusion: The prevalence of workaholism appears to be high among university staff members especially after COVID-19 crisis. Sleep problems were linked to workaholics more than other workers. We recommend encouraging employees to work to their contracted hours, as excess work over extended periods may have adverse effects not only on organizational productivity but also on their health

Psychological Assessment in Children with Chronic Kidney Disease on Regular Hemodialysis

Introduction: Interestingly, health care professionals have the tendency to focus on the biological dimension of the disease or other technical issues related to hemodialysis machine and usually underestimate symptoms from mental sphere. Encouraging patients to express their feelings and addressing their psychological needs may be an essential measure to confront with this debilitating disease. Aim of Study: The objective of our study were to assess the presence, possible factors related and consequences of psychological disorders in children with CKD on regular hemodialysis. Methods: This study was cross sectional study which carried out in nephrology unit of the pediatric department during the period from February 2021 to January   2022.It were comprised (141) children with CKD on regular hemodialysis of both sexes after obtaining informed consent from children\u27s parents. All patients were subjected to history (age, sex, residence, birth order, level of education, socioeconomic status), examination and specific investigations. Results: This study showed that, a male predominance. Regarding anxiety grade, mild were 18 (12.8%), moderate were 54 (38.3%) and severe were 69 (48.9%). Regarding depression grade, mild were 50 (35.5%), moderate were 54 (38.3%), and severe were 19 (13.5%) while no depression was found among 18 (12.8%). There were statistically significant positive correlations between anxiety score and duration of dialysis. There were statistically significant positive correlations between anxiety score and depression score. Conclusion: Frequency of anxiety and depression is high in CKD Patients. There were statistically significant positive correlations between anxiety score and depression score

in vivo Study of the role of the regulatory region in 3’ of immunoglobuline heavy chaines locus in the inflammatory reaction and lymphomagenesis B in mice

La maturation lymphocytaire B est sous le contrôle des éléments cis-régulateurs des gènes d’Ig. Les quatre activateurs transcriptionnels (hs3a, hs1,2, hs3b et hs4) de la région régulatrice en 3’ du locus IgH (3’RR) murin sont les éléments clés pour les hypermutations somatiques (SHM) et les recombinaisons isotypiques (CSR). La 3’RR stimule aussi la transcription d’Ig au stade mature du développement B. La 3’RR, en association avec un oncogène, est un dérégulateur puissant conduisant au développement de lymphomes B. Actuellement rien n’est connu sur le rôle de la 3’RR lors de réactions immunes et/ou inflammatoires normales. Durant ma thèse, nous avons étudié l’impact de la délétion de la 3’RR sur le développement d’une réaction inflammatoire en réponse au pristane chez les souris BALB/c. Ces études nous ont permis de montrer que l’absence de la 3’RR ne perturbe pas l’apparition d’une réaction inflammatoire (cinétique de l’ascite, volume, cellularité, recrutement en cellules inflammatoires et leur capacité à produire des cytokines inflammatoires et anti-inflammatoires). Ceci suggère la présence de lymphocytes B physiologiquement aptes à induire/propager/maintenir une réaction inflammatoire et immune robuste et efficiente en absence d’une 3’RR fonctionnelle. Après avoir étudié le rôle de la délétion de la 3’RR dans un contexte inflammatoire, nous avons analysé son rôle dans un contexte de lymphomagenèse. Pour cela nous avons mis l’absence de la 3’RR dans un fond génétique murin apte à développer des lymphomes B matures (souris Igλ-Myc). On observe un changement important dans le phénotype des lymphomes B en absence de la 3’RR avec un plus grand nombre de lymphomes B immatures, une baisse du nombre de lymphomes B matures CD43+ et une augmentation de lymphomes B CD5+. Le rôle de la 3’RR dans la survenue de mutations aux stades B matures durant la SHM et la CSR est suggéré pour expliquer ces résultats. En conclusion, le ciblage pharmacologique de la 3’RR pour bloquer son effet pro-oncogènique transcriptionnel sur un oncogène transloqué au locus IgH pourrait se révéler une approche prometteuse pour le traitement de certains lymphomes B matures humains.B-cell maturation is under the control of the cis-regulatory elements of Ig genes. The four transcripional enhancers (hs3a, hs1,2, hs3b and hs4) of the mouse IgH 3’ regulatory region (3’RR) are the key elements for somatic hypermutation (SHM) and class-switch recombination (CSR). The 3'RR also stimulates Ig transcription during the mature B-cell stage. When associated with an oncogene, the 3’RR is a potent deregulator leading to B-cell lymphomas. Currently nothing is known about its role in the development of immune and inflammatory reactions. During my thesis, we have studied the impact of the 3’RR deletion on the development of inflammatory reactions in response to pristane in BALB/c mice. These studies have allowed us to show that the lack of the 3'RR does not disturb the development of an efficient inflammatory reaction in response to pristane (kinetics of appearance of ascites, volume, cellularity, recruitment of inflammatory cells and their capacity to produce inflammatory and anti-inflammatory cytokines). This suggests the presence of B-cells physiologically capable to induce/spread/maintain a robust and efficient inflammatory immune response. After studying the role of the deletion of the 3'RR in an inflammatory context we have investigated the role of the 3’RR in a lymphomagenesis. For this we brought the 3’RR deficiency in a genetic background able to develop mature B-cell lymphomas (Igλ-Myc mice). While wt mice develop mature and immature B-cell lymphomas, 3’RR-deficient mice exhibit a strong preference for immature lymphomas. Furthermore 3’RR-deficiency leads to a lowered frequency of CD43+ activated B-cell lymphomas and to an increased frequency of CD5+ B-cell lymphomas. CSR and SHM are abrogated in 3’RR-deficient mice lowering the probability of oncogenic mutations during these stages. Pharmacological targeting of 3'RR to block its transcriptional pro-oncogenic effect on translocated oncogene into IgH locus might be a promising approach for the treatment of some mature human B-cell lymphomas

Pré-évaluation du LAVIA

L'objet de cette pré-évaluation est d'établir un premier diagnostic de « l'utilisabilité » et de « l'acceptabilité » par les conducteurs de l'assistance proposée par le système LAVIA et de fournir des recommandations méthodologiques pour la collecte et l'analyse des données de l'expérimentation sur flotte. Cette pré-évaluation consiste en une analyse approfondie de l'utilisation par les conducteurs du LAVIA « actif non débrayable ». La méthodologie mise en oeuvre et les premiers résultats de cette pré-évaluation sont brièvement présentés ici

Présentation des quatre dimensions de l'évaluation du LAVIA : utilisabilité, utilité, acceptabilité, sécurité avec la justification des choix des dispositifs d'évaluation associés

L'évaluation du LAVIA porte sur quatre dimensions qui sont classiques dans l'évaluation d'un produit : l'utilisabilité, l'utilité, l'acceptabilité et la sécurité. Nous donnons les définitions de ces quatre dimensions et présentons les dispositifs d'enquêtes, de mesures et d'observations qui ont été mis en oeuvre pour les évaluer. Les résultats des évaluations correspondant à ces quatre dimensions sont développés dans les autres fiche

A new 3'RR regulatory role during lymphomagenesis.

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3'RR targeting in lymphomagenesis: a promising strategy?

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