Os dilemas da política industrial e de inovação: os problemas da Região Sudeste são os do Brasil

Bibliografia: p. 314-317O Brasil se defronta, a partir do início dos anos 1980, com uma economia mundial que começa a passar por significativas transformações na organização e dinâmica do setor produtivo, associadas a um ritmo muito mais intenso de mudanças tecnológicas. As grandes empresas transnacionais são os principais atores desse processo, alterando a estrutura industrial brasileira, que havia alcançado um alto grau de integração intersetorial e diversificação da produção. Este trabalho pretende discutir, entre outros temas, os dilemas da industrialização da Região Sudeste, tendo em vista a dependência cada vez maior do aporte de investimentos externos. A abordagem conceitual é a de "sistemas de inovação" articulada com o conceito de convenções de desenvolvimento, para explicar os principais dilemas que levaram à construção de duas convenções diferenciadas e até antagônicas. Na primeira - institucionalista restrita -, a inovação tem na abertura internacional um importante papel em seu estímulo, por meio da importação de tecnologias mais produtivas. Na segunda - neodesenvolvimentista -, o Estado tem um papel mais ativo na política de inovação, utilizando uma série de mecanismos.Since the beginning of the 1980s, Brazil has been faced with a global economy that has undergone significant changes in terms of both the organization and dynamics of the production sector, which are associated with a more intense pace of technological change. Larger transnational companies are the main players within such a process, modifying Brazil's industrial structure, which had achieved a high level of inter-sectorial integration and production diversification. Among other themes, this paper intends to discuss the dilemmas of industrialization in the Southeast Region, taking into account the ever-growing dependence on foreign investment. The conceptual approach deals with "innovation systems" in connection with the concept of development conventions in order to explain the main dilemmas that led to the creation of two differentiated, and even opposing, conventions. In the first - the restricted institutionalist convention - innovation, as a tool for opening up an international market, has an important role as a booster due to imports of more productive technologies. In the second - the neodevelopmentalist convention -, the State plays a more active role in the innovation policy, using a series of mechanisms, such as tax incentives, subsidized credit and subventions

Mudanças institucionais e tecnologia: impactos da liberalização sobre o sistema nacional de inovações

Incluye Bibliografí

Institutional change and technology: impacts of deregulation on the national innovation system

Includes bibliograph

Panorama do setor de telecomunicações

Bibliografia: p. 48-49

CDH1/E-cadherin and solid tumors. An updated gene-disease association analysis using bioinformatics tools

Cancer is a group of diseases that causes millions of deaths worldwide. Among cancers, Solid Tumors (ST) stand-out due to their high incidence and mortality rates. Disruption of cell–cell adhesion is highly relevant during tumor progression. Epithelial-cadherin (protein: E-cadherin, gene: CDH1) is a key molecule in cell–cell adhesion and an abnormal expression or/and function(s) contributes to tumor progression and is altered in ST. A systematic study was carried out to gather and summarize current knowledge on CDH1/E-cadherin and ST using bioinformatics resources. The DisGeNET database was exploited to survey CDH1-associated diseases. Reported mutations in specific ST were obtained by interrogating COSMIC and IntOGen tools. CDH1 Single Nucleotide Polymorphisms (SNP) were retrieved from the dbSNP database. DisGeNET analysis identified 609 genes annotated to ST, among which CDH1 was listed. Using CDH1 as query term, 26 disease concepts were found, 21 of which were neoplasms-related terms. Using DisGeNET ALL Databases,172 disease concepts were identified. Of those, 80 ST disease-related terms were subjected to manual curation and 75/80 (93.75%) associations were validated. On selected ST, 489 CDH1 somatic mutations were listed in COSMIC and IntOGen databases. Breast neoplasms had the highest CDH1- mutation rate. CDH1 was positioned among the 20 genes with highest mutation frequency and was confirmed as driver gene in breast cancer. Over 14,000 SNP for CDH1 were found in the dbSNP database. This report used DisGeNET to gather/compile current knowledge on gene-disease association for CDH1/E-cadherin and ST; data curation expanded the number of terms that relate them. An updated list of CDH1 somatic mutations was obtained with COSMIC and IntOGen databases and of SNP from dbSNP. This information can be used to further understand the role of CDH1/E-cadherin in health and disease.Fil: Abascal, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Besso, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rosso, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mencucci, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Aparicio, Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Szapiro, Gala. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Furlong, Laura Ines. Universitat Pompeu Fabra; EspañaFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin