Initiating End-of-Life Care at the Emergency Department: An Observational Study

10.1177/1049909119836931American Journal of Hospice and Palliative Medicine1049909119836931

Overexpression of Pak1 and Pak4 contributes to endometrial carcinogenesis

Late-Breaking Poster Session - Late-Breaking Research: Cellular and Molecular Biology 1: abstract no. LB-15INTRODUCTION: Endometrial cancer is the most common gynaecological cancer worldwide and its incidence in Asia is rising. It can be classified into two major types: the estrogen dependent type I endometrioid carcinoma that comprises about 80% of endometrial cancers and the type II non-endometroid carcinoma, which is ...link_to_OA_fulltextThe 102nd Annual Meeting of the American Association for Cancer Research (AACR 2011), Orlando, FL., 2-6 April 2011

A comparison of the acceptance of immunochemical faecal occult blood test and colonoscopy in colorectal cancer screening: A prospective study among Chinese

Background Preferences to choose immunochemical faecal occult blood test (FIT) and colonoscopy as colorectal cancer (CRC) screening modalities among asymptomatic Chinese subjects remain unknown. Aim To evaluate the preference of choosing colonoscopy vs. FIT among CRC screening participants. Methods From a community-based CRC screening programme for asymptomatic Hong Kong Chinese aged 50-70 years, participants attended standardized educational sessions and chose the options of annual FIT for 5 years or direct colonoscopy once. Factors associated with choosing colonoscopy were evaluated by multivariate regression analysis. Results Among 3430 participants [mean age 56.8 years (s.d. 5.0); female 55.1%, male 44.9%], 51.3% chose colonoscopy and 48.7% chose FIT. Older participants (65-70 years) were less likely to choose colonoscopy [adjusted odds ratio (aOR) 0.731, P = 0.041]. Subjects who chose colonoscopy were those disagreed screening would lead to discomfort (aOR 1.356, P < 0.001), had relatives or friends who had CRC (first degree relatives aOR 1.679, P < 0.001; second degree relatives aOR 1.304, P = 0.019; friends or others aOR 1.252, P = 0.026) and those who self-perceived their health as poor (aOR 1.529, P = 0.025). Conclusions Faecal occult blood test and direct colonoscopy were equally preferable to Chinese. Colonoscopy was preferred among the younger subjects, those with positive family history of CRC and self-perceived poor health status. © 2010 Blackwell Publishing Ltd.link_to_subscribed_fulltex

Techniques for the study of apoptosis in bone

Osteocyte apoptosis has been associated with a number of clinical conditions in bone and with the targeted turnover of specific skeletal areas. There has been great interest in the identification of the mechanisms by which apoptosis is regulated in bone and in the biological role that this process plays in bone metabolism and associated bone disease or loss of structural integrity. Here we describe several methods for the detection of apoptosis in bone sections and in bone cell cultures