A public health approach to hepatitis C control in low- and middle-income countries.

In light of new treatment regimens for hepatitis C, Amitabh Suthar and Anthony Harries outline a wider public health approach for tackling the disease

Design of Lean to Roof Steel Trusses with Hollow Circular tube using IS 875 (part-III):2015 & IS 800:2007

At present, SP-38:1987 is available which provides design for lean to roof type trusses and pitch roof trusses. The design of lean to roof truss has been carried out as per IS 800:1984 IS 875 (Part-III):1964. Afterwards IS 800:1984 is revised in 2007, which is based on limit state method. Also, IS 875 (Part-III) is updated in 1987 and then in 2015 considering climate changes and economical parameters. Accordingly, study has been done to revise the design of trusses given in SP-38:1987. In the present study, design and comparison of lean to roof type truss with steel circular hollow tube section have been carried out using IS 875 (Part-III):2015 and IS 800:2007 limit state method using STAAD Pro. and their results compared with SP-38:1987 results. This study includes lean to roof truss system considering different parameters like span, spacing of truss, slope of roof and wind zones with all cases of wind load. At the end, a compiled report will be prepared, which will be helpful to design engineers to provide economic, easier, faster approach for designing of steel trusses

Knowledge, attitudes and practices of medical researchers toward authorship in scientific journals

Background: The knowledge, attitudes and practices of scientific authorship vary across different regions. We conducted this study to understand this variation among medical researchers in India.Methods: An anonymous web-based researcher-survey invited all faculty, researchers and PhD students at Pacific institute of Medical sciences, Udaipur, India. The study design and the questionnaire were approved by the institutional ethics committee.  Basic information on study was given to obtain consent for participation. The 30 questions on authorship experience and related issues were based on the statements in International Committee of Medical Journal Editors (ICMJE) and other national and international recommendations on authorship. Participants reported their authorship experiences and answered multiple choice questionnaires.Results: The response rate was 36.36% among the participants, who were post-graduate with up to 10 years of research experience. About 62.5% had not been appropriately acknowledged as authors at some point during their career. Contributors (authorship) and ethical peer review is perceived as the key principle of research integrity. Though, single authorship was regarded as more significant, interdisciplinary management of diseases increases number of co-authors. A platform to challenge authorship, declaration of contribution in authorship and shared responsibility of co-authors in case of fraudulent publication was majority opinion.Conclusions: Almost 50 of the participant medical researchers had knowledge of formal authorship requirements. Majority agreed with the criteria would help in decreasing the authorship dispute in the medical research. There is need for awareness and continuous education on these criteria

Cruciate retaining versus posterior-stabilized total knee arthroplasty: a short-term comparative study

Background: Total knee arthroplasty has got excellent results. Among the techniques (posterior-stabilized vs posterior cruciate retaining total knee arthroplasty) it is unclear whether one design has superior outcome over another. The purpose of the present study was to directly compare clinical and radiological outcomes of these two designs.Methods: A prospective study involving 36 patients who received a cruciate-retaining implant were compared to 30 patients who received posterior-stabilized prosthesis. At 3 months follow-up time clinical and radiological evaluation done and results were analyzed.Results: At 3 months follow-up time mean knee society scores improved from 49.9/46.9 (objective/subjective score) points to 80.9/82.5 points in the cruciate-retaining group and from 48.2/43 (objective/subjective score) points to 80.4/80.2 points in the posterior-stabilized group. The ranges of motion was 117.2° (range, 90° to 130°) and 125.3° (range, 100° to 140°) in the cruciate-retaining and posterior-stabilized group respectively, at 3 month follow-up. One patient had post-operatively periprosthetic fracture reported after 2 weeks (treated conservatively), one had superficial infection (treated with dressing) and one patient with superfical infection required debridement.Conclusions: This study did not conclusively demonstrate the superiority of one knee design over the other, suggesting that the choice of implant should be based on surgeon preference, patients knee dimensions, pre-op knee deformity and existing pathology of the posterior cruciate ligament

Nanotechnology, a Revolutionary Technique in the Food Industry: Systematic Review

Nanotechnology has a great role in food industry in terms of processing, packaging, preservation and storage. Nanotechnology provides a wide variety of possibilities in food industry applications. Nanotechnology is now leading in the main field of food industry with the development of other technologies. Usage of nanoencapsulation technique to use the bioactive compound for successful delivery. In addition, nanoencapsulation enables the control of flavour release during processing and storage at the desired time and the prevention of flavour degradation. The use of nano biosensors in packaging technique that definitely detects harmful components in food, pathogen identification, changes in food characteristics and food quality. Nonetheless, there is no question that nanotechnology is making a significant contribution to the newly developed advanced technique but safety is also a major concern, when it comes to the use of this technique in food industry, growth and protection should be pushed in parallel to the overall progress of the food industry and consumers

Metabolic Perturbations Associated with both PFAS Exposure and Perinatal/Antenatal Depression in Pregnant Individuals: A Meet-in-the-Middle Scoping Review

Purpose of reviewDepression during the perinatal or antenatal period affects at least 1 in 10 women worldwide, with long term health implications for the mother and child. Concurrently, there is increasing evidence associating maternal exposure to per- and poly-fluoroalkyl substances (PFAS) to adverse pregnancy outcomes. We reviewed the body of evidence examining both the associations between PFAS exposure and perturbations in the maternal metabolome, and the associations between the maternal metabolome and perinatal/antenatal depression. Through this, we sought to explore existing evidence of the perinatal metabolome as a potential mediation pathway linking PFAS exposure and perinatal/antenatal depression.Recent findingsThere are few studies examining the metabolomics of PFAS exposure-specifically in pregnant women-and the metabolomics of perinatal/antenatal depression, let alone studies examining both simultaneously. Of the studies reviewed (N = 11), the majority were cross sectional, based outside of the US, and conducted on largely homogenous populations. Our review identified 23 metabolic pathways in the perinatal metabolome common to both PFAS exposure and perinatal/antenatal depression. Future studies may consider findings from our review to conduct literature-derived hypothesis testing focusing on fatty acid metabolism, alanine metabolism, glutamate metabolism, and tyrosine metabolism when exploring the biochemical mechanisms conferring the risk of perinatal/antenatal depression due to PFAS exposure. We recommend that researchers also utilize heterogenous populations, longitudinal study designs, and mediation approaches to elucidate key pathways linking PFAS exposures to perinatal/antenatal depression

Enhanced Distributed File Replication Protocol for Efficient File Sharing in Wireless Mobile Ad-Hoc Networks.

File sharing applications in mobile unintended networks (MANETs) have attracted additional and additional attention in recent years. The potency of file querying suffers from the distinctive properties of such networks as well as node quality and restricted communication vary and resource. associate degree intuitive methodology to alleviate this drawback is to form file replicas within the network. However, despite the efforts on file replication, no analysis has targeted on the worldwide optimum duplicate creation with minimum average querying delay. Specifically, current file replication protocols in mobile unintended networks have 2 shortcomings. First, they lack a rule to portion restricted resources to completely different files so as to reduce the typical querying delay. Second, they merely contemplate storage as offered resources for replicas, however neglect the actual fact that the file holders’ frequency of meeting different nodes additionally plays a crucial role in deciding file availableness. Actually, a node that contains a higher meeting frequency with others provides higher availableness to its files. This becomes even additional evident in sparsely distributed MANETs, during which nodes meet disruptively. during this paper, we have a tendency to introduce a replacement conception of resource for file replication, that considers each node storage and meeting frequency. we have a tendency to on paper study the influence of resource allocation on the typical querying delay and derive a resource allocation rule to reduce the typical querying delay. we have a tendency to additional propose a distributed file replication protocol to appreciate the projected rule. intensive trace-driven experiments with synthesized traces and real traces show that our protocol are able to do shorter average querying delay at a lower value than current replication protocols

A comparative study of clinical, biochemical and hematological profiles in smear positive malaria patients: at a tertiary care center located in rural part of Gujarat, India

Background: Aims and objectives of current study were to study the clinical, biochemical and hematological profiles in smear positive malaria patients and its correlation to immediate outcome of patient. To analyze the biochemical and hematological imbalances and its correlation with clinical presentation and type of malarial parasites. To elucidate the correlation of hematological and biochemical changes in children infected with malaria and their impact on immediate outcome of patients.Methods:All patients admitted with a diagnosis of malaria in department of Pediatrics at Dhiraj Hospital, Piparia, Vadodara, during the study period of January 2013 to June 2014. Sample size was 106 cases. Inclusion criteria for the study was all children under 18 years of age with smear positive malaria cases diagnosed. The study was done after obtaining a detailed history, complete general physical examination and systemic examination. The patients were subjected to relevant investigations. The data regarding patient particulars, diagnosis and investigations is collected in a specially designed case recording form and transferred to a master chart subjected to statistical methods like mean, standard deviation, proportion, percentage calculation and wherever necessary chi square test for proportion are used.Results: Total 106 patients were enrolled in study. Complications of PF (N=31): Jaundice 16%, severe anemia 23%, thrombocytopenia 29%, leukopenia in 23%, hyponatremia in 29.1%, cerebral malaria in 16% and hyperkalemia in 17%. Complications of PV (N=65): Jaundice 20%, severe anemia 20%, thrombocytopenia 18%, leukopenia in 11%, hyponatremia in 44.6%, hyperkalemia in 9%, cerebral malaria in 12.3%  and hypoglycemia in 3.77%.Conclusions:The incidence of malaria is higher in males than females. Thrombocytopenia is very common in malaria, but spontaneous bleeding is not so common finding in malaria. Mixed infections behave like falciparum malaria. P. vivax malaria though traditionally considered to be a benign entity can also have a severe and complicated course, which is usually associated with P. falciparum malaria.

Novel approaches to acoustic immunosensing of extracellular vesicles

Extracellular vesicles (EVs) constitute a promising source of biomarkers for disease diagnostics and can be obtained via liquid biopsies from various bodily fluids. While much progress has been made in recent years, challenges remain on the sensitivity, specificity and clinical implementation of current analytical workflows

Growth and Characterization of MnBi2Te4 Magnetic Topological Insulator

We report successful growth of magnetic topological insulator (MTI) MnBi(2)Te(4)singlecrystalby solid state reaction route via self flux method. The phase formation of MnBi(2)Te(4)singlecrystalis strongly dependent on the heat treatment. MnBi(2)Te(4)is grown in various phases i. e., MnBi4Te7, MnBi6Te10 and MnTe as seen in powder X-ray diffraction (PXRD) of crushed resultant crystal. The Rietveld analysis shows some impurity lines along with the main phase MnBi2Te4. Low temperature (10K) magneto-resistance (MR) in applied magnetic field of up to 6 Tesla exhibited - ve MR below 0.5 Tesla and +ve for higher fields. The studied MnBi2Te4, MTI crystal could be a possible candidate for Quantum Anomalous Hall (QAH) effect. Here we are reporting a newly discovered magnetic topological insulator MnBi(2)Te(4)having non-trivial symmetry as well as strong Spin-Orbit Coupling forQAH effect