3,263 research outputs found
Integrated Information System for Sustainable Urban Regeneration
Information systems are widely used in urban planning process for communication between different side actors. However, most of them have been implemented without providing possibilities for decision makers to participate together with urban planners in the process. This research aims to outline a framework where an interactive model for decision making plays a key role in creating a collaborative environment. The proposal regards the information representation as the main instrument for encouraging a constructive dialog between different actors. The focus is on the relationship between three elements of information representation: level of detail, type of visualization and interaction. Combining these elements, information can be provided in a dynamic way enabling more effective exploration and understanding. The proposed strategy implements a digital model that operates on different scales and levels in order to support the key stages of the planning process for sustainable urban regeneration in Bulgaria. Positional approach is used to define the functionality and decision making operation for the selected process. As a result research ideas about the use of the digital model are presented
Ru-Catalyzed, cis-Selective Living Ring-Opening Metathesis Polymerization of Various Monomers, Including a Dendronized Macromonomer, and Implications to Enhanced Shear Stability
An unsaturated polymer’s cis/trans-olefin content has a significant influence on its properties. For polymers obtained by ring-opening metathesis polymerization (ROMP), the cis/trans-olefin content can be tuned by using specific catalysts. However, cis-selective ROMP has suffered from narrow monomer scope and lack of control over the polymerization (giving polymers with broad molecular weight distributions and prohibiting the synthesis of block copolymers). Herein, we report the versatile cis-selective controlled living ROMP of various endo-tricyclo[4.2.2.0^(2,5)]deca-3,9-diene and various norbornene derivatives using a fast-initiating dithiolate-chelated Ru catalyst. Polymers with cis-olefin content as high as 99% could be obtained with high molecular weight (up to M_n of 105.1 kDa) and narrow dispersity (<1.4). The living nature of the polymerization was also exploited to prepare block copolymers with high cis-olefin content for the first time. Furthermore, owing to the successful control over the stereochemistry and narrow dispersity, we could compare cis- and trans-rich polynorbornene and found the former to have enhanced resistance to shear degradation
Functional analysis of the Sec62 C-terminal domain in membrane protein biogenesis
About 30 % of proteome in yeast are targeted to the endoplasmic reticulum (ER) membrane either by the signal recognition particle (SRP)-dependent pathway or the SRP-independent pathway. In the SRP-independent pathway, an essential protein Sec62p cooperates with Sec61p, a main protein conducting channel for the ER targeted membrane and secretory proteins. However, the molecular mechanism of Sec62p in this process has not been elucidated in detail. The cytosolic C-terminal domain of Sec62p has been proposed as an acceptor site for N-terminal signal sequences of secretory proteins. To further study the role of the C-terminus of Sec62p in membrane protein biogenesis, C-terminal mutants of Sec62p were prepared and the membrane insertion of model membrane proteins was examined. We found that P219A mutation reduced the C-terminal translocation of model membrane proteins, suggesting that the C-terminus of Sec62p may function on the insertion of membrane proteins into the ER membrane. In addition, we probe for the site of physical interaction between Sec62p and the substrate proteins using a site-specific cross-linking approach.OAIID:RECH_ACHV_DSTSH_NO:A201502713RECH_ACHV_FG:RR00200003ADJUST_YN:EMP_ID:A078040CITE_RATE:FILENAME:20151103_미국학회발표_1104_정성준_포스터.pdfDEPT_NM:생명과학부EMAIL:[email protected]_YN:FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/b4ee90b0-b90d-4c99-9f8b-6c02c30e11cd/linkCONFIRM:
Effect of Aroma Hand Massage on Anxiety and Immune Function in Patients with Gynecology Surgery under Local Anesthesia
PURPOSE: The purpose of this study was to examine the effects of aroma hand massage on anxiety and immune function in patients who had gynecology surgery under local anesthesia.
METHODS: The research design was a nonequivalent control group with pre- and posttest design. Data were collected from June 5 to October 6, 2010. Participants included 20 patients in the aroma hand massage group, 20 patients in a hand massage group, and 20 in a control group. As an experimental treatment, hand massage was carried out following the hand massage protocol. Measures consisted of the State Trait Anxiety, Numeric Rating Scale (NRS) for anxiety, vital signs (systolic and diastolic blood pressure, pulse rate), and salivary cortisol for anxiety, and immunoglobulin A for immune function.
RESULTS: Aroma hand massage and hand massage group showed lower levels in NRS for anxiety, systolic and diastolic blood pressure, and pulse rate (p&lt;.001) compared to controls. No group differences were found for state anxiety, salivary cortisol and immunoglobulin A.
CONCLUSION: The results indicate that aroma hand massage and hand massage are effective in reducing anxiety and can be complementary alternative interventions for women having gynecology surgery under local anesthesia
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