8 research outputs found
Tight junctions: from simple barriers to multifunctional molecular gates
Get PDFEpithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. Tight junctions also form the border between the apical and basolateral plasma-membrane domains and are linked to the machinery that controls apicobasal polarization. Additionally, signalling networks that guide diverse cell behaviours and functions are connected to tight junctions, transmitting information to and from the cytoskeleton, nucleus and different cell adhesion complexes. Recent advances have broadened our understanding of the molecular architecture and cellular functions of tight junctions
RNA interference mediated JAM-A gene silencing promotes human epidermal stem cell proliferation
No full textCloning and expression of a Chk1 gene in Daphnia pulex during different modes of reproduction
No full textNanoscale Imaging Reveals a Tetraspanin-CD9 Coordinated Elevation of Endothelial ICAM-1 Clusters
No full textmicroRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements
No full textTspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression
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