3,512 research outputs found
Identification of a novel nuclear export sequence of OREBP / TonEBP / NFAT5 that controls cytoplasmic localization
published_or_final_versio
Prevalence of hospital acquired enterococci infections in two primary-care hospitals in Osogbo, Southwestern Nigeria
Enterococci are opportunistic bacteria that become pathogenic when they colonize niches where they are not normally found. Of recent, they have become major cause of nosocomial infections, especially of the bloodstream, urinary tract and surgical sites. The aim of this study is to determine the point‐prevalence rate of human enterococci infections among hospitalized patients in Osogbo, Nigeria. The study was conducted between January and June 2009 in two primary‐care hospitals in Osogbo and involved a total of 118 patients who developed clinical evidence of infection at least 48 hours after hospital admission. Appropriate clinical samples were collected from the patients after an informed consent and cultured for isolation/biochemical identification of Enterococcus species at the Bacteriology Laboratory of Ladoke Akintola University of Technology, Osogbo using standard microbiological methods. There were 525 hospital admissions within the time frame of the study of which 118 (22.5%) developed hospital acquired infection (HAI); 58 (49.2%) of which cultured positive for bacterial pathogens. Enterococci were isolated from infective focus in 7 patients, giving a prevalence rate of hospital‐acquired enterococci infection of 5.9%. Two species of Enterococcus were identified; Enterococcus faecalis from urinary tract infection (UTI) and surgical site infection (SSI) of 6 (85.7%) patients and Enterococcus faecium from UTI in 1 (14.3%) patient. Other bacteria recovered from other infective foci were Klebsiella spp 31.0%, Pseudomonas spp 20.7%, Staphylococcus aureus 17.2%, Escherichia coli 12.1%, Staphylococcus epidermidis 3.4%, Streptococcus pneumoniae 1.7% and Serratia spp 1.7%. All the enterococci isolates were multiply antibiotic resistant, and 42.9% were vancomycin‐resistant enterococci (VRE) with the VRE strains showing resistance to wider range of antibiotics than the vancomycin‐sensitive strains. Other Gram‐positive and Gram negative bacterial isolates also demonstrated multiple resistance to all commonly available antibiotics in this community except E. coli and Pseudomonas spp which were relatively sensitive to ciprofloxacin and ceftazidime. This limited study demonstrated a high prevalence rate of multiple antibiotic resistant enterococci infections among hospitalized patients in this environment. There is need for systematic surveillance of hospitals for enterococci infections; prudent use and rational prescription of antibiotics and stringent measures to reduce the prevalence rate by health education on infection control measures such asisolation, cleaning, disinfection and sterilization.Keywords: Nosocomial, Prevalence, Enterococcus, Vancomycin‐Resistance, Primary Car
Effect of leaching on heavy metals concentration of soil in some dumpsites
Study on the effect of leaching on heavy metals concentration at dumpsites was conducted by analyzing samples of soil collected from different dumpsites located within Ikere and Ado Ekiti metropolis, South Western Nigeria. The samples were analyzed for concentrations of Cd, Co, Cr, Cu, Fe, Pb, Mn, Ni, Sn and Zn. Control soil samples were taken at 200 m away from the last sampling point on each dump site down the slope and were also analyzed for the presence of these heavy metals. The results of the analyses show a significant difference in the concentration of these metals from the centre of each dumpsite at interval of 10 – 70 m down the slope (p < 0.05). The dumpsites were found to contain significant amount of toxic heavy metals. Hence, phytoremediation processes were suggested.Key words: Leaching, heavy metals, soil, dumpsites
Factors influencing contraceptives use among grandmultipara in Ile-Ife, Nigeria
Objective: To determine modifiable factors that influence contraceptive usage among grandmutiparas in a South-Western Nigerian setting.Methodology: A prospective survey was done among antenatal attendees in OAUTHC from January toDecember 2006. Using interviewer administered semi-structured questionnaire data were collected from all grandmultiparous attendees on sociodemographic characteristics, contraceptive awareness and usage, contraceptive intentions and the role of men on contraceptives usage. Data were analysed with SPSS 11.0 and result presented in descriptive statistics.Results: The prevalence of grandmultiparity was 9.04% in the studied population, and their mean age was 36.73 + 4.7years: Eighty-one percent attended secondary school, and 65% were monogamous. Despite high level of awareness (51.6-100%) contraceptive usage was low (5.9 to 40.8%). About 90% agreed that family planning improve quality of family life. While 80% had no intention for further childbearing only 36% intended to use BTL. Sex preference was the only motivation for further childbearing in all (100%) of them.Conclusion: High literacy rate in this group did not impart positively in reducing the unmet need. Increased awareness on permanent contraception and the role of men need to be promoted. Health education that will break the negative strongholds of cultural factors has to be introduced gradually at the primary school levels.Keywords: Contraceptive usage, Grandmultiparity, Cultural factors
GP-SUM. Gaussian Processes Filtering of non-Gaussian Beliefs
This work studies the problem of stochastic dynamic filtering and state
propagation with complex beliefs. The main contribution is GP-SUM, a filtering
algorithm tailored to dynamic systems and observation models expressed as
Gaussian Processes (GP), and to states represented as a weighted sum of
Gaussians. The key attribute of GP-SUM is that it does not rely on
linearizations of the dynamic or observation models, or on unimodal Gaussian
approximations of the belief, hence enables tracking complex state
distributions. The algorithm can be seen as a combination of a sampling-based
filter with a probabilistic Bayes filter. On the one hand, GP-SUM operates by
sampling the state distribution and propagating each sample through the dynamic
system and observation models. On the other hand, it achieves effective
sampling and accurate probabilistic propagation by relying on the GP form of
the system, and the sum-of-Gaussian form of the belief. We show that GP-SUM
outperforms several GP-Bayes and Particle Filters on a standard benchmark. We
also demonstrate its use in a pushing task, predicting with experimental
accuracy the naturally occurring non-Gaussian distributions.Comment: WAFR 2018, 16 pages, 7 figure
Crystallization and preliminary X-ray crystallographic analysis of a yedU gene product from Escherichia coli
A yedU gene product with a molecular mass of 31 kDa is a hypothetical protein with no known function. The protein was purified and crystallized at 296 K. X-ray diffraction data have been collected to 2.3 Angstrom using synchrotron radiation. The crystals belong to the primitive orthorhombic system, with unit-cell parameters a = 50.56, b = 63.45, c = 168.02 Angstrom. The asymmetric unit contains two monomers of the protein, with a corresponding V-M of 2.25 Angstrom(3) Da(-1) and a solvent content of 44.84%.open2
Modulation Of 3-Hydroxy-3-Methylglutaryl-Coa Reductase By 15 Alpha-Fluorolanost-7-En-3 Beta-Ol. A Mechanism-Based Inhibitor Of Cholesterol Biosynthesis.
Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease
RATIONALE: Peripheral arterial disease (PAD) is a clinical manifestation of extracoronary atherosclerosis. Despite sharing the same risk factors, only 20% to 30% of patients with coronary artery disease (CAD) develop PAD. Decline in the number of bone marrow–derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis. Whether specific changes in PCs differentiate patients with both PAD and CAD from those with CAD alone is unknown.
OBJECTIVE: Determine whether differences exist in PCs counts of CAD patients with and without known PAD.
METHODS AND RESULTS: 1497 patients (mean age: 65 years; 62% men) with known CAD were identified in the Emory Cardiovascular Biobank. Presence of PAD (n=308) was determined by history, review of medical records, or imaging and was classified as carotid (53%), lower extremity (41%), upper extremity (3%), and aortic disease (33%). Circulating PCs were enumerated by flow cytometry. Patients with CAD and PAD had significantly lower PC counts compared with those with only CAD. In multivariable analysis, a 50% decrease in cluster of differentiation 34 (CD34+) or CD34+/vascular endothelial growth factor receptor-2 (VEGFR2+) counts was associated with a 31% (P=0.032) and 183% (P=0.002) increase in the odds of having PAD, respectively. CD34+ and CD34+/VEGFR2+ counts significantly improved risk prediction metrics for prevalent PAD. Low CD34+/VEGFR2+ counts were associated with a 1.40-fold (95% confidence interval, 1.03–1.91) and a 1.64-fold (95% confidence interval, 1.07–2.50) increases in the risk of mortality and PAD-related events, respectively.
CONCLUSIONS: PAD is associated with low CD34+ and CD34+/VEGFR2+ PC counts. Whether low PC counts are useful in screening for PAD needs to be investigated
Predictors of betel quid chewing behavior and cessation patterns in Taiwan aborigines
BACKGROUND: Betel quid, chewed by about 600 million people worldwide, is one of the most widely used addictive substances. Cessation factors in betel quid chewers are unknown. The present study explores prevalence and the quit rate of betel quid chewing in Taiwan aborigines. Our goal was to delineate potential predictors of chewing cessation. METHODS: A stratified random community-based survey was designed for the entire aborigines communities in Taiwan. A total of 7144 participants were included between June 2003 and May 2004 in this study. Information on sociodemographic characteristics, such as gender, age, obesity, education years, marital status, ethnicity, and habits of betel quid chewing, smoking and drinking was collected by trained interviewers. RESULTS: The prevalence of betel quid chewers was 46.1%. Betel quid chewing was closely associated with obesity (OR = 1.61; 95% CI: 1.40–1.85). Betel quid chewers were most likely to use alcohol and cigarettes together. Quit rate of betel quid chewers was 7.6%. Betel quid chewers who did not drink alcohol were more likely to quit (OR = 1.89; 95% CI: 1.43–2.50). Alcohol use is a significant factor related to cessation of betel quid chewing, but smoking is not. CONCLUSION: Taiwan aborigines have a high prevalence of betel quid chewers and a low quit rate. Alcohol use is strongly association with betel quid chewing. Efforts to reduce habitual alcohol consumption might be of benefit in cessation of betel quid chewing
Self-bound dense objects in holographic QCD
We study a self-bound dense object in the hard wall model. We consider a
spherically symmetric dense object which is characterized by its radial density
distribution and non-uniform but spherically symmetric chiral condensate. For
this we analytically solve the partial differential equations in the hard wall
model and read off the radial coordinate dependence of the density and chiral
condensate according to the AdS/CFT correspondence. We then attempt to describe
nucleon density profiles of a few nuclei within our framework and observe that
the confinement scale changes from a free nucleon to a nucleus. We briefly
discuss how to include the effect of higher dimensional operator into our
study. We finally comment on possible extensions of our work.Comment: 17 pages, 5 figures, figures replaced, minor revision, to appear in
JHE
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